Gene News and Research

Latest Gene News and Research

Genetic variations associated with increased risk for osteonecrosis in young ALL patients

Variations in genes involved in normal bone development are associated with an 8- to 15-fold increased risk for osteonecrosis in young patients with acute lymphoblastic leukemia (ALL), according to research led by St. Jude Children's Research Hospital and Children's Oncology Group investigators.

7 Dec 2015

Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

New research adds to a growing body of evidence that gene therapy, an experimental technique that involves correcting or replacing a person's mutated or malfunctioning genes, may improve health outcomes for patients with inherited bleeding and immune disorders as well as some forms of blood cancer.

7 Dec 2015

Study identifies new recurrent genetic mutations involved in origin of AML

Mariam Ibáñez, lecturer at Universidad Cardenal Herrera CEU (CEU Cardenal Herrera University, UCH-CEU) and biologist at "La Fe" Hospital in Valencia used massive sequencing techniques to identify new recurrent genes mutations involved in the origin of acute myelogenous leukemia (AML).

1 Dec 2015

Lexicon announces top-line results from TELECAST Phase 3 study of telotristat etiprate

Lexicon Pharmaceuticals, Inc. announced today that top-line data from its TELECAST Phase 3 study showed results of telotristat etiprate in treating carcinoid syndrome in cancer patients with metastatic neuroendocrine tumors consistent with the clinical benefit observed in its pivotal TELESTAR study.

1 Dec 2015

Discovery may lead to potential new therapeutic approach to eradicate blood cancers

An international team of scientists, headed by researchers at UC San Diego School of Medicine and UC San Diego Moores Cancer Center, report that decreases in a specific group of proteins trigger changes in the cancer microenvironment that accelerate growth and development of therapy-resistant cancer stem cells (CSCs).

1 Dec 2015

TGen, Barrow researchers identify genetic risk factors linked to stress-induced cardiomyopathy

Researchers at the Translational Genomics Research Institute and Barrow Neurological Institute have for the first time identified genetic risk factors that are linked to stress-induced cardiomyopathy (SIC), a rare type of heart disease.

1 Dec 2015

Low levels of BRCA1 protein in the brain linked to dementia

Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer's disease. The results, published in Nature Communications, suggest that low levels of BRCA1 protein in the brain may contribute to dementia.

1 Dec 2015

Scientists can accurately measure microbial growth rates inside gastrointestinal tracts

For the first time, scientists can accurately measure population growth rates of the microbes that live inside mammalian gastrointestinal tracts, according to a new method reported in Nature Communications by a team at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School.

1 Dec 2015

Johns Hopkins researchers develop method to turn stem cells into retinal ganglion cells

Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, the type of nerve cells located within the retina that transmit visual signals from the eye to the brain. Death and dysfunction of these cells cause vision loss in conditions like glaucoma and multiple sclerosis.

1 Dec 2015

Mutant protein responsible for cystic fibrosis talks to wrong cellular neighbors

Scientists at The Scripps Research Institute have found evidence that a mutant protein responsible for most cases of cystic fibrosis is so busy "talking" to the wrong cellular neighbors that it cannot function normally and is prematurely degraded.

1 Dec 2015

DNA sequence variation can influence gene activity in developing human brain

An international research collaboration has shed new light on how DNA sequence variation can influence gene activity in the developing human brain.

1 Dec 2015

Memorandum of understanding signed between Cell Therapy Catapult and Kanagawa Prefecture

The Cell Therapy Catapult, the UK organisation dedicated to the growth of the UK cell and gene therapy industry by bridging the gap between scientific research and commercialisation, today announces the signing of a memorandum of understanding with the Kanagawa Prefecture of Japan.

30 Nov 2015

Research sheds light on genetic factors involved in autoimmune diseases

A collaboration between researchers at the Babraham Institute and the University of Manchester has mapped the physical connections occurring in the genome to shed light on the parts of the genome involved in autoimmune diseases. Using a new technique, called Capture Hi-C, the team revealed novel insights into how changes in the genetic sequence have a biological effect and increase the risk of disease.

30 Nov 2015

Human Longevity announces acquisition of Cypher Genomics

Human Longevity, Inc., the genomics-based, technology-driven company, announced today that the company has acquired Cypher Genomics, Inc., a leading genome informatics company offering highly accurate, rapid and robust human genomic interpretation software solutions.

30 Nov 2015

Scientists discover genetic causes of Goldenhar syndrome

Some children are born with cleft palates and, of those children, some have an asymmetrical face and a malformed ear. A team of scientists led by Berlin-based researcher Enno Klußmann of the Max Delbrück Center for Molecular Medicine has taken an important step towards discovering the genetic causes of this condition, known as Goldenhar syndrome.

30 Nov 2015

Could statins treat muscular dystrophy? An interview with Dr. Nick Whitehead and Dr Stan Froehner

In addition to their well established cholesterol lowering benefits, statins also have potent anti-inflammatory, anti-fibrotic and antioxidant effects, which continue to be identified in a wide range of diseases.

30 Nov 2015

Researchers discover drug target and genetic pathway for graft-versus-host disease

A Seattle Children's Research Institute lab has discovered a genetic pathway that can be targeted with existing drugs to prevent graft-versus-host disease (GVHD), a common and deadly complication of bone marrow transplants.

30 Nov 2015

New research reveals how gaps between gene interactions influence disease risk

New research from The University of Manchester and the Brabraham Institute has revealed how gaps between genes interact to influence the risk of acquiring diseases such as arthritis and type 1 diabetes.

30 Nov 2015

Rare variants linked with Parkinson’s disease

Researchers using exome sequencing in families with Parkinson’s disease have identified two genes that could be associated with the condition.

27 Nov 2015

Exploring how absence of ASS1 protein affects sick children may provide a 'lens' on cancer

What can a rare genetic childhood disease teach us about cancer? Dr. Ayelet Erez of the Weizmann Institute of Science's Department of Biological Regulation says: "A single-mutation disease can act as a 'lens.' If we find exactly what malfunctions in the sick child, we can zoom in and understand the role of the same gene among the many genetic changes that accompany cancer."

26 Nov 2015

Gene News and Research

Latest Gene News and Research

Genetic variations associated with increased risk for osteonecrosis in young ALL patients

Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

Study identifies new recurrent genetic mutations involved in origin of AML

Lexicon announces top-line results from TELECAST Phase 3 study of telotristat etiprate

Discovery may lead to potential new therapeutic approach to eradicate blood cancers

TGen, Barrow researchers identify genetic risk factors linked to stress-induced cardiomyopathy

Low levels of BRCA1 protein in the brain linked to dementia

Scientists can accurately measure microbial growth rates inside gastrointestinal tracts

Johns Hopkins researchers develop method to turn stem cells into retinal ganglion cells

Mutant protein responsible for cystic fibrosis talks to wrong cellular neighbors

DNA sequence variation can influence gene activity in developing human brain

Memorandum of understanding signed between Cell Therapy Catapult and Kanagawa Prefecture

Research sheds light on genetic factors involved in autoimmune diseases

Human Longevity announces acquisition of Cypher Genomics

Scientists discover genetic causes of Goldenhar syndrome

Could statins treat muscular dystrophy? An interview with Dr. Nick Whitehead and Dr Stan Froehner

Researchers discover drug target and genetic pathway for graft-versus-host disease

New research reveals how gaps between gene interactions influence disease risk

Rare variants linked with Parkinson’s disease

Exploring how absence of ASS1 protein affects sick children may provide a 'lens' on cancer

eBook: Using iPSCs models for human disease research and drug discovery eBook

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research