Gene News and Research

Latest Gene News and Research

UCSD first to treat glioma with investigational viral vector

UC San Diego Moores Cancer Center researchers and surgeons are among the first in the nation to treat patients with recurrent brain cancer by directly injecting an investigational viral vector into their tumor. The treatment is being developed by a local San Diego Company, Tocagen Inc.

2 Mar 2012

First study to focus on platelet genetics in African Americans

Researchers, led by scientists from Johns Hopkins, have found five previously unknown gene mutations believed to be associated with elevated blood platelet counts in African-Americans, findings they say could someday lead to the development of new drugs to help prevent coronary artery disease.

2 Mar 2012

Planarian flatworms reveal new insights into stem cell biology

Devising a novel method to identify potential genetic regulators in planarian stem cells, Whitehead Institute scientists have determined which of those genes affect the two main functions of stem cells. Three of the genes are particularly intriguing because they code for proteins similar to those known to regulate mammalian embryonic stem cells. Such genetic similarity makes planarians an even more attractive model for studying stem cell biology in vivo.

2 Mar 2012

Report highlights benefits of Nuvilex's cell encapsulation technology for diabetes

Nuvilex, Inc., an emerging biotechnology provider of cell and gene therapy solutions, today provided additional details based on the Goldman Small Cap Research report issued February 29, 2012, that highlighted the company's cell encapsulation technology and its benefits for treating chronic diseases such as diabetes.

2 Mar 2012

Study uncovers how FoxO1 protein contributes to heart disease in patients with diabetes

UT Southwestern Medical Center cardiologists have uncovered how a specific protein's previously unsuspected role contributes to the deterioration of heart muscle in patients with diabetes. Investigators in the mouse study also have found a way to reverse the damage caused by this protein.

2 Mar 2012

Alternative subunits generate different functional subtypes of RNA polymerases

Indiana University biologists have found that specific types of RNA polymerase enzymes, the molecular machines that convert DNA into RNA, can differ in function based on variation in the parts -- in this case protein subunits -- used to assemble those machines.

2 Mar 2012

p14 ARF protein also regulates tumor-induced angiogenesis

Researchers at Winship Cancer Institute of Emory University have identified a new function for a gene that normally prevents the development of cancer.

2 Mar 2012

Scientists identify genetic defect responsible for TAR Syndrome

Universitätsmedizin Berlin in collaboration with the Sanger Institute in Cambridge and other cooperation partners in Belgium, the Netherlands and France, were able to identify a genetic defect that is responsible for the development of TAR Syndrome, a congenital malformation of the skeleton and blood.

1 Mar 2012

Mayo researchers gain insights into function of histone chaperones

Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they have determined the 3-D structure and interactions of the histone chaperone Rtt106 down to the atomic details.

1 Mar 2012

Metastatic melanoma patients with specific genetic mutation benefit from vemurafenib

A report published this week in the New England Journal of Medicine shows that the 50 percent of metastatic melanoma patients with a specific genetic mutation benefit from the drug Vemurafenib - increasing median survival from about 6 months to 15.9 months. In patients who responded, the drug stopped cancer progression for a median 6.7 months.

1 Mar 2012

Similar mechanisms drive changes in puberty

It's one of life's special moments: a child finds a fat caterpillar, puts it in a jar with a twig and a few leaves, and awakens one day to find the caterpillar has disappeared and an elegant but apparently lifeless case now hangs from the twig.

1 Mar 2012

Study examines mRNA transcripts in the sperm of fruitflies and humans

It had long been assumed that the human sperm cell's mission in life ended once it had transferred its freight of parental DNA to the egg. More recently however, other components of sperm have been implicated in fertilization, and perhaps even in subsequent embryonic development.

1 Mar 2012

ACTB and ACTG1 actin genes cause Baraitser-Winter syndrome

Scientists from Seattle Children's Research Institute and the University of Washington, in collaboration with the Genomic Disorders Group Nijmegen in the Netherlands, have identified two new genes that cause Baraitser-Winter syndrome, a rare brain malformation that is characterized by droopy eyelids and intellectual disabilities.

1 Mar 2012

HDAC2 enzyme could be a potential target for new Alzheimer's drugs

MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer's symptoms.

1 Mar 2012

Researchers discover mechanism by which lead alters nerve cells in the brain

Exposure to lead wreaks havoc in the brain, with consequences that include lower IQ and reduced potential for learning. But the precise mechanism by which lead alters nerve cells in the brain has largely remained unknown.

1 Mar 2012

Brain mitochondria are dysfunctional in early-stage Alzheimer's

Mitochondria -- subunits inside cells that produce energy -- have long been thought to play a role in Alzheimer's disease. Now Mayo Clinic researchers using genetic mouse models have discovered that mitochondria in the brain are dysfunctional early in the disease.

1 Mar 2012

iBio receives U.S. patent for fusion-protein vaccine technology

iBio, Inc. today announced issuance of a US patent covering the use of iBio's proprietary fusion-protein technology in combination with influenza virus antigens for vaccine product applications.

29 Feb 2012

CU professor to interview epilepsy sufferers and their families in depth

Sara Shostak, assistant professor in the department of sociology, along with principal investigator Ruth Ottman, professor of epidemiology at Columbia University, and other collaborators were recently awarded a $2 million grant from The National Institute of Neurological Disorders and Stroke (NINDS) to learn more about these questions.

29 Feb 2012

Scientists discover that sperm do not function like olfactory cells

According to a 2003 study by German and American scientists, a component of the Lily of the Valley scent known as Bourgeonal alters the calcium balance of human sperm and attracts the sperm. The "Lily of the Valley phenomenon" - also the title of a book about smelling - was born as a result of this discovery that sperm act as swimming olfactory cells which follow a "scent trail" laid by the egg. However, a detailed explanation for the Lily of the Valley phenomenon remained illusive as neither Bourgeonal nor other scents could be identified in the female sex organ.

29 Feb 2012

WUSM to study children with weakened immune systems

Not all viruses make us sick. But which ones are friends and which ones are foes? Researchers at Washington University School of Medicine in St. Louis have received a five-year, $3.3 million grant to study children with weakened immune systems to identify the viruses that make children sick.

29 Feb 2012