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New light-activated Photochemical Tissue Bonding technology helps treat battlefield injuries

Airmen's traumatic battlefield injuries may be more effectively treated by using a new light-activated technology developed as a result of research managed by Air Force Office of Scientific Research and supported by funds from the Office of the Secretary of Defense.

4 May 2010

Johns Hopkins researchers identify a key protein that triggers sarcoidosis

Lung researchers at Johns Hopkins have identified a possible protein trigger responsible for sarcoidosis, a potentially fatal inflammatory disease marked by tiny clumps of inflammatory cells that each year leave deep, grainy scars on the lungs, lymph nodes, skin and almost all major organs in hundreds of thousands of Americans.

4 May 2010

Tart cherries reduce osteoarthritis pain

Arthritis affects about one-quarter of Americans and has been called "the coming epidemic" by the Centers for Disease Control and Prevention. More than 67 million adults are expected to be afflicted by 2030. May is National Arthritis Month and experts like registered dietitian Dave Grotto want Americans to take a food-first approach to managing arthritis pain.

4 May 2010

BioMarker Strategies receives $1M NCI grant funding to develop SnapPath live tumor cell testing system

BioMarker Strategies announced today that the National Cancer Institute (NCI) has approved the first $1 million in Phase II funding for the company's Small Business Innovative Research (SBIR) contract to develop the SnapPath™ live tumor cell testing system. The company is developing the SnapPath™ system to better enable drug companies to stratify patients in clinical trials, as well as assist oncologists in determining the most effective targeted drug treatment for their cancer patients.

4 May 2010

Neural stem cell transplantation promising for Batten disease

Neuronal Ceroid Liposfuscinosis (NCL), often referred to as Batten disease, is a rare and fatal neurodegenerative disorder that afflicts infants and young children. NCL is caused by a deficiency of a lysosomal enzyme, and is a relatively rare disease, affecting an estimated 2 to 4 of every 100,000 babies born in the U.S. Although NCLs are classified as rare diseases, they often affect more than one child in families that carry the defective gene, and tragically, are always fatal.

4 May 2010

Study reveals how human brain adapts to complex situations

Scientists have long known that the brain's frontal cortex supports concrete rule learning. Less clear is how the brain processes more complex and unfamiliar knowledge. In a paper published today (Wednesday, April 28, 2010) in the journal Neuron, a team of researchers at Brown University and the University of California-Berkeley tested whether the frontal lobe has the ability to process more abstract knowledge and how this ability could help navigate new situations and stimuli.

4 May 2010

Hormone-like inner ear signaling system protects against noise-induced hearing loss

An in vivo study shows for the first time that there is a stress-response system within the cochlea that mirrors the signaling pathways of the body's fight or flight response. Researchers have identified a hormone-like signaling system of the inner ear that sets baseline hearing sensitivity and helps protect against noise-induced hearing loss.

4 May 2010

JGH researchers identify 13 new genes associated with osteoporosis, bone weakness

A team of international researchers has identified 20 genes associated with osteoporosis and bone weakness, including 13 genes never previously associated with the disease. Osteoporosis is a highly heritable trait, but this marks the largest international effort to conclusively identify genes linked to the often-devastating bone disorder.

4 May 2010

Scientists introduce a new way of identifying key cancer genes

A new study shows that a family of molecules called microRNA work together in single, well-connected networks to control many important functions in healthy cells, but that in cancer cells the networks are rewired and fragmented.

4 May 2010

Broccoli component sulforaphane targets and kills breast cancer stem cells

A compound derived from broccoli could help prevent or treat breast cancer by targeting cancer stem cells -- the small number of cells that fuel a tumor's growth -- according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

4 May 2010

Researchers convert established human iPS cells, ES cells to base state of greater pluripotency

Whitehead Institute researchers have converted established human induced pluripotent stem cells and human embryonic stem cells to a base state of greater pluripotency.

4 May 2010

Stratatech to advance living human skin substitute tissue clinical trial with $3M funding round

Stratatech Corp., a regenerative medicine company focused on the commercialization of cell-based, tissue-engineered skin substitute products, today announced that it has closed a $3.0-million round of funding comprised of convertible notes. The funding was secured from current investors in the company. The proceeds will be used to advance the clinical trial of the company's StrataGraft® living human skin substitute tissue. The company expects to begin Phase IIb of the trial during the second half of 2010.

