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RUNX1C isoform identified as driver of chemoresistance in acute myeloid leukemia

One of the biggest challenges in cancer treatment is that certain cancers reappear after chemotherapy-and an aggressive type of blood cancer called acute myeloid leukemia (AML) is notorious for this.

17 Aug 2025

Gut neurons drive immune responses through adrenomedullin 2

Neurons in the gut produce a molecule that plays a pivotal role in shaping the gut's immune response during and after inflammation, according to a new study by Weill Cornell Medicine investigators.

17 Aug 2025

Nanobody breakthrough offers precise targeting of lung cancer cells

A research team led by Dr. Juyeon Jung at the Bio-Nano Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), has developed a nanobody-based technology that can precisely identify and attack only lung cancer cells, opening new possibilities for cancer therapy.

17 Aug 2025

Plasma proteomics study unlocks predictive biomarkers for TNBC immunotherapy

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies, making immunotherapy a promising yet unpredictable option.

17 Aug 2025

New insights into how multisensory integration happens in the brain

It has long been understood that experiencing two senses simultaneously, like seeing and hearing, can lead to improved responses relative to those seen when only one sensory input is experienced by itself.

17 Aug 2025

Alzheimer’s gene risks differ by ancestry, major study reveals 133 new variants

Researchers used whole-genome sequencing from diverse populations to identify 156 variants, including 133 novel ones, linked to Alzheimer’s disease and related dementias. The study highlights ancestry-specific genetic risk and protective factors, challenging one-size-fits-all approaches to dementia genetics.

17 Aug 2025

Study shows probiotics help preterm babies fight antibiotic-resistant bacteria

Researchers found that probiotics help reduce antibiotic-resistant bacteria in the guts of very-low-birth-weight preterm infants, but cannot fully prevent resistance genes from spreading. Antibiotic use still promotes gene swapping, highlighting the limits of probiotics alone in neonatal care.

17 Aug 2025

Genetically-engineered immune cells show promise for preventing organ rejection

A Medical University of South Carolina team reports in Frontiers in Immunology that it has engineered a new type of genetically modified immune cell that can precisely target and neutralize antibody-producing cells complicit in organ rejection.

17 Aug 2025

Respiratory viruses awaken dormant breast cancer cells and raise relapse risk

Respiratory viruses such as influenza and COVID-19 can reactivate dormant breast cancer cells in the lungs, raising the risk of metastasis. The process is driven by IL-6–induced cell changes and immune suppression, with the highest recurrence risk soon after infection.

14 Aug 2025

Eating over 60g of almonds a day may protect DNA and cut oxidative damage

A meta-analysis of eight clinical trials found that almond supplementation, especially at doses above 60 g/day, significantly reduced oxidative DNA and lipid damage and improved antioxidant enzyme activity in adults. The benefits varied by biomarker and were influenced by dose, preparation, and participant characteristics.

14 Aug 2025

How moving to a walkable city can add 1,100 steps to your day

Moving to a more walkable city boosts daily step counts by around 1,100, with gains lasting at least three months and consistent across most demographic groups. Large walkability improvements nearly double the share of people meeting U.S. aerobic activity guidelines.

14 Aug 2025

GIPR signaling opens brain’s gate for GLP-1 weight-loss therapy

A Cell Metabolism study reveals that GIPR signaling in oligodendrocytes enhances brain access and weight-loss efficacy of GLP-1R agonists by increasing vascular permeability and targeting appetite-regulating neurons. This mechanism may explain why GIPR/GLP-1R co-agonists outperform single-agent therapies.

14 Aug 2025

Study finds vegetarians less likely to develop several common and rare cancers

A large North American cohort study found that vegetarian diets were linked to lower risks of several cancers, including colorectal, stomach, breast, prostate, and lymphoproliferative cancers. No evidence suggested that vegetarian eating increased cancer risk for any site.

14 Aug 2025

AI voice test could help spot dangerous throat lesions before symptoms appear

Researchers at Oregon Health and Science University found that variability in the harmonic-to-noise ratio (HNR) of speech could help distinguish benign from malignant vocal fold lesions, offering a potential early detection biomarker. The exploratory study used AI to analyze acoustic features from the Bridge2AI-Voice dataset and found differences most pronounced in male participants.

14 Aug 2025

Leg movement variability provides reliable marker of dystonia in pediatric cerebral palsy

Cerebral palsy affects around one in 345 children in the U.S., and more than half of them experience a problem called dystonia - involuntary and often painful muscle contractions, most commonly in the legs, that lead to abnormal movement and postures and make regular activities such as walking difficult.

14 Aug 2025

Cervicovaginal microbiome features predict severe chlamydia infection

A new study has identified markers that may predict whether a chlamydia infection is likely to ascend into the uterus and endometrium.

14 Aug 2025

High-speed 3D imaging microscope captures whole organism dynamics in real time

Researchers have developed a high-speed 3D imaging microscope that can capture detailed cell dynamics of an entire small whole organism at once.

14 Aug 2025

New model links striosomal activity to impaired decision making in psychiatric disorders

Scientists from the Icahn School of Medicine at Mount Sinai, working in collaboration with a team from the University of Texas at El Paso, have developed a novel computational framework for understanding how a region of the brain known as the striatum is involved in the everyday decisions we make and, importantly, how it might factor into impaired decision-making by individuals with psychiatric disorders like post-traumatic stress disorder and substance use disorder.

14 Aug 2025

Sex and residual enzyme activity primarily determine clinical course in Chinese Fabry patients

Fabry disease in mainland China is now mapped through the largest single-centre cohort to date, clarifying how α-galactosidase A deficiency, genotype and sex jointly sculpt the clinical spectrum.

14 Aug 2025

Systems biology identifies sentinel biomarkers bridging ankylosing spondylitis and myocardial infarction

Ankylosing spondylitis (AS) is increasingly recognized as an independent risk factor for premature myocardial infarction (MI), yet the molecular bridge linking chronic axial inflammation to acute coronary events remains poorly mapped.

14 Aug 2025