Molecular & Structural Biology

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Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

A multidisciplinary study published in Nature has elucidated the structure of the machinery responsible for writing much of our "dark genome" -; the 98 percent of our DNA that has largely unknown biological function.

14 Dec 2023

Scientists unveil 3D structure of key immune system component

An international team of researchers from LMU and the Helmholtz Centre for Infection Research has visualized the structure of the so-called ASC speck.

8 Dec 2023

New insights into the structures formed during antibody aggregation through 3D domain swapping

Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development.

8 Dec 2023

Design modifications offer promise for safer and more effective mRNA therapeutics

Researchers have discovered that misreading of therapeutic mRNAs by the cell's decoding machinery can cause an unintended immune response in the body.

6 Dec 2023

New discovery unveils an additional layer of the CRISPR-Cas antiviral defense system

The recent publication in Science by Mogila, Tamulaitiene et al. represents a continuation of the successful scientific research conducted by Gintautas Tamulaitis' group.

4 Dec 2023

Navigating STXBP1-related disorders: Unraveling clinical and developmental outcomes

Researchers examined the combined patient-years of seizure and developmental histories in individuals with disorders related to the STXBP1 gene.

4 Dec 2023

CHOP researchers unlock 3D structure of crucial protein for cancer therapy

Chimeric Antigen Receptors (CARs) have opened up an exciting new field of therapeutic advancements for rare and difficult-to-treat cancers, as they have the ability to deliver targeted therapies that can kill tumor cells.

1 Dec 2023

New insights into evolution of the “little brain”

The evolution of higher cognitive functions in human beings has so far mostly been linked to the expansion of the neocortex – a region of the brain that is responsible, inter alia, for conscious thought, movement and sensory perception.

29 Nov 2023

Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas

Researchers demonstrated clustered regularly interspersed short palindromic repeats (CRISPR)-mediated elimination of glioblastoma (GBM) cells.

29 Nov 2023

Plant proteins found to mimic human immune signaling proteins

Researchers have shown that certain plant proteins resemble human signaling proteins of the immune system and can bind to their receptors.

23 Nov 2023

Antibiotics that target mitochondria may promote longevity

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, "Antibiotics that target mitochondria extend lifespan in C. elegans."

22 Nov 2023

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

The study investigates the role of epigenetic changes in GLP1R gene polymorphisms on metabolically healthy obesity (MHO), revealing that apart from genetic variations, DNA methylation significantly influences the occurrence of MHO.

20 Nov 2023

Study reveals surprising role of cerebellar nuclei in associative learning

Associative learning was always thought to be regulated by the cortex of the cerebellum, often referred to as the "little brain".

20 Nov 2023

New method for capturing proteins in nano-sized traps could revolutionize disease research

Proteins that form clumps occur in many difficult-to-treat diseases, such as ALS, Alzheimer's, and Parkinson's.

20 Nov 2023

Novel tool can help with analysis of single cell data

CITE-seq (cellular indexing of transcriptomes and epitopes) is an RNA sequencing-based method that simultaneously quantifies cell surface protein and transcriptomic data within a single cell readout.

17 Nov 2023

Alcohol consumption linked to accelerated biological aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Alcohol consumption and epigenetic age acceleration across human adulthood."

14 Nov 2023

Study uses cellulose sheets to map body's extracellular vesicles, unlocking disease insights

Study demonstrates the use of cellulose nanofiber sheets for spatial analysis of extracellular vesicles, revealing their geographical heterogeneity in the human body, which could advance the understanding and treatment of diseases.

14 Nov 2023

Traffic emissions disrupt gene expression in human olfactory cells

Exposure to ultrafine particles from traffic alters the expression of many genes in human olfactory mucosa cells, a new study shows.

14 Nov 2023

Neural circuits respond to rapid dopamine surges

Researchers assess the pharmacodynamics of dopamine signaling, brain connectivity/activity, and self-documented 'high' following methylphenidate exposure.v

14 Nov 2023

Researchers identify key factors involved in DNA repair mechanism

Researchers from Tokyo Metropolitan University have identified key factors in the mechanism behind DNA repair in our bodies.

12 Nov 2023

Molecular & Structural Biology

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

Scientists unveil 3D structure of key immune system component

New insights into the structures formed during antibody aggregation through 3D domain swapping

Design modifications offer promise for safer and more effective mRNA therapeutics

New discovery unveils an additional layer of the CRISPR-Cas antiviral defense system

Navigating STXBP1-related disorders: Unraveling clinical and developmental outcomes

CHOP researchers unlock 3D structure of crucial protein for cancer therapy

New insights into evolution of the “little brain”

Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas

Plant proteins found to mimic human immune signaling proteins

Antibiotics that target mitochondria may promote longevity

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

Study reveals surprising role of cerebellar nuclei in associative learning

New method for capturing proteins in nano-sized traps could revolutionize disease research

Novel tool can help with analysis of single cell data

Alcohol consumption linked to accelerated biological aging

Study uses cellulose sheets to map body's extracellular vesicles, unlocking disease insights

Traffic emissions disrupt gene expression in human olfactory cells

Neural circuits respond to rapid dopamine surges

Researchers identify key factors involved in DNA repair mechanism

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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