Molecular & Structural Biology

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A gene regulatory multi-tool plays key role in unjamming the genome after DNA damage

A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA.

5 Apr 2019

Researchers determine atomic structure of fusion protein of a prokaryotic organism

Many viruses, including that perennial winter affliction, the influenza virus, are protected by a lipid membrane on loan from the host cell.

5 Apr 2019

Scientists use a promiscuous inhibitor to uncover cancer drug targets

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.

5 Apr 2019

New class of molecules could someday become basis for Zika-specific therapeutic

The Zika virus is widely known for causing microcephaly and other brain defects in the fetuses of pregnant, infected women.

4 Apr 2019

Researchers unravel 3D structure of key molecular target for cancer treatment

Columbia University scientists, in collaboration with researchers from Nimbus Therapeutics, have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment.

4 Apr 2019

Gut microbiome signatures in colorectal cancer transcend culture and diet

Patients with colorectal cancer have the same consistent changes in the gut bacteria across continents, cultures, and diets -- a team of international researchers, from University of Copenhagen among others, find in a new study.

4 Apr 2019

Study evaluates effects of unpaired 1 gene overexpression on lifespan in flies

Alexey Moskalev, Ph.D., Head of the Laboratory of Geroprotective and Radioprotective technologies, and co-authors from the Institute of biology of Komi Science Center of RAS announce the publication of a scientific article titled "Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster" in BMC Systems Biology - an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level.

4 Apr 2019

Analysis of tumor microenvironment to improve effectiveness of preclinical trials

It was shown that co-culturing HeLa adenocarcinoma cells, peripheral blood mononuclear cells, and mesenchymal stromal cells results in changes in the proliferative activity of the peripheral blood mononuclear cells and mesenchymal stromal cell populations.

3 Apr 2019

Molecular biologists develop pipeline to create and screen new lantibiotic peptides

Nature has provided us with lots of antimicrobials. However, given the rapid increase of antimicrobial resistance, there is a need for the development of new-to-nature antibiotics. Lantibiotics are an interesting option.

3 Apr 2019

Study finds cellular protein as a 'gas pump attendant' of cancer development

The cells which make up our body vary significantly. A liver cell does not look like a muscle cell and each has a unique function. This is because liver cells produce the proteins that characterize them, and muscle cells do the same.

1 Apr 2019

Scientists have more evidence of why clear margins in breast cancer surgery are such good news

When a breast cancer tumor is removed with no signs of cancer left behind, it's great news for patients, and now scientists have more evidence of why.

1 Apr 2019

Researchers discover natural gene therapy for intractable skin disease

Pathogenic gene mutations causing a type of intractable skin disease can be eliminated from some parts of patients' skin as they age, according to Hokkaido University researchers and their collaborators in Japan. This represents a form of natural gene therapy.

1 Apr 2019

Study provides better understanding of how cilia work and what causes oscillations

Human bodies have some built-in systems to care for themselves. The cells that line our lungs, nose, brain and reproductive system have cilia, which are tiny, hair-like structures designed to sweep out fluids, cells and microbes to stay healthy.

30 Mar 2019

Seemingly identical bacteria may have a different effect

Our gut microbiome - the complement of bacteria we carry around in our intestines - has been linked to everything from obesity and diabetes to heart disease and even neurological disorders and cancer.

30 Mar 2019

Pediatric Cell Atlas needed for better understanding of children’s health and illnesses

Research efforts to comprehensively map adult human cells are in progress. But in a Perspective publishing March 28 in the journal Developmental Cell, researchers argue that there is a need to map children’s cells with the same level of granularity.

29 Mar 2019

Single lineage of stem cells contributes to lifelong hippocampal neurogenesis in mice

Scientists once thought that mammals entered adulthood with all of the neurons they would ever have, but studies from the 60s found that new neurons are generated in certain parts of the adult brain and pioneering studies from the 90s helped identify their origins and function.

29 Mar 2019

Researchers discover how mosquitoes smell acidic volatiles in human sweat

Female mosquitoes are known to rely on an array of sensory information to find people to bite, picking up on carbon dioxide, body odor, heat, moisture, and visual cues.

29 Mar 2019

Lab-grown blood vessels provide hope for dialysis patients

Research published this week describes how lab-grown blood vessels were transformed into living tissue when grafted into dialysis patients needing replacement blood vessels.

28 Mar 2019

UTM researchers uncover 'master pacemaker' for biological clocks

What makes a biological clock tick? According to a new study from U of T Mississauga, the surprising answer lies with a gene typically associated with stem and cancer cells.

28 Mar 2019

Maternal age affects how well offspring respond to aging interventions, study shows

Advanced maternal age at the time of giving birth is known to decrease how long the offspring will live and their fecundity. However, why this occurs is unknown, and it remains unclear if maternal age also alters how offspring respond to interventions to aging.

28 Mar 2019

Molecular & Structural Biology

A gene regulatory multi-tool plays key role in unjamming the genome after DNA damage

Researchers determine atomic structure of fusion protein of a prokaryotic organism

Scientists use a promiscuous inhibitor to uncover cancer drug targets

New class of molecules could someday become basis for Zika-specific therapeutic

Researchers unravel 3D structure of key molecular target for cancer treatment

Gut microbiome signatures in colorectal cancer transcend culture and diet

Study evaluates effects of unpaired 1 gene overexpression on lifespan in flies

Analysis of tumor microenvironment to improve effectiveness of preclinical trials

Molecular biologists develop pipeline to create and screen new lantibiotic peptides

Study finds cellular protein as a 'gas pump attendant' of cancer development

Scientists have more evidence of why clear margins in breast cancer surgery are such good news

Researchers discover natural gene therapy for intractable skin disease

Study provides better understanding of how cilia work and what causes oscillations

Seemingly identical bacteria may have a different effect

Pediatric Cell Atlas needed for better understanding of children’s health and illnesses

Single lineage of stem cells contributes to lifelong hippocampal neurogenesis in mice

Researchers discover how mosquitoes smell acidic volatiles in human sweat

Lab-grown blood vessels provide hope for dialysis patients

UTM researchers uncover 'master pacemaker' for biological clocks

Maternal age affects how well offspring respond to aging interventions, study shows

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