Sepsis News and Research

Latest Sepsis News and Research

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness compared to patients with bacterial-sepsis and acute respiratory distress syndrome (ARDS). Hence the increase in PAI-1 levels is recognized as an early marker of endothelial dysfunction in COVID-19 patients.

23 May 2021

Risk factors for rare COVID-19 complications in children (MIS-C)

While the earlier waves of COVID-19 relatively spared children, some of the affected children have developed a systemic inflammatory condition, with occasionally fatal outcomes. Called multisystem inflammatory syndrome in children (MIS-C), its pathogenesis and risk factors are the subject of a new study on the medRxiv* preprint server.

21 May 2021

Study validates predictive model for identifying pediatric patients at risk for developing blood clots

Monroe Carell Jr. Children's Hospital at Vanderbilt has launched a study to determine the impact of a predictive model for identifying pediatric patients at risk for developing blood clots or venous thromboembolisms (VTEs).

19 May 2021

Comprehensive blood atlas of COVID-19 identifies hallmarks of disease severity

Researchers in the UK have presented a multi-omics integrated blood atlas that delineates the host immune response in patients with coronavirus disease 2019 (COVID-19) of varying severity, providing a unique reference resource for the interpretation of datasets generated from interventional trials.

13 May 2021

Sepsis can cause alterations in the functioning of defense cells that lead to death

An article published in Frontiers in Immunology suggests that sepsis can cause alterations in the functioning of defense cells that persist even after the patient is discharged from hospital.

12 May 2021

Severe COVID-19 linked to genetic clotting predisposition

Thus, the need to stratify the risk of severe or critical disease in patients presenting with SARS-CoV-2 infection remains a crying necessity. A new preprint research paper posted to the medRxiv server discusses the relationship between severe disease and pre-existing susceptibility to clots and other diseases of the cardiovascular system.

11 May 2021

Unique infectious profile explains why it is so hard to treat COVID-19

A comprehensive review into what we know about COVID-19 and the way it functions suggests the virus has a unique infectious profile, which explains why it can be so hard to treat and why some people experience so-called "long-COVID", struggling with significant health issues months after infection.

7 May 2021

Study uncovers protein 'signature' of severe COVID-19

Researchers at Massachusetts General Hospital have identified the protein "signature" of severe COVID-19, which they describe in a new study published in Cell Reports Medicine.

4 May 2021

COVID-19 in pregnancy does not significantly increase respiratory illness in newborns, says study

A new study published in the journal JAMA offers reassuring evidence that infants born to mothers with coronavirus disease 2019 (COVID-19), or even asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have little increase in respiratory symptoms over babies born to uninfected mothers.

4 May 2021

Developing nanoparticles to detect and kill multi-resistant pathogens

Multi-resistant pathogens are a serious and increasing problem in today's medicine. Where antibiotics are ineffective, these bacteria can cause life-threatening infections.

22 Apr 2021

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

Severe COVID-19 causes sepsis-like manifestations, intense lung injury, and multi-organ failure, all associated with the overproduction of pro-inflammatory cytokines. This "cytokine storm" directly correlates with poor prognosis in this subgroup of patients.

21 Apr 2021

Federal policy to improve outcomes in sepsis patients was mostly ineffective

The first large-scale, multi-hospital evaluation of an "all or none" federal policy intended to improve outcomes in sepsis patients finds that the guidelines are a wash - on average they neither helped nor hurt despite significant investments in their implementation, according to an analysis by University of Pittsburgh School of Medicine clinician-scientists of nearly a dozen hospitals in one academic health system.

20 Apr 2021

Global scarcity of novel antibiotics drives the emergence and spread of antimicrobial resistance

The world is still failing to develop desperately needed antibacterial treatments, despite growing awareness of the urgent threat of antibiotic resistance, according to report by the World Health Organization. WHO reveals that none of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world's most dangerous bacteria.

19 Apr 2021

New plasmonic isothermal PCR technology can detect respiratory viral pathogens in 30 minutes

Researchers in South Korea developed a plasmonic isothermal recombinase polymerase amplification (RPA) array chip, the world's first plasmoinc isothermal PCR technology which can detect 8 types of pathogens (4 bacteria and 4 viruses) that cause acute respiratory infectious diseases in 30 minutes.

15 Apr 2021

INRS professor receives CIHR funding for research on nasopharyngeal bacteria

Professor Frédéric Veyrier of the Institut national de la recherche scientifique has received $711,450 from the Canadian Institutes of Health Research for a project on bacteria of the nasopharynx, including Neisseria.

15 Apr 2021

Medical EdTech specialist, Continulus forms partnership with the Australian Sepsis Network

Continulus has formed a global partnership with the highly regarded Australian Sepsis Network (ASN).

From Continulus 15 Apr 2021

High antibody and inflammatory mediator levels may predict severe COVID-19

A new study reports on biomarkers could help predict the progression of the viral illness to dangerous levels early enough to enable timely intervention.

15 Apr 2021

Leaky gut and microbial dysbiosis could contribute to cytokine storm in severely ill COVID-19 cases

The gut is a well-established route of infection and target for viral damage by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19. This is supported by the clinical observation that about half of COVID-19 patients exhibit gastrointestinal (GI) symptoms.

8 Apr 2021

Chronic cannabis use associated with higher complication rates after spine surgery

For patients undergoing spinal surgery, the diagnosis of cannabis use disorder is associated with higher complication rates, including substantially increased risks of stroke and respiratory complications, reports a study in Spine.

3 Apr 2021

Scientists discover how Streptococcus pyogenes can obtain nutrition from the skin surface

Streptococcus pyogenes is one of the most important bacterial causes of human skin infections. If S. pyogenes invades deep into the tissue, it can cause life-threatening illnesses, such as sepsis and toxic shock.

31 Mar 2021

Sepsis News and Research

Latest Sepsis News and Research

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

Risk factors for rare COVID-19 complications in children (MIS-C)

Study validates predictive model for identifying pediatric patients at risk for developing blood clots

Comprehensive blood atlas of COVID-19 identifies hallmarks of disease severity

Sepsis can cause alterations in the functioning of defense cells that lead to death

Severe COVID-19 linked to genetic clotting predisposition

Unique infectious profile explains why it is so hard to treat COVID-19

Study uncovers protein 'signature' of severe COVID-19

COVID-19 in pregnancy does not significantly increase respiratory illness in newborns, says study

Developing nanoparticles to detect and kill multi-resistant pathogens

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

Federal policy to improve outcomes in sepsis patients was mostly ineffective

Global scarcity of novel antibiotics drives the emergence and spread of antimicrobial resistance

New plasmonic isothermal PCR technology can detect respiratory viral pathogens in 30 minutes

INRS professor receives CIHR funding for research on nasopharyngeal bacteria

Medical EdTech specialist, Continulus forms partnership with the Australian Sepsis Network

High antibody and inflammatory mediator levels may predict severe COVID-19

Leaky gut and microbial dysbiosis could contribute to cytokine storm in severely ill COVID-19 cases

Chronic cannabis use associated with higher complication rates after spine surgery

Scientists discover how Streptococcus pyogenes can obtain nutrition from the skin surface

Innovation in neuroscience drug discovery - eBook eBook

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Scalable, Smart, and Accessible: The Future of Lab Automation

Healthy Beginnings, Hopeful Futures: A Conversation with WHO’s Dr. Allotey

Sepsis News and Research

Latest Sepsis News and Research

Innovation in neuroscience drug discovery - eBook eBook

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Scalable, Smart, and Accessible: The Future of Lab Automation

Healthy Beginnings, Hopeful Futures: A Conversation with WHO’s Dr. Allotey

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