T Cell News and Research

Latest T Cell News and Research

Can platelet size predict severity and mortality in COVID-19?

The ongoing COVID-19 pandemic has baffled researchers with its propensity to cause symptoms of largely unpredictable severity in the affected individuals. An exciting new study reports on the potential predictive value of platelet size in this situation. COVID-19 patients with severe disease often develop clots in vital organs, which leads to further complications. It is known that platelet size is a good indicator of activation.

22 Jul 2021

Can prior human seasonal coronavirus antibody response patterns predict SARS-CoV-2 inhibition?

A new study, recently released as a preprint on the medRxiv* server, reports the intriguing finding that the cross-neutralizing antibodies elicited by human seasonal coronaviruses (sCoVs) show varying ability to prevent binding between the SARS-CoV-2 spike antigen and its cognate receptor, the angiotensin-converting enzyme 2 (ACE2).

22 Jul 2021

Research provides new insight into uncontrolled inflammation in COVID-19 patients

Research led by Queen Mary University of London provides new insight into the mechanisms that lead to uncontrolled inflammation in COVID-19 patients.

22 Jul 2021

Researchers use nanoparticles as heaters to manipulate the electrical activity of neurons

Nanomaterials have been used in a variety of emerging applications, such as in targeted pharmaceuticals or to bolster other materials and products such as sensors and energy harvesting and storage devices.

22 Jul 2021

Study reveals calcium's role in directing blood flow in the brain

Unlike the rest of the body, there is not enough real estate in the brain for stored energy. Instead, the brain relies on the hundreds of miles of blood vessels within it to supply fresh energy via the blood. Yet, how the brain expresses a need for more energy during increased activity and then directs its blood supply to specific hot spots was, until now, poorly understood.

22 Jul 2021

Emerging SARS-CoV-2 mutations L452R & Y453F evade cellular immunity

The study, published in the journal Cell Host & Microbe, also showed emerging mutations L452R and Y453F in the SARS-CoV-2 spike receptor-binding motif evade (HLA) A24-restricted cellular immunity. Meanwhile, the L452R enhances spike stability, viral fusogenicity, and viral infectivity. Hence, the findings suggest that HLA-restricted cellular immunity potentially affects the evolution of viral phenotypes.

22 Jul 2021

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

The study, published in the journal Angewandte Chemie International Edition, identified many small molecules that bind to certain parts of the SARS-CoV-2 genome that are less likely altered by mutations using dedicated substance libraries. The scientists derived key functional units and groups in ligands for effective and safe targeting of SARS-CoV-2 RNA.

22 Jul 2021

Professional rugby participation may be linked with structural changes in the brain

Participation in elite adult rugby may be associated with changes in brain structure.

22 Jul 2021

Researchers develop a cell culture test to detect substances that harm the placenta and embryo

Researchers at ETH Zurich have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments.

22 Jul 2021

Injecting mice with pulmonary endothelial cells can reverse symptoms of emphysema

Researchers at Weill Cornell Medicine and NewYork-Presbyterian in New York have discovered that injecting mice with pulmonary endothelial cells-the cells that line the walls of blood vessels in the lung-can reverse the symptoms of emphysema.

21 Jul 2021

Oral targeted therapy found to be an effective treatment option for high-risk hairy cell leukemia

The oral targeted therapy drug ibrutinib is an effective treatment option for high-risk hairy cell leukemia, according to a new study conducted by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

21 Jul 2021

Traditional Japanese dish may hold an answer to COVID-19

Natto, a fermented soybean dish often served for breakfast in Japan, originated at the turn of the last millennium but may hold an answer to a modern problem: COVID-19, according to a new study based on cell cultures.

21 Jul 2021

Combination antibody therapies retain potency against SARS-CoV-2 variants, FDA / HHS research

Researchers in the United States have conducted a study showing that while variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can compromise the effectiveness of single therapeutic antibodies at preventing severe coronavirus disease 2019 (COVID-19), many combination antibody products remain potent against the variants.

21 Jul 2021

Existing drug may be effective in treating COVID-19

A new University of Chicago study has found that the drug masitinib may be effective in treating COVID-19.

21 Jul 2021

Scientists seek to block pathogen’s most reliable weapon to cause severe malaria

The parasites that cause severe malaria are well-known for the sinister ways they infect humans, but new research may lead to drugs that could block one of their most reliable weapons: interference with the immune response.

21 Jul 2021

Researchers use information theory to monitor resistance mechanisms to targeted cancer therapy

One of the major challenges in modern cancer therapy is the adaptive response of cancer cells to targeted therapies: initially, these therapies are very often effective, then adaptive resistance occurs, allowing the tumor cells to proliferate again.

21 Jul 2021

Protein involved in cell migration offers clues to cancer metastases

A protein involved in making cells move offers a clue to how certain types of cancer metastasize and develop into secondary tumors, according to new research from the University of Warwick.

21 Jul 2021

Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

Three-dimensional organoid structures grown in the lab allow deeper, almost in situ investigation of a biological system, without the use of living animals. In a paper recently uploaded to the preprint server bioRxiv*, organoids generated from human specimens are utilized to investigate the way in which SARS-CoV-2 interacts with the numerous cells of the intestinal epithelium, finding great heterogeneity in the susceptibility of the organoids and the cells within to infection.

21 Jul 2021

Study examines the host and viral factors that drive SARS-CoV-2 evolution

In a new paper recently uploaded to the preprint server bioRxiv*, two clinical isolates of SARS-CoV-2 are monitored by whole genome sequencing as they are passaged through several generations of Vero cells or human-derived primary nasal epithelial cells (PNEC), allowing direct observation of the occurrence of virus enhancing mutations and the way in which host cell factors shape virus evolution.

21 Jul 2021

Study associates feelings of discrimination and low status with long COVID-19 symptoms

A recent study, released as a preprint on the medRxiv* server, examines the correlation of these symptoms with the patient’s socioeconomic status (SES) and perception of social discrimination, along with other social factors. The researchers found that the first two factors are associated strongly with long-term symptoms of COVID-19.

21 Jul 2021

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T Cell News and Research

Latest T Cell News and Research

Can platelet size predict severity and mortality in COVID-19?

Can prior human seasonal coronavirus antibody response patterns predict SARS-CoV-2 inhibition?

Research provides new insight into uncontrolled inflammation in COVID-19 patients

Researchers use nanoparticles as heaters to manipulate the electrical activity of neurons

Study reveals calcium's role in directing blood flow in the brain

Emerging SARS-CoV-2 mutations L452R & Y453F evade cellular immunity

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

Professional rugby participation may be linked with structural changes in the brain

Researchers develop a cell culture test to detect substances that harm the placenta and embryo

Injecting mice with pulmonary endothelial cells can reverse symptoms of emphysema

Oral targeted therapy found to be an effective treatment option for high-risk hairy cell leukemia

Traditional Japanese dish may hold an answer to COVID-19

Combination antibody therapies retain potency against SARS-CoV-2 variants, FDA / HHS research

Existing drug may be effective in treating COVID-19

Scientists seek to block pathogen’s most reliable weapon to cause severe malaria

Researchers use information theory to monitor resistance mechanisms to targeted cancer therapy

Protein involved in cell migration offers clues to cancer metastases

Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

Study examines the host and viral factors that drive SARS-CoV-2 evolution

Study associates feelings of discrimination and low status with long COVID-19 symptoms

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T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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