Molecular & Structural Biology

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Study uncovers link between corticosteroid receptors and ciliary, neuroplasticity genes in the brain

Chronic stress is a well-known cause for mental health disorders. New research has moved a step forward in understanding how glucocorticoid hormones ('stress hormones') act upon the brain and what their function is.

6 Aug 2021

Research reveals a microRNA network as putative mediators of myocardial reductive stress

Last year, University of Alabama at Birmingham researchers reported that reductive stress - an imbalance in the normal oxidation/reduction homeostasis - caused pathological changes associated with heart failure in a mouse model.

6 Aug 2021

Researchers reveal key differences in the fragmentation of chiral biomolecules

By combining mass spectroscopy with further analytical and simulation techniques, researchers have revealed key differences in the fragmentation of dipeptide biomolecules with different chiral structures.

6 Aug 2021

SMC protein complex plays a decisive role in the dynamics of holocentromeres

Monocentromeres are typical for the chromosomes of most animals and plants. The centromere is necessary for the transport of the chromosomes and represents the connection point between the chromatids.

6 Aug 2021

Study: IgG antibodies against SARS-CoV-2 remain stable, or even increase, seven months after infection

The levels of IgG antibodies against SARS-CoV-2 Spike protein remain stable, or even increase, seven months after infection, according to a follow-up study in a cohort of healthcare workers coordinated by the Barcelona Institute for Global Health, an institution supported by "la Caixa" Foundation, in collaboration with the Hospital Clinic of Barcelona.

6 Aug 2021

Researchers develop a novel process for producing pure RNA

Researchers at the University of Massachusetts Amherst recently unveiled their discovery of a new process for making RNA.

6 Aug 2021

Scientists decipher missing pieces of the reward system puzzle to increase motivation

Our motivation to put effort into achieving a goal is controlled by a reward system wired in the brain. However, many neuropathological conditions impair the reward system, diminishing the will to work.

6 Aug 2021

Study reveals structural differences and unique polymorphs in amyloid-β fibrils

Alzheimer's disease (AD) is a neurological condition leading to dementia that worsens with age as patients exhibit cognitive, memory, and psychological deficits.

5 Aug 2021

UAB researchers identify potential therapeutic target for ovarian cancer

A gene called DOT1L appears to play a role in progression and severity of ovarian cancer, and inhibitors of the DOT1L enzyme may offer a new therapeutic approach for the disease, University of Alabama at Birmingham researchers say in a study published in the journal Oncogenesis.

5 Aug 2021

Using two different CRISPR enzymes to develop a faster and easier COVID-19 diagnostic test

Frequent, rapid testing for COVID-19 is critical to controlling the spread of outbreaks, especially as new, more transmissible variants emerge.

5 Aug 2021

Researchers use tiny worm to trace the development of human brain

Researchers at Sinai Health have used a tiny worm to track how an animal’s brain changes throughout its lifetime, shedding new light on how human brains develop.

5 Aug 2021

Study offers molecular views on how olfactory receptors work

All senses must reckon with the richness of the world, but nothing matches the challenge faced by the olfactory system that underlies our sense of smell.

4 Aug 2021

Scientists identify new therapeutic target for several aggressive cancers

A protein in tumor cells could be targeted to treat some types of aggressive cancer including brain, blood, skin, and kidney, new research has shown.

4 Aug 2021

Key protein linked to both physical fitness in youth and diseases of old age

Researchers from Johns Hopkins Medicine say they have added to evidence that a protein called CaMKII improves strength, endurance, muscle health and fitness in young animals.

4 Aug 2021

Research shows how neurons learn to pick the most energy-efficient perturbations

Brains have evolved to do more with less. Take a tiny insect brain, which has less than a million neurons but shows a diversity of behaviors and is more energy- efficient than current AI systems.

3 Aug 2021

Study shows pharmacological rescue of mitochondrial defect related to Parkinson's disease

Treating mice that have a Parkinson's disease-causing mutation with a small molecule compound restores the removal of damaged mitochondria from their brain cells, shows a study published today in eLife.

3 Aug 2021

Study reveals novel mechanism underlying infantile spasms-associated learning deficits

Researchers report that infantile spasms, a rare but serious seizure disorder in babies, appear to be the result of a molecular pathway gone awry.

3 Aug 2021

Experimental model shows how topological defects in the mesothelium affect ovarian cancer metastasis

Ovarian cancer devastates more than 20,000 women in the U.S. every year, due in part to its tendency to evade detection and present after metastatic spread. A key element to slowing metastasis is understanding the mechanisms of how tumor cells invade tissues.

3 Aug 2021

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Researchers at the University of Virginia School of Medicine have overturned conventional wisdom on the workings of vital hormone receptors within cells, a finding that could boost drug development for diabetes and related metabolic disorders, cancer and other diseases.

31 Jul 2021

Melanoma mutations result from a chemical conversion in DNA fueled by sunlight, study reports

The mutations that give rise to melanoma result from a chemical conversion in DNA fueled by sunlight - not just a DNA copying error as previously believed, reports a study by Van Andel Institute scientists published today in Science Advances.

30 Jul 2021

Molecular & Structural Biology

Study uncovers link between corticosteroid receptors and ciliary, neuroplasticity genes in the brain

Research reveals a microRNA network as putative mediators of myocardial reductive stress

Researchers reveal key differences in the fragmentation of chiral biomolecules

SMC protein complex plays a decisive role in the dynamics of holocentromeres

Study: IgG antibodies against SARS-CoV-2 remain stable, or even increase, seven months after infection

Researchers develop a novel process for producing pure RNA

Scientists decipher missing pieces of the reward system puzzle to increase motivation

Study reveals structural differences and unique polymorphs in amyloid-β fibrils

UAB researchers identify potential therapeutic target for ovarian cancer

Using two different CRISPR enzymes to develop a faster and easier COVID-19 diagnostic test

Researchers use tiny worm to trace the development of human brain

Study offers molecular views on how olfactory receptors work

Scientists identify new therapeutic target for several aggressive cancers

Key protein linked to both physical fitness in youth and diseases of old age

Research shows how neurons learn to pick the most energy-efficient perturbations

Study shows pharmacological rescue of mitochondrial defect related to Parkinson's disease

Study reveals novel mechanism underlying infantile spasms-associated learning deficits

Experimental model shows how topological defects in the mesothelium affect ovarian cancer metastasis

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Melanoma mutations result from a chemical conversion in DNA fueled by sunlight, study reports

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