Scientists identify bacterial protein VpsT as master regulator in Vibrio

Finding a biological mechanism much like an online social network, scientists have identified the bacterial protein VpsT as the master regulator in Vibrio, the cause of cholera and other enteric diseases. This discovery, now published in the journal Science, provides a major tool to combat enteric disease.

For decades, it has been observed that bacteria engage in biofilm formation in nature and the lab. Like the online social network Facebook, free-swimming bacteria ditch the solitary lifestyle to form a biofilm community, but only after they've signaled their intention to do so to others. The protein VpsT receives the invitation and accepts it by starting a cellular program facilitating the process. "We have the parts list now," said Holger Sondermann, professor at Cornell University's College of Veterinary Medicine. "The next step will be to develop a clear understanding of the triggers and processes that regulate biofilm formation. With this data, we can find opportunities to disrupt the process and find entry points for therapeutic