Metabolism News and Research

Latest Metabolism News and Research

Understanding the mechanisms behind alcohol-associated liver disease

A newly published review in eGastroenterology compiles recent research on alcohol-associated liver disease (ALD), offering an overview of its pathogenesis and efforts to better understand this condition.

19 Dec 2024

Free cholesterol in HDL linked to increased cardiovascular disease risk

Houston Methodist researchers have discovered that certain components of so-called "good" cholesterol -- high-density lipoproteins (HDL) – may be associated with an increased prevalence of cardiovascular disease.

19 Dec 2024

A novel approach to combatting prostate cancer

New research by a team of Indiana University School of Medicine scientists and their collaborators has uncovered a novel vulnerability in prostate cancer animal models that starves prostate tumors of critical nutrients and stunts their growth, which could lead to the development of new treatments for the deadly disease.

19 Dec 2024

AI-based aging clocks offer insights into health and lifespan

Researchers at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London have conducted a comprehensive study to evaluate artificial intelligence based aging clocks, which predict health and lifespan using data from blood.

18 Dec 2024

Natural nutrients nicotinamide and pyridoxine reverse muscle aging

Researchers identified nicotinamide (NAM) and pyridoxine (PN) as safe, synergistic nutrients that restore muscle stem cell function, reversing age-related muscle degeneration in mice and humans.

18 Dec 2024

New drug approach shows promise in treating metabolic liver diseases

A MedUni Vienna study has identified a new approach to the drug treatment of metabolic liver diseases. In an experimental study, pharmacological inhibition of an enzyme that plays a central role in fat metabolism promoted liver health reduced liver fat, inflammation and fibrotic remodeling (connective tissue scarring).

18 Dec 2024

New therapies and technologies provide hope for age-related fertility challenges

Scientists explore emerging strategies to combat reproductive aging, highlighting promising therapies and technologies to improve fertility in later life.

17 Dec 2024

Study reveals nasal fungi diversity in allergy and asthma patients

Nearly a quarter of Portuguese adults have allergies that cause a runny nose. This respiratory disease, formally called allergic rhinitis and frequently associated with asthma, is a common problem around the world, and the upper airway is a key target for research into the underlying disease processes.

17 Dec 2024

Nutrient metabolism regulates T cell exhaustion and therapy potential

Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic changes in immunity.

17 Dec 2024

LECO Instruments UK Ltd. announces a new training and research collaboration with the Liverpool Training Centre for Metabolomics

LECO Instruments UK Ltd., a subsidiary of USA-based LECO Corporation, is pleased to announce a new and exciting training and research collaboration with the Liverpool Training Centre for Metabolomics and Centre for Metabolomics Research at the University of Liverpool. These centers are internationally recognized for their expertise in the development of analytical chemistry and software tools and their metabolomic applications across the biological disciplines.

From LECO Corporation 17 Dec 2024

Study reveals tumor and immune cell interactions in craniopharyngiomas

Craniopharyngiomas are brain tumors that negatively impact the hormonal function of the nearby pituitary.

16 Dec 2024

Targeting brain enzyme may offer new treatment for obesity

Endocannabinoids in the brain play a key role in food intake and energy use. Modulating the action of these molecules could help fight obesity, say researchers at Université de Montréal's affiliated hospital research center.

16 Dec 2024

How moderate coffee consumption reduces cardiovascular disease risk

Researchers examine the impact of coffee intake on cardiovascular disease.

16 Dec 2024

Research sheds light on how hypoxia affects T cell function in cancer

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ineffective.

14 Dec 2024

Unraveling the mystery of drug-induced liver injury

DILI is broadly categorized into intrinsic and idiosyncratic types. Intrinsic hepatotoxins, such as APAP, cause dose-dependent injury, while idiosyncratic DILI involves complex immune and metabolic interactions that remain poorly understood.

13 Dec 2024

Disrupting the circadian rhythm of glioblastoma slows tumor growth, study says

Virtually every cell in the human body has an internal clock. These clocks take their cues from a central clock in the brain. In a normal, biological process called synchrony, the central clock coordinates daily rhythms around the body, so that every cell and tissue recognizes the same external time of day.

13 Dec 2024

Key to LDL clearance uncovered: Structural details of apoB100-LDLR binding emerge

Researchers reveal the structural details of apoB100's interaction with LDL receptors, offering insights into LDL dimerization and potential treatments for familial hypercholesterolemia.

12 Dec 2024

Lipid imbalances hold the key to chronic inflammation in colon cancer

Scientists uncover how disrupted lipid metabolism fuels chronic inflammation in colorectal cancer, offering insights into new therapeutic strategies targeting pro-inflammatory and pro-resolving lipid imbalances.

12 Dec 2024

New study identifies potential target for treating diabetic cardiomyopathy

Some patients with diabetes develop a serious condition known as diabetic cardiomyopathy, which is slow and cannot be directly attributed to hypertension or other cardiovascular disorders.

12 Dec 2024

Mediterranean plants show promise for cardiovascular disease treatment

A study initiated from a final degree project at the Universitat Autònoma de Barcelona, with the involvement of researchers from the INc-UAB, the University of Barcelona and Cuban and Chilean institutions, has resulted in an exhaustive bibliographic review of a group of Mediterranean plants, whose active principles are attributed pharmacological actions in the field of cardiovascular diseases most affecting the population.

12 Dec 2024