T Cell News and Research

Latest T Cell News and Research

Nucleic acid-hydrolyzing scFv 3D8 exhibits potent antiviral effects on SARS-CoV-2

3D8, a 27-kDa recombinant antibody fragment, was found in autoimmune-prone Murphy Roths Large mice. The single-chain variable fragment (scFv) has the nucleic acid hydrolyzing activity and is shown to degrade DNA or mRNA of viruses in infected cells.

30 Nov 2020

Good cholesterol helps SARS-CoV-2 enter cells

The researchers explained that the SARS-CoV-2 can infect human host cells after its viral spike protein (SARS-2-S) binds to a cellular surface receptor called the angiotensin-converting enzyme 2 (ACE2).

30 Nov 2020

Clonal hematopoiesis linked to severe COVID-19

Now, an international team of researchers from the USA, South Korea and Canada has found that clonal hematopoiesis is tied to the risk of severe COVID-19.

30 Nov 2020

Researchers reveal how SARS-CoV-2 reaches the brain

Using post-mortem tissue samples, a team of researchers from Charité - Universitätsmedizin Berlin have studied the mechanisms by which the novel coronavirus can reach the brains of patients with COVID-19, and how the immune system responds to the virus once it does.

30 Nov 2020

Researchers find way for customized programming of human stem cells

Induced pluripotent stem cells (iPS) have the potential to convert into a wide variety of cell types and tissues for drug testing and cell replacement therapies. However, the "recipes" for this conversion are often complicated and difficult to implement.

30 Nov 2020

Slow moving bacteria colonies can expand quicker than their fast moving counterparts

An international collaboration between researchers at the Niels Bohr Institute, University of Copenhagen, Oxford University, and University of Sheffield has revealed that colonies of slow moving bacteria can expand significantly quicker than their fast moving counterparts.

30 Nov 2020

Memory B cells persist in recovered COVID-19 patients

A team of scientists from the University of Washington, USA, and the Karolinska Institute, Sweden, has comprehensively studied the antibody-mediated immune responses in patients diagnosed with coronavirus disease 2019 (COVID-19).

30 Nov 2020

SARS-CoV-2 immunity in the U.S. remains low

Seroprevalence studies indicate that less than 10% of people in the U. S. have detectable antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from July to September 2020.

30 Nov 2020

Maternal stress may lead to preterm births, accelerate child's biological aging

Why do some people age faster than others? One potential answer, a new UCLA-led study indicates, is that a mother's stress prior to giving birth may accelerate her child's biological aging.

30 Nov 2020

Study outlines a new role for pregnancy-associated plasma protein A in gestational diabetes

Laboratory research and analysis of epidemiological data by Silvia Corvera, MD, and Tiffany Moore Simas, MD, MPH, MEd, and colleagues show that low levels of a protein commonly seen in screening tests for chromosomal disorders during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes mellitus in pregnant women.

30 Nov 2020

Researchers discover molecular mechanism of long-term memory

Researchers at the University of Basel have discovered a molecular mechanism that plays a central role in intact long-term memory. This mechanism is also involved in physiological memory loss in old age.

30 Nov 2020

Virus induced lymphocytes show promise for COVID-19 and future pandemics

Researchers in the United States have conducted a study demonstrating the potential of a novel therapeutic approach to treating coronavirus disease 2019 (COVID-19). The therapy augments the body’s T cell response to the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by providing a boost of rapidly expanded virus-specific T cells.

30 Nov 2020

Highly functional immune response in asymptomatic SARS-CoV-2 infection

Researchers in Singapore have conducted a study showing that asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – mount an efficient, balanced and coordinated cellular immune response that protects the host without appearing to trigger any pathological processes.

30 Nov 2020

Combination therapy found to be effective against treatment-resistant hepatocellular carcinoma

A combination cancer therapy that is effective against treatment-resistant hepatocellular carcinoma (HCC) by inhibiting tumor growth and increasing survival has been identified by researchers at Massachusetts General Hospital.

30 Nov 2020

Penn study opens the door to let CAR T cells reach the tumor microenvironment

The labyrinth of jumbled blood vessels in the tumor microenvironment remains one of the toughest blockades for cellular therapies to penetrate and treat solid tumors.

30 Nov 2020

Mollusc-derived compounds potential medicines for COVID-19 and other respiratory diseases

A research team has reviewed the existing literature on compounds derived from molluscs used for treating respiratory diseases.

30 Nov 2020

Study describes the role of Zmat3 in lymphoma and lung cancer development

A new study from the UPF and WEHI (the Walter and Eliza Hall Institute of Medical Research) in Melbourne, Australia, has described the role of p53 target gene Zmat3 in lymphoma and lung cancer development.

30 Nov 2020

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

A research team from Kumamoto University in Japan has found that the combination of weak pulsed electrical current and heat exerts anti-inflammatory and anti-fibrotic effects in the kidneys, as well as a protective effect against nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells.

30 Nov 2020

Scientists develop novel biomaterial that accelerates bone healing

Scientists have developed a new biomaterial that helps bones heal faster by enhancing adults' stem cell regenerative ability.

30 Nov 2020

Are SARS-CoV-2 protease inhibitors effective antivirals in treating COVID-19?

Many antiviral development studies have focused on the possibility of inhibiting the main viral protease (Mpro), and papain-like protease (PLpro), given their central role in viral replication. A new study draws attention to the high odds that these may not have anti-infective activity because of the redundant pathways present in human host cells.

30 Nov 2020