Molecular & Structural Biology

RSS

Autistic men have greater excitability in social brain regions than women, study reveals

New insight on differences in the brains of men and women with autism has been published today in the open-access journal eLife.

4 Aug 2020

Researchers develop scalable strategy to find novel molecular glue degraders

Despite enormous efforts to advance traditional pharmacology approaches, more than three quarters of all human proteins remain beyond the reach of therapeutic development.

4 Aug 2020

New method reveals the dynamics of cell development and gene activity

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only rather than time-lapse films.

4 Aug 2020

High-speed atomic force microscopy reveals diverse amyloid structures and dynamics

In the human body, proteins sometimes occur in fibrillar aggregates called amyloids. Although certain amyloids are known to have a biological function, amyloid formation is often associated with pathologies, including Alzheimer's and Parkinson's diseases.

3 Aug 2020

Study: ANGEL2 enzyme performs unique chemical reaction at the end of RNA molecules

Scientists led by Javier Martinez from the Max Perutz Labs, a joint venture of the Medical University of Vienna and the University of Vienna, have identified a unique chemical reaction at the end of RNA molecules for the first time in human cells.

31 Jul 2020

Deep learning algorithm can identify genetic alterations from routine histological images of tumors

Researchers at the University of Chicago Medicine Comprehensive Cancer Center, working with colleagues in Europe, created a deep learning algorithm that can infer molecular alterations directly from routine histology images across multiple common tumor types.

28 Jul 2020

Identification of MTK1 SAPKKK as new human oxidative stress sensor

In an aging society, various studies are being conducted to explore the relationship between active oxygen and aging-related diseases such as cancer, chronic inflammatory diseases, and metabolic syndrome.

28 Jul 2020

UMass Amherst biologists identify environmental sensing mechanism in cells

Evolutionary and developmental biologist Craig Albertson and colleagues at the University of Massachusetts Amherst report that they have identified a molecular mechanism that allows an organism to change the way it looks depending on the environment it is exposed to, a process known as phenotypic plasticity.

28 Jul 2020

Researchers identify a miRNA that could promote hair regeneration

Researchers from North Carolina State University have identified a microRNA (miRNA) that could promote hair regeneration.

27 Jul 2020

EBV viral genome alters the host epigenetic landscape to drive stomach cancer

The Epstein-Barr virus (EBV), one of the most common human viruses, is associated with about 8-10 per cent of stomach -- or gastric -- cancers, the third leading cause of cancer death globally.

27 Jul 2020

Study provides insight into evolution of amyloid-β oligomer with temporary salt crystals

Alzheimer's disease is the leading cause of dementia worldwide and a major cause of disability. Now, researchers at Osaka University and Hokkaido University have shown that repeated precipitation-dissolution events of salt crystals do occur even at low salt concentrations in nanoscales, and that it can accelerate the aggregation of the neurotoxic amyloid-β peptides implicated in its pathogenesis.

27 Jul 2020

Continuous survival of neurons is intrinsically programmed during development

When our neurons -- the principle cells of the brain -- die, so do we.Most neurons are created during embryonic development and have no "backup" after birth. Researchers have generally believed that their survival is determined nearly extrinsically, or by outside forces, such as the tissues and cells that neurons supply with nerve cells.

25 Jul 2020

Researchers use new approach to unravel the mechanisms that lie behind tetraploidy

Cell division is a fundamental process that organisms need to reproduce, grow, and make repairs. But when an error disrupts this complex biological process, cellular abnormalities can lead to diseases, such as cancer, where cells are enabled to grow and divide out of control.

25 Jul 2020

Study identifies mechanisms that underlie olfactory symptoms of COVID-19

A new study of human olfactory cells has revealed that viral invasion of supportive cells in the nasal cavity might be driving the loss of smell seen in some patients with COVID-19.

25 Jul 2020

Epigenomic modifications play key role in the development of lung tumors

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

23 Jul 2020

People who carry the Neandertal variant of ion channel experience more pain

As several Neandertal genomes of high quality are now available researchers can identify genetic changes that were present in many or all Neandertals, investigate their physiological effects and look into their consequences when they occur in people today.

23 Jul 2020

Engineered SARS-CoV-2 spike protein is more stable and can generate larger yields in the lab

A team of scientists has engineered the spike protein of the SARS-CoV-2 virus - a critical component of potential COVID-19 vaccines - to be more environmentally stable and generate larger yields in the lab.

23 Jul 2020

Study shows how mast cells regulate calcium levels to control the immune response

Instead of protecting us, the immune system can sometimes go awry, as in the case of autoimmune diseases and allergies. An Ludwig-Maximilian-Universitaet (LMU) in Munich team has dissected how mast cells regulate their calcium levels to keep the immune response under control.

23 Jul 2020

Analytik Jena Web Weeks – Analytik Jena launches new web seminar series for biomolecular applications, lab automation, and liquid handling

Analytik Jena is launching its brand new, English-language web seminar series “Analytik Jena Web Weeks” starting July 29, 2020. Until the end of the year, application specialists and product experts from Analytik Jena will present methods, technology solutions, and tips and tricks to make everyday laboratory work more efficient. Topics range from nucleic acid extraction, PCR, qPCR to liquid handling and laboratory automation.

From Analytik Jena US 23 Jul 2020

Calcium channel subunits play a crucial role in neurological disorders

The ability of the human brain to process and store information is determined to a large extent by the connectivity between nerve cells.

22 Jul 2020

Molecular & Structural Biology

Autistic men have greater excitability in social brain regions than women, study reveals

Researchers develop scalable strategy to find novel molecular glue degraders

New method reveals the dynamics of cell development and gene activity

High-speed atomic force microscopy reveals diverse amyloid structures and dynamics

Study: ANGEL2 enzyme performs unique chemical reaction at the end of RNA molecules

Deep learning algorithm can identify genetic alterations from routine histological images of tumors

Identification of MTK1 SAPKKK as new human oxidative stress sensor

UMass Amherst biologists identify environmental sensing mechanism in cells

Researchers identify a miRNA that could promote hair regeneration

EBV viral genome alters the host epigenetic landscape to drive stomach cancer

Study provides insight into evolution of amyloid-β oligomer with temporary salt crystals

Continuous survival of neurons is intrinsically programmed during development

Researchers use new approach to unravel the mechanisms that lie behind tetraploidy

Study identifies mechanisms that underlie olfactory symptoms of COVID-19

Epigenomic modifications play key role in the development of lung tumors

People who carry the Neandertal variant of ion channel experience more pain

Engineered SARS-CoV-2 spike protein is more stable and can generate larger yields in the lab

Study shows how mast cells regulate calcium levels to control the immune response

Analytik Jena Web Weeks – Analytik Jena launches new web seminar series for biomolecular applications, lab automation, and liquid handling

Calcium channel subunits play a crucial role in neurological disorders

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Latest Life Science News