Life Science Articles

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Ion Channel Electrophysiology

Ion channels are imperative to the normal functioning of the cell. The study of ion channels is called electrophysiology, and is described in this article.

23 Oct 2018

Patch Clamp Configurations

The patch clamp technique is used to study ion channel electrophysiology across the cell membrane. There are several configurations, each with pros and cons.

23 Oct 2018

Automated Patch Clamp Techniques

This article describes the applications of automated patch clamp techniques and the benefits of each.

23 Oct 2018

How to Calibrate a pH Meter

A pH meter measures a pH or the acidity/alkalinity of substances. Usually, pH meters need to be calibrated every day or week.

22 Oct 2018

Bacterial Stress Responses

This article describes bacterial stress responses, which boost the survival of bacterium in extreme environmental conditions.

22 Oct 2018

Antibody Purification Techniques

This article describes the techniques used in the purification of monoclonal and polyclonal antibodies from a serum sample.

22 Oct 2018

Pyrosequencing in DNA Methylation Analysis

This article explains pyrosequencing - a sequencing-by-synthesis method which can be applied to measure DNA methylation at CG sites.

18 Oct 2018

Tyramide Signal Amplification (TSA) Applications

Tyramide signal amplification (TSA) is a biological technique used to detect proteins, DNA, and viruses. It can be combined with other techniques such as FISH.

18 Oct 2018

Antimicrobial Properties of Nanoparticles

Nanoparticles are potential broad-spectrum antibiotic agents, and they can overcome evolved resistances to conventional antibiotics. The over-use of regular antibiotics has created ‘superbugs’, bacteria that are resistant to almost all types of antibiotics. Nanoparticles may present a promising solution to this public health hazard.

17 Oct 2018

Silica Nanoparticle Applications in Biomedicine

Silica nanoparticles of between 1 – 100 nm in diameter are cost-effective and simple to produce, with a highly modifiable surface chemistry, shape, and size. They commonly act as a support scaffold or coating for biomolecules or other nanoparticles and potentially make excellent drug delivery platforms due to their highly biocompatible nature and porous structure.

17 Oct 2018

Tyramide Signal Amplification (TSA) Methodology

Tyramide Signal Amplification (TSA) is an immunohistochemistry technique designed to detect and quantify molecules such as proteins and nucleic acids.

17 Oct 2018

Machine Learning in Drug Development

Drug development is an arduous and often fruitless pursuit. Artificial intelligence and machine learning techniques are now being employed to improve efficiency

17 Oct 2018

LUminometric Methylation Assay (LUMA) Pros and Cons

This article describes the principles of the LUminometric Methylation Assay (LUMA) and the pros and cons for researchers looking to use this technique.

17 Oct 2018

Histidine Metabolism

This article explains the biochemical process of histidine metabolism and the role of histidine in the human body.

17 Oct 2018

Superparamagnetism in Biomedicine

Superparamagnetism occurs in ferromagnetic nanoparticles, where in the absence of a magnetic field their total average magnetism in any direction (magnetization) appears to be zero. Once in the presence of an external magnetic field they become magnetized, with their magnetic moments aligning with the field.

17 Oct 2018