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Therapeutic cell types obtained from iPS cells demonstrate abnormal expansion and early cellular aging

Advanced Cell Technology, Inc. or “ACT” reported that a range of therapeutic cell types obtained from induced pluripotent stem (iPS) cells exhibit abnormal expansion and early cellular aging. The research, which appears online (published-ahead-of- print) in the journal STEM CELLS by ACT and its collaborators at Stem International (SCRMI), Harvard Medical School, and the University of Illinois, compares a variety of replacement cell types derived from human iPS cells with their embryonic stem (ES) cell counterparts. The findings support the use of ACT’s single blastomere-derived human embryonic stem cell lines which do not display early aging.

12 Feb 2010

Study could lead to new ways to combat obesity

The tiny tongue of a fruit fly could provide big answers to questions about human eating habits, possibly even leading to new ways to treat obesity, according to a study from a team of Texas A&M University researchers.

12 Feb 2010

Researchers discover cancer gene in ancestral metazoan

To find the causes for cancer, biochemists and developmental biologists at the University of Innsbruck, Austria, retraced the function of an important human cancer gene 600 million years back in time. For the first time, they have identified the oncogene myc in a fresh water polyp and they have shown that this oncogene has similar biochemical functions in ancestral metazoan and in humans.

12 Feb 2010

New amplitude gating technique helps scanners pinpoint tumors

When one diagnoses a cancer patient, it's important to gather as much information about that person as possible. But who would have thought an accurate diagnosis would depend on throwing some of that information away?

12 Feb 2010

Scientists uncover new gene that could help save sight of patients with inherited blindness

The international research team led by the University of Leeds found that the TSPAN12 gene is faulty in patients with a disease known as FEVR (Familial Exudative Vitreoretinopathy), which affects the development of the eye.

12 Feb 2010

First FDA-approved umbilical cord blood stem cells infusion trial in children with cerebral palsy

Medical College of Georgia researchers are conducting the first FDA-approved clinical trial to determine whether an infusion of stem cells from umbilical cord blood can improve the quality of life for children with cerebral palsy.

12 Feb 2010

British rhubarb could be a potential source of anti-cancer agent

Eating rhubarb baked in a crumble is not only tasty it may also be the best way to take advantage of its health benefits, and could lead to the development of new cancer treatments.

From Sheffield Hallam University 11 Feb 2010

Critical phases of brain development may be mistimed in autistic patients, says study

Research into Fragile X Syndrome - a genetic condition that is the leading known cause of autism - has discovered that critical phases in the brain's development may be mistimed in people with the condition.

11 Feb 2010

Chemical compound found in blood shows promise in preventing intractable form of heart failure

A chemical compound found normally in the blood has shown promise in treating and preventing an intractable form of heart failure in a mouse model of the disease, report researchers at the University of Illinois at Chicago College of Medicine.

11 Feb 2010

YM Biosciences to present JAK1/2 inhibiting small molecule and vascular disrupting agent data at Cancer Conference

YM BioSciences Inc., is presenting posters on its JAK1/2 inhibiting small molecule (CYT387) and on its novel vascular disrupting agent (CYT997) at the Lorne Cancer Conference in Lorne, Victoria, Australia. CYT387 is an oral JAK1/2 inhibitor, originating from the seminal discovery of JAK1 and JAK2 kinases by Dr. Andrew Wilks, the founder of Cytopia Limited, now YM Australia. CYT997 is an orally-available agent with dual mechanisms of vascular disruption and cytotoxicity and has the potential to be broadly active against a range of tumor types.

11 Feb 2010

PAREXEL International, Proteome Sciences form biomarker alliance

PAREXEL International Corporation, a leading global biopharmaceutical services provider, and Proteome Sciences plc, a leading provider of protein biomarker discovery, validation, and assay development services, today announced the formation of an alliance focused on enhancing PAREXEL's biomarker capabilities for early phase clinical development. PAREXEL is using Proteome Sciences' PS Biomarker Services™ protein and peptide biomarker capabilities to support biopharmaceutical companies in making earlier assessments of new compounds in development.

