Molecular & Structural Biology

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A family of weird proteins hijacks plants’ cellular plumbing

Many of the bacteria that ravage crops and threaten our food supply use a common strategy to cause disease: they inject a cocktail of harmful proteins directly into the plant's cells.

13 Sep 2023

Human post-implantation embryo models show promise in unraveling early development

Researchers evaluate post-implantation development in humans using embryo-like models based on genetically unmodified human naïve embryonic stem cells.

12 Sep 2023

Unlocking the secrets of our body's first line of defense against strep throat and more

Researchers have mapped the complex structures of secretory immunoglobulin A (sIgA) in interaction with human CD89 and Streptococcus pyogenes M4, offering new insights into how our first line of mucosal defense operates. The study reveals the intricate ways these components may influence each other, impacting both bacterial survival strategies and host immune responses.

10 Sep 2023

Unlocking the secret drivers of deadly pancreatic cancer: New target offers hope for treatment

Researchers identify a super-enhancer-regulated RNA-binding protein cascade that drives the growth of pancreatic ductal adenocarcinoma, a deadly form of pancreatic cancer. The discovery offers a promising new avenue for targeted therapy, potentially sidestepping severe side effects associated with other treatments.

10 Sep 2023

Mount Sinai researchers identify the structure of a special red blood cell transporter

Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs.

8 Sep 2023

Could your gut microbiome shape your teenage years? New study dives into the lifelong health impact

Research explores how the gut microbiota impacts critical areas of adolescent development, including mental health, metabolism, and skeletal growth. It suggests that understanding these interactions could lead to microbiome-based treatments for optimal growth and maturation.

7 Sep 2023

Aging reorganizes pancreas circadian transcriptome

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Reorganization of pancreas circadian transcriptome with aging."

5 Sep 2023

Gut feeling: How your microbiome could be shaping your mental health

Researchers in Biological Psychiatry delve into the complex relationship between the gut microbiome and mental health disorders like depression and bipolar disorder. The study explores how not just gut bacteria, but also lesser-known gut microorganisms such as viruses, fungi, and parasites, play a pivotal role in mood disorders.

5 Sep 2023

New blood test pinpoints Parkinson's disease through mitochondrial DNA damage

Researchers have developed a new blood test that measures mitochondrial DNA damage as a potential marker for Parkinson's disease (PD). The study shows the test could aid in diagnosing PD and assessing responses to LRRK2 kinase inhibitors, which may help in reducing mitochondrial damage in PD patients.

4 Sep 2023

Boosters slow antibody waning but hit a ceiling: Long-term COVID study reveals limits of immunity

The study tracks the long-term kinetics of antibody responses to SARS-CoV-2 after vaccination and infections in New York healthcare workers from 2020 to 2023. It reveals that antibody waning is slower after booster shots, but there's an upper limit to antibody levels, which gradually lowers with repeated SARS-CoV-2 exposures and vaccinations.

31 Aug 2023

Researchers unearth secrets of zinc transporter protein

A group of researchers has unearthed the secrets behind a tiny but crucial protein that shuttles zinc ions (Zn2+) within our bodies. The discovery offers a deeper understanding of how our cells maintain optimal health.

31 Aug 2023

Ion channel proteins can transiently rearrange into larger structures

A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a study led by researchers at Weill Cornell Medicine.

30 Aug 2023

Unlocking tumor immune evasion: IL1RL1+ Treg cells and CAFs collaborate for immunotherapy resistance

Researchers demonstrated that the crosstalk between IL1RL1+ regulatory T-cells (Treg) and cancer-associated fibroblasts (CAFs) drives the tissue repairing.

30 Aug 2023

Researchers unravel structure of MCM8/9 enzyme linked to infertility and cancer

Scientific research requires patience. The rewards are not always immediate, and the technology needed does not always exist. Michael A. Trakselis, Ph.D., professor and director of graduate affairs for the Department of Chemistry and Biochemistry at Baylor University, understands this.

29 Aug 2023

Innovative insights into effects of hematopoietic changes on colon cancer, unveiling therapeutic avenues

Researchers investigated whether bone marrow-derived cells contribute to colitis-associated colon cancer.

29 Aug 2023

Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

Researchers evaluated the use of a dual clustered regularly interspaced short palindromic repeats (CRISPR)-Cas3 system.

29 Aug 2023

Kennesaw State professor receives NIH grant to study epigenetic inheritance in nematodes

Kennesaw State University biology professor Brandon Carpenter was inspired to pursue a career in science because of an undergraduate research experience. With a recent grant from the National Institutes of Health (NIH), he'll provide a similar experience to his students.

25 Aug 2023

Two small molecule inhibitors can help improve precision, efficiency of CRISPR-Cas9 gene editing

A new study published in Nature Communications demonstrates how small molecule inhibitors can be used to improve the precision and efficiency of CRISPR-Cas9 gene editing.

25 Aug 2023

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

The interplay between human STING genotype and bacterial NADase activity.

22 Aug 2023

Study sheds light on how SARS-CoV-2 virus switches between replication and packaging

Immediately after the infection of a cell in the throat or lungs, the SARS-CoV-2 virus works very hard to replicate, using the human cell's metabolic pathways to produce its proteins and make sure that its genetic material (the RNA genome) is copied.

21 Aug 2023

Molecular & Structural Biology

A family of weird proteins hijacks plants’ cellular plumbing

Human post-implantation embryo models show promise in unraveling early development

Unlocking the secrets of our body's first line of defense against strep throat and more

Unlocking the secret drivers of deadly pancreatic cancer: New target offers hope for treatment

Mount Sinai researchers identify the structure of a special red blood cell transporter

Could your gut microbiome shape your teenage years? New study dives into the lifelong health impact

Aging reorganizes pancreas circadian transcriptome

Gut feeling: How your microbiome could be shaping your mental health

New blood test pinpoints Parkinson's disease through mitochondrial DNA damage

Boosters slow antibody waning but hit a ceiling: Long-term COVID study reveals limits of immunity

Researchers unearth secrets of zinc transporter protein

Ion channel proteins can transiently rearrange into larger structures

Unlocking tumor immune evasion: IL1RL1+ Treg cells and CAFs collaborate for immunotherapy resistance

Researchers unravel structure of MCM8/9 enzyme linked to infertility and cancer

Innovative insights into effects of hematopoietic changes on colon cancer, unveiling therapeutic avenues

Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

Kennesaw State professor receives NIH grant to study epigenetic inheritance in nematodes

Two small molecule inhibitors can help improve precision, efficiency of CRISPR-Cas9 gene editing

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

Study sheds light on how SARS-CoV-2 virus switches between replication and packaging

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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