Molecular & Structural Biology

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Researchers develop an integrative approach to boost accuracy of mosquito vector surveillance

A team of researchers from the National University of Singapore, led by Assistant Professor Nalini Puniamoorthy from the Department of Biological Sciences, has developed an integrative approach that increases the accuracy of mosquito surveillance and management.

20 Aug 2021

Northwestern scientists discover remarkable longevity in a subset of mitochondrial proteins

Northwestern Medicine investigators have discovered that a subset of proteins in mitochondria of brain and heart cells are long-lived, supporting the long-term stability of mitochondrial complex architecture.

20 Aug 2021

Regular physical exercise modulates iron metabolism in Alzheimer’s mouse model

A recent experimental study shows how regular physical exercise modulates iron metabolism in both the brain and the muscles.

20 Aug 2021

SARS-CoV-2 mutations alter dynamics of neutralizing antibodies

A new study describes how monoclonal antibodies raised against SARS-CoV-2 are affected by mutations in the antibody binding site.

20 Aug 2021

SARS-CoV-2 lambda variant escapes immune response via spike mutations

A new study explores the mechanism by which the SARS-CoV-2 lambda variant has acquired immune evasion capabilities above that of the wildtype.

20 Aug 2021

Researchers identify key protein that plays an essential role in male fertility

Mammalian sperm cannot fertilize an egg from the get-go. It's an ability acquired only after insemination, during passage through the female reproductive tract, and requires two consecutive, time-sensitive processes to provide sperm with the physical and biochemical traits necessary to complete their fundamental job.

20 Aug 2021

New mouse line reveals the state of protein balance in the mammalian brain for the first time

Proteins are the "tools" of our cells – they are essential to all vital tasks. However, they are only able to do their jobs if they fold correctly and adopt their respective, very specific 3D structure.

20 Aug 2021

Researchers use ancient mammalian proteins to develop mRNA delivery system

Using a family of mammalian proteins adopted from ancient retroviral legacy genes, researchers have developed a novel system for programmable intracellular mRNA delivery.

20 Aug 2021

Npas4 gene may be a master timekeeper for the brain's circadian clock

A gene called Npas4, already known to play a key role in balancing excitatory and inhibitory inputs in brain cells, appears to also be a master timekeeper for the brain's circadian clock, new research led by UT Southwestern scientists suggests.

20 Aug 2021

Research could enable clinicians to produce patient-matched cells for treating muscle-related diseases

Investigators who previously developed a recipe for turning skin cells into primitive muscle-like cells that can be maintained indefinitely in the lab without losing the potential to become mature muscle have now uncovered how this recipe works and what molecular changes it triggers within cells.

19 Aug 2021

Researchers discover glycan 'gates' that open to allow SARS-CoV-2 entry

Since the early days of the COVID pandemic, scientists have aggressively pursued the secrets of the mechanisms that allow severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter and infect healthy human cells.

19 Aug 2021

Scientists develop a new way to deliver molecular therapies to cells

Researchers from MIT, the McGovern Institute for Brain Research at MIT, the Howard Hughes Medical Institute, and the Broad Institute of MIT and Harvard have developed a new way to deliver molecular therapies to cells.

19 Aug 2021

CRISPR screening tool pinpoints new therapeutic target to treat acute myeloid leukemia

A CRISPR screening tool identified a new therapeutic target to treat acute myeloid leukemia (AML) that has the potential to leave patients with fewer side effects than current approaches, according to a new study from Penn Medicine published online in Molecular Cell.

18 Aug 2021

Scientists propose innovative method to test the effectiveness of coronavirus medicines

South Ural State University scientists have proposed an innovative method for testing the effectiveness of medicines for coronavirus. According to the researchers, it is necessary to focus on the maximum coincidence of the ligand and the receptor. The results of the work have been published in the highly-rated journal "Molecules"(Q1).

18 Aug 2021

Protein implicated in tumor growth may protect against neurodegenerative diseases

Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease.

17 Aug 2021

Making the nanobody big again for Cryo-EM

Researchers describe the method that allows high-resolution structure determination of small proteins by single-particle cryo-EM using a Legobody.

17 Aug 2021

Study provides insight into fitness effects of genomic structural variants in natural populations

Molecular geneticists have known for about a decade that genomic structural variants can play important roles in the adaptation and speciation of both plants and animals, but their overall influence on the fitness of plant populations is poorly understood.

16 Aug 2021

SFI researchers take a broader view of life’s multiple origins

The history of life on Earth has often been likened to a four-billion-year-old torch relay. One flame, lit at the beginning of the chain, continues to pass on life in the same form all the way down.

16 Aug 2021

Brain’s structural and functional alignment can vary with sex, age and may be genetic, study suggests

The degree to which the brain's wiring aligns with its patterns of activity can vary with sex and age, and may be genetic, suggests a study published by Weill Cornell Medicine investigators. The study finds that this alignment may also have implications on cognition.

16 Aug 2021

Small protein prevents immune system from destroying pancreatic cells in type 1 diabetes-prone mice

A new study has shown that treating type 1 diabetes-prone mice with the small protein MOTS-c prevented the immune system from destroying insulin-producing pancreatic cells, effectively preventing the onset of the autoimmune disease.

16 Aug 2021

Molecular & Structural Biology

Researchers develop an integrative approach to boost accuracy of mosquito vector surveillance

Northwestern scientists discover remarkable longevity in a subset of mitochondrial proteins

Regular physical exercise modulates iron metabolism in Alzheimer’s mouse model

SARS-CoV-2 mutations alter dynamics of neutralizing antibodies

SARS-CoV-2 lambda variant escapes immune response via spike mutations

Researchers identify key protein that plays an essential role in male fertility

New mouse line reveals the state of protein balance in the mammalian brain for the first time

Researchers use ancient mammalian proteins to develop mRNA delivery system

Npas4 gene may be a master timekeeper for the brain's circadian clock

Research could enable clinicians to produce patient-matched cells for treating muscle-related diseases

Researchers discover glycan 'gates' that open to allow SARS-CoV-2 entry

Scientists develop a new way to deliver molecular therapies to cells

CRISPR screening tool pinpoints new therapeutic target to treat acute myeloid leukemia

Scientists propose innovative method to test the effectiveness of coronavirus medicines

Protein implicated in tumor growth may protect against neurodegenerative diseases

Making the nanobody big again for Cryo-EM

Study provides insight into fitness effects of genomic structural variants in natural populations

SFI researchers take a broader view of life’s multiple origins

Brain’s structural and functional alignment can vary with sex, age and may be genetic, study suggests

Small protein prevents immune system from destroying pancreatic cells in type 1 diabetes-prone mice

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