From Parexel 11 Feb 2010

Neurotoxin study may help find new therapies to block hyperactive ion channels

There are approximately 500 species of cone snails, each producing 50 - 200 different conotoxins. A similar number of peptide toxins are produced by snakes, spiders, sea anemones, scorpions and other venomous animals. The animals use the neurotoxins to paralyze their prey.

11 Feb 2010

hESC and iPSC: Long-term stem cell evaluation and comparison study

For the first time, scientists have performed a detailed long-term evaluation and comparison of two different types of pluripotent stem cells: human embryonic stem cells (hESC) and induced pluripotency stem cells (iPSC). Both cell types are believed to share equal characteristics, abilities and potential to differentiate into nearly 220 different cell types. However, hESC are isolated from early human embryos and iPSC are derived from reprogrammed adult somatic cells which makes them less controversial.

11 Feb 2010

New genetic 'hotspots' may help doctors devise therapies for bowel cancer patients

Cancer Research UK scientists have identified the frequency of new genetic 'hotspots' which could help doctors to tailor therapies to as many as 3,000 additional bowel cancer patients each year, according to research published in the British Journal of Cancer today.

11 Feb 2010

Oncogene has similar biochemical functions in ancestral metazoan and in humans

11 Feb 2010

Silver nanoparticles in higher-power, longer-life batteries for ICDs

Diamonds and gold may make some hearts flutter on Valentine's Day, but in a University at Buffalo laboratory, silver nanoparticles are being designed to do just the opposite.

11 Feb 2010

Therapeutic cell types obtained from iPS cells exhibit abnormal expansion and early cellular aging

Advanced Cell Technology, Inc. reported that a range of therapeutic cell types obtained from induced pluripotent stem (iPS) cells exhibit abnormal expansion and early cellular aging.

11 Feb 2010

Findings could lead to new targeted therapies for speech and learning disabilities

A team of University of Oregon researchers have isolated an independent processing channel of synapses inside the brain's auditory cortex that deals specifically with shutting off sound processing at appropriate times.

11 Feb 2010

Ingrid Grummt to receive 2010 FEBS/EMBO Women in Science Award

The European Molecular Biology Organization (EMBO) and the Federation of European Biochemical Societies (FEBS) announced Ingrid Grummt from the German Cancer Research Center in Heidelberg, Germany, as the winner of the 2010 FEBS/EMBO Women in Science Award. Ingrid Grummt has made important contributions to the field of transcriptional regulation in cells throughout her career.

11 Feb 2010

Neurology researchers explore link between MS and chronic cerebrospinal venous insufficiency

More than 55 percent of multiple sclerosis patients participating in the initial phase of the first randomized clinical study to determine if persons with MS exhibit narrowing of the extracranial veins, causing restriction of normal outflow of blood from the brain, were found to have the abnormality.

11 Feb 2010

Medical Science News

Therapeutic cell types obtained from iPS cells demonstrate abnormal expansion and early cellular aging

Study could lead to new ways to combat obesity

Researchers discover cancer gene in ancestral metazoan

New amplitude gating technique helps scanners pinpoint tumors

Scientists uncover new gene that could help save sight of patients with inherited blindness

First FDA-approved umbilical cord blood stem cells infusion trial in children with cerebral palsy

British rhubarb could be a potential source of anti-cancer agent

Critical phases of brain development may be mistimed in autistic patients, says study

Chemical compound found in blood shows promise in preventing intractable form of heart failure

YM Biosciences to present JAK1/2 inhibiting small molecule and vascular disrupting agent data at Cancer Conference

PAREXEL International, Proteome Sciences form biomarker alliance

Neurotoxin study may help find new therapies to block hyperactive ion channels

hESC and iPSC: Long-term stem cell evaluation and comparison study

New genetic 'hotspots' may help doctors devise therapies for bowel cancer patients

Oncogene has similar biochemical functions in ancestral metazoan and in humans

Silver nanoparticles in higher-power, longer-life batteries for ICDs

Therapeutic cell types obtained from iPS cells exhibit abnormal expansion and early cellular aging

Findings could lead to new targeted therapies for speech and learning disabilities

Ingrid Grummt to receive 2010 FEBS/EMBO Women in Science Award

Neurology researchers explore link between MS and chronic cerebrospinal venous insufficiency

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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