Life Science Articles

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The Role of the SCF Complex In The Cell Cycle

SCF complexes are a class of E3 ubiquitination ligase that facilitate proteasomal degradation through the catalysis of ubiquitination.

19 Nov 2018

Ribosome (mRNA) Display: An Overview

Ribosome display is a self-read technology for in vitro selection and evolution of proteins encoded by DNA libraries.

19 Nov 2018

Galectins – An Ancient Family with a Significant Future

Dr. Matthew Blakeley & Prof. Derek Logan, discuss Galectins, sugar-binding proteins, characterised by their binding to a specific carbohydrate, galactoside.

14 Nov 2018

Phage Display Explained

Phage display is a molecular tool used to produce and analyze polypeptides by presenting them on the surface of lysogenic filamentous bacteriophages.

13 Nov 2018

Adipose Tissue-derived Stem Cell (ADSC) Applications

ADSCs have numerous applications in the medical and biomedical science fields, including the treatment of diabetes and the regeneration of tissues.

13 Nov 2018

Using Chromatography to Evaluate the Safety of Food Packaging

Several techniques have been tried and tested for the analysis of food packaging, or food contact materials, but chromatography is the preferred method.

13 Nov 2018

Peptide aptamers are small, artificial polypeptides, which bind to target proteins in a highly specific manner, similar to antibodies. These proteins can occur naturally or they may be artificially created.

1 Nov 2018

Short Hairpin RNA (shRNA) Interference

RNA serves a wide variety of roles within a cell, carrying out catalytic, regulatory, structural and genetic transferal functions. A type of artificial RNA, called short hairpin RNA (shRNA), contains a tight hairpin turn and is frequently used to silence genes in a process called shRNA interference.

1 Nov 2018

High-throughput Screening Using Small Molecule Libraries

Small molecule libraries are often used in drug discovery to find molecules with the greatest activity or inhibitory potential against a particular target.

1 Nov 2018

Hit Selection in High-Throughput Screening

High-throughput screening (HTS) allows scientists to test thousands of samples at once.

1 Nov 2018

Interfering Factors in Assay Design

There are several factors that may affect the sensitivity and reliability of an assay. These must be considered when selecting a signal amplification system.

1 Nov 2018

Fundamentals of Assay Design and Development

This article describes important factors that must be taken into account when designing an assay for the life sciences, including drug development.

1 Nov 2018

How Does Whole Genome Bisulfite Sequencing Work?

Recent advances in sequencing techniques have allowed whole genome sequencing to become more common and quicker. Whole genome bisulfite sequencing (WGBS) is one such next generation sequencing technique that allows users to analyze DNA methylation at single base resolution.

31 Oct 2018