4 May 2010

Researchers receive $250,000 to study inventive cell-transfer therapy to treat cortical dysplasia

University of Florida researchers will receive $250,000 to study an inventive cell-transfer therapy to treat cortical dysplasia, a condition where the brain develops abnormally before birth, causing severe epilepsy in children and adults.

4 May 2010

Boost for biologics manufacturing in Australia

AusBiotech has welcomed the news that Australia’s first major contract manufacturing facility for biologic medicines has secured backing and is set to be built in Queensland by 2012.

3 May 2010

Researchers identify genes associated with cleft lip and/or cleft palate

An international consortium of scientists, led by researchers at Johns Hopkins University has identified two genes that when altered are closely associated with cleft lip and/or cleft palate. Cleft lip and cleft palate are among the world's most common congenital malformations and occur in one in every 700 births. The finding is the result of the largest family-based, genome-wide study of cleft lip and/or cleft palate conducted to date. The results were published online by the journal Nature Genetics.

3 May 2010

FDA issues advisory on prostate cancer drugs

Gonadotropin-Releasing Hormone (GnRH) agonists, a class of medications primarily used to treat men with prostate cancer, have been associated with a small increased risk for diabetes, heart attack, stroke, and sudden death in men treated with one of the medications, according to a preliminary and ongoing analysis of several studies by the U.S. Food and Drug Administration.

3 May 2010

NOXXON Pharma completes first-in-human clinical trial with Spiegelmer NOX-A12

NOXXON Pharma AG, the biopharmaceutical company focusing on the development of novel drugs based on its unique proprietary Spiegelmer® technology, announced today the successful completion of the first-in-human clinical trial with Spiegelmer® NOX-A12.

3 May 2010

HTG, JWCI collaborate to develop new approaches for early stage primary cutaneous melanoma diagnosis

HTG, Inc., provider of the quantitative Nuclease Protection Assay (qNPA™), today announced it signed a collaboration agreement with the John Wayne Cancer Institute (JWCI) at Saint John's Health Center in Santa Monica, California. Under the terms of the agreement, HTG and JWCI (Department of Molecular Oncology, Dave S. B. Hoon, Ph.D., Director) will collaborate to generate a novel mRNA signature that can measure the gene expression differences in melanoma and benign nevi using HTG's qNPA technology in classical surgical pathology samples.

3 May 2010

Interim study results demonstrate anti-tumor activity of CytRx's INNO-206 in myeloma tumor cells

CytRx Corporation, a biopharmaceutical company specializing in oncology, today announced interim study results that showed its doxorubicin prodrug INNO-206 demonstrated statistically significant anti-tumor activity in human myeloma tumor cells growing in immune-deficient mice compared to a control group, while exhibiting significantly less toxicity than doxorubicin even though INNO-206 was administered at much higher doses.

3 May 2010

Curis completes enrollment in Phase I clinical trial of CUDC-101 HDAC, EGFR and HER2 inhibitor

Curis, Inc., a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that it has successfully completed enrollment and treatment of the last patient in its Phase I clinical trial of CUDC-101, Curis' first-in-class HDAC, EGFR and HER2 inhibitor.

3 May 2010

Medical Science News

New light-activated Photochemical Tissue Bonding technology helps treat battlefield injuries

Johns Hopkins researchers identify a key protein that triggers sarcoidosis

Tart cherries reduce osteoarthritis pain

BioMarker Strategies receives $1M NCI grant funding to develop SnapPath live tumor cell testing system

Neural stem cell transplantation promising for Batten disease

Study reveals how human brain adapts to complex situations

Hormone-like inner ear signaling system protects against noise-induced hearing loss

JGH researchers identify 13 new genes associated with osteoporosis, bone weakness

Scientists introduce a new way of identifying key cancer genes

Broccoli component sulforaphane targets and kills breast cancer stem cells

Researchers convert established human iPS cells, ES cells to base state of greater pluripotency

Stratatech to advance living human skin substitute tissue clinical trial with $3M funding round

Researchers receive $250,000 to study inventive cell-transfer therapy to treat cortical dysplasia

Boost for biologics manufacturing in Australia

Researchers identify genes associated with cleft lip and/or cleft palate

FDA issues advisory on prostate cancer drugs

NOXXON Pharma completes first-in-human clinical trial with Spiegelmer NOX-A12

HTG, JWCI collaborate to develop new approaches for early stage primary cutaneous melanoma diagnosis

Interim study results demonstrate anti-tumor activity of CytRx's INNO-206 in myeloma tumor cells

Curis completes enrollment in Phase I clinical trial of CUDC-101 HDAC, EGFR and HER2 inhibitor

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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