In drug development projects, evaluating drug-target residence times can enhance drug efficacy, widen the therapeutic window, and reduce the likelihood of prematurely advancing candidate compounds that may cause adverse effects.
This eBook offers technical insights into the principles and methodologies for applying Transcreener® biochemical assays to measure drug-target residence times, supported by case studies and practical examples.
Key topics covered
- An overview of residence time and its critical role in drug discovery.
- A comparison of various techniques used to determine residence time.
- How the jump-dilution method can be used with Transcreener biochemical assays.
- A breakdown of the data analysis process for accurate residence time determination.
- Case studies showcasing residence time measurements for enzymes such as kinases, phosphodiesterases, and glycosyltransferases.
Download the full eBook now to learn more
About BellBrook Labs
BellBrook Labs is dedicated to providing the pharmaceutical industry with enabling screening tools to accelerate the discovery of more effective therapies. Leveraging its two base platforms, BellBrook has developed assays for hundreds of drug targets.
