Pharmacology News and Research

Latest Pharmacology News and Research

Inside the tactical tug of war over the controversial Alzheimer’s drug

The drug industry, patient advocates, and congressional Republicans have all attacked federal officials' decision to decline routine Medicare coverage for a controversial Alzheimer's drug.

16 Feb 2022

Human nose organoids provide better understanding of the first steps toward SARS-CoV-2 infection

Preclinical models that recapitulate aspects of human airway disease are essential for the advancement of novel therapeutics and vaccines.

16 Feb 2022

Phase one study of oral SARS-CoV-2 antiviral agent nirmatrelvir

A recent study posted to the medRxiv* preprint server reported the phase one pharmacokinetic and safety data of nirmatrelvir/ritonavir to facilitate its rapid progression to the last stages of clinical trials in coronavirus disease 2019 (COVID-19) patients with mild to moderate disease.

14 Feb 2022

Challenges in safely deprescribing common anticholinergic drugs

Medications with anticholinergic properties have been consistently associated with a wide range of adverse outcomes for older adults including cognitive impairment, yet these drugs continue to be commonly prescribed for depression, urinary incontinence, irritable bowel syndrome and Parkinson's disease.

11 Feb 2022

Biological events occurring during puberty trigger sex differences in learning and memory

New research from the University of California, Irvine reveals that sex differences in learning and memory mechanisms are triggered by biological events occurring during puberty.

10 Feb 2022

Researchers reveal new therapeutic way to block oncogenic RAS mutants

As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O'Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way to block a protein that is frequently mutated in cancers.

9 Feb 2022

UCI case report: Antihistamines may provide relief for people suffering from long COVID-19 symptoms

Antihistamines may provide relief for the millions of people suffering from the painful, debilitating symptoms of long COVID-19 that impair daily functioning.

9 Feb 2022

Prevalence of genetic susceptibility to cardiac arrhythmia may be underestimated, study says

By sequencing known genes associated with cardiac arrhythmia risk in more than 20,000 people without an indication for genetic testing, scientists were able to identify pathogenic and likely pathogenic variants in nearly one percent of individuals, according to a study published in Circulation.

9 Feb 2022

Paracetamol use increases blood pressure, study shows

Long-term paracetamol use could increase the risk of heart disease and strokes in people with high blood pressure, a study suggests.

7 Feb 2022

Colchicine holds promise to reduce the risk of severe COVID-19

A recent article, published in Rheumatology and Therapy, reviews the potent evidence of colchicine against the SARS-CoV-2 infection.

7 Feb 2022

USF receives NIH Training Grant to prepare next generation of translational researchers

The University of South Florida recently received a highly competitive National Institutes of Health Institutional Training Grant (Award Number T32HL160529), boosting the USF Health Morsani College of Medicine's capacity to prepare the next generation of scientists in an emerging area of research applicable to many major diseases.

4 Feb 2022

Physical exercise increases synaptic resilience against age-related neuropathologies

Researchers from the UPV/EHU's Department of Pharmacology and the CIBER Mental Health network are taking part in a study published in the latest issue of the prestigious journal Alzheimer's & Dementia; it sheds light on the biological processes that mediate the beneficial effect of physical exercise on cognitive skills and mental health.

3 Feb 2022

Study uncovers a class of microbial enzymes that drive ulcerative colitis

Ulcerative colitis, a subtype of inflammatory bowel disease, is a chronic ailment of the colon affecting nearly one million individuals in the United States. It is thought to be linked to disruptions in the gut microbiome - the bacteria and other microbes that live inside us - but no existing treatments actually target these microorganisms.

2 Feb 2022

TTUHSC project awarded new NIH grant to advance research on amygdala pain mechanisms

It is estimated that more than 100 million U.S. adults are affected by chronic pain, a condition that annually costs the country an estimated $560-635 billion in health care costs, disability and lost productivity.

1 Feb 2022

Phico Therapeutics establishes Scientific Advisory Board

Phico Therapeutics Ltd today announced that it has established a Science Advisory Board (SAB) to provide strategic scientific guidance to the Company.

From Phico Therapeutics 1 Feb 2022

Study reveals potential mechanism for iron accumulation in the aging brain

Breakdowns in regulatory mechanisms cause iron to build up in the brain as organisms grow older, increasing oxidative stress and causing cellular damage, according to a Northwestern Medicine study published in the journal eLife.

31 Jan 2022

Living human breast milk cells offer insight into breast cancer development

Researchers have explored the cellular changes that occur in human mammary tissue in lactating and non-lactating women, offering insight into the relationship between pregnancy, lactation, and breast cancer.

28 Jan 2022

Desipramine and L-cycloserine together reduce ceramide levels in the retina and enhance vision

Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately vision loss.

28 Jan 2022

Unhealthy vaginal microbiome in mothers may contribute to infant deaths and altered development

A new study in mice from University of Maryland School of Medicine researchers showed that an unhealthy vaginal microbiome in pregnant mothers in combination with an unhealthy diet contributed to increased pup deaths and altered development in the surviving babies.

27 Jan 2022

UofL professor wins $6.7 million grant to investigate how metals cause lung cancer

For nearly three decades, John Pierce Wise Sr. has investigated the connection between exposure to metals and cancer, working both in the lab and in the field, reporting significant discoveries about the effects of metals on chromosomes in lung cancer and how those effects differ in humans and in whales.

27 Jan 2022

Pharmacology News and Research

Latest Pharmacology News and Research

Inside the tactical tug of war over the controversial Alzheimer’s drug

Human nose organoids provide better understanding of the first steps toward SARS-CoV-2 infection

Phase one study of oral SARS-CoV-2 antiviral agent nirmatrelvir

Challenges in safely deprescribing common anticholinergic drugs

Biological events occurring during puberty trigger sex differences in learning and memory

Researchers reveal new therapeutic way to block oncogenic RAS mutants

UCI case report: Antihistamines may provide relief for people suffering from long COVID-19 symptoms

Prevalence of genetic susceptibility to cardiac arrhythmia may be underestimated, study says

Paracetamol use increases blood pressure, study shows

Colchicine holds promise to reduce the risk of severe COVID-19

USF receives NIH Training Grant to prepare next generation of translational researchers

Physical exercise increases synaptic resilience against age-related neuropathologies

Study uncovers a class of microbial enzymes that drive ulcerative colitis

TTUHSC project awarded new NIH grant to advance research on amygdala pain mechanisms

Phico Therapeutics establishes Scientific Advisory Board

Study reveals potential mechanism for iron accumulation in the aging brain

Living human breast milk cells offer insight into breast cancer development

Desipramine and L-cycloserine together reduce ceramide levels in the retina and enhance vision

Unhealthy vaginal microbiome in mothers may contribute to infant deaths and altered development

UofL professor wins $6.7 million grant to investigate how metals cause lung cancer

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Pharmacology News and Research

Latest Pharmacology News and Research

Pittcon Highlights: Pharmaceutical & Biologic eBook

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Scalable, Smart, and Accessible: The Future of Lab Automation

Healthy Beginnings, Hopeful Futures: A Conversation with WHO’s Dr. Allotey

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