Molecular & Structural Biology

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Researchers develop new approach to efficiently produce versatile antibody therapies

A group of researchers has developed an approach to efficiently produce antibodies that can bind to two different target molecules simultaneously, a long-desired innovation in the field of cancer immunotherapy.

29 Aug 2017

Research reveals LEGO-like stacking of protein complexes

When hemoglobin undergoes just one mutation, the protein complexes stick to one another, stacking like LEGO blocks to form long, stiff filaments.

29 Aug 2017

Study provides better understanding of how estrogen regulates gene expression

Estrogen hormones regulate gene expression. They achieve this by first binding to estrogen receptor in the cell nucleus, which triggers the recruitment of different molecules called coactivators in specific order.

24 Aug 2017

Research shows how glutamine plays role in regulating cellular differentiation programs

The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs have to be turned on or off.

17 Aug 2017

Cryo-electron microscopy advances by Thermo Fisher Scientific drives structural biology research

Thermo Fisher Scientific, the world leader in serving science, has extended its leadership in cryo-electron microscopy (cryo-EM) with the introduction of two new instruments: the Thermo Scientific Krios G3i and the Thermo Scientific Glacios cryo-transmission electron microscopes (cryo-TEMs).

From Thermo Fisher Scientific Inc. 9 Aug 2017

Vanderbilt researchers unravel how bacterial toxin prevents DNA replication

One of the most potent toxins known acts by welding the two strands of the famous double helix together in a unique fashion which foils the standard repair mechanisms cells use to protect their DNA.

2 Aug 2017

DNA-sensing mechanism of innate immune system controls cellular senescence

Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due to the cell growing "old".

31 Jul 2017

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Sixty-four years ago, James Watson and Francis Crick described the now-iconic double helix structure of DNA.

29 Jul 2017

Structure of protein in salmon virus could inform strategies to treat flu in humans

The structure of a protein key to the survival and spread of a virus that affects salmon could inform strategies to treat the flu in humans, according to scientists at Rice University.

28 Jul 2017

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Using an array of modern biochemical and structural biology techniques, researchers from Boston University School of Medicine have begun to unravel the mystery of how acidity influences a small protein called serum amyloid A (SAA).

28 Jul 2017

Molecule plays essential role in establishing proper neural wiring in the cerebellum

Researchers at Hokkaido University have found that the molecule "L-gutamate/L-aspartate transporter" (GLAST) plays an essential role in establishing and maintaining proper neural wiring of Purkinje cells in the cerebellum.

28 Jul 2017

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

How can six and half feet of DNA be folded into the tiny nucleus of a cell? Researchers funded by the National Institutes of Health have developed a new imaging method that visualizes a very different DNA structure, featuring small folds of DNA in close proximity.

27 Jul 2017

Study identifies key component that allows deadly bacteria to spread antibiotic resistance

Antibiotic resistance of the bacterium Staphylococcus aureus is responsible for 11,300 deaths a year in the United States alone -- a figure that corresponds to half of all deaths caused by gram-positive resistant bacteria in that country.

26 Jul 2017

Molecular classification of gastric cancer subtypes could shape tailored treatment options

Molecular classification of the four distinct subtypes of gastric cancer could potentially shape tailored treatment options by helping to predict survival outcomes and patients' response to chemotherapy.

26 Jul 2017

Scientists find hints to a 'ghost' species of archaic humans in saliva

In saliva, scientists have found hints that a "ghost" species of archaic humans may have contributed genetic material to ancestors of people living in Sub-Saharan Africa today.

21 Jul 2017

Highly intricate visual system arises from simple blueprint present at birth, findings suggest

For decades, researchers have known that the primate brain is organized into "maps" for each of the different senses: one of the body for touch, one of the visual world for sight, one of tones for hearing.

19 Jul 2017

Unique 'Golden Hour' study details ultra-early immune response to trauma

Scientists from the University of Birmingham are carrying out pioneering research as part of a major £10 million study aimed at improving outcomes for patients who have suffered a traumatic injury.

19 Jul 2017

Researchers study molecular mechanisms responsible for Alzheimer's disease

Members of the Faculty of Fundamental Medicine at the Lomonosov Moscow State University have determined the structure of a peptide complex, formed in the brain at the early stages of Alzheimer's disease progression.

14 Jul 2017

CRISPR technology shows potential as a “molecular recorder” through DNA encoded movie

The researchers from Harvard University, Seth L. Shipman, Jeff Nivala, Jeffrey D. Macklis and George M. Church, believe that their study is a major step forward to a "molecular recorder" that may someday make it possible to get read-outs, has published online their proof-of-concept on July 12, 2017, in the journal Nature.

14 Jul 2017

New technique reveals detailed structure of sweat glands

The basic structure of human sweat glands consists of a coiled secretory region deep in the skin and then a tube or duct that conveys the sweat to a pore at the skin surface.

10 Jul 2017

Molecular & Structural Biology

Researchers develop new approach to efficiently produce versatile antibody therapies

Research reveals LEGO-like stacking of protein complexes

Study provides better understanding of how estrogen regulates gene expression

Research shows how glutamine plays role in regulating cellular differentiation programs

Cryo-electron microscopy advances by Thermo Fisher Scientific drives structural biology research

Vanderbilt researchers unravel how bacterial toxin prevents DNA replication

DNA-sensing mechanism of innate immune system controls cellular senescence

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Structure of protein in salmon virus could inform strategies to treat flu in humans

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Molecule plays essential role in establishing proper neural wiring in the cerebellum

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

Study identifies key component that allows deadly bacteria to spread antibiotic resistance

Molecular classification of gastric cancer subtypes could shape tailored treatment options

Scientists find hints to a 'ghost' species of archaic humans in saliva

Highly intricate visual system arises from simple blueprint present at birth, findings suggest

Unique 'Golden Hour' study details ultra-early immune response to trauma

Researchers study molecular mechanisms responsible for Alzheimer's disease

CRISPR technology shows potential as a “molecular recorder” through DNA encoded movie

New technique reveals detailed structure of sweat glands

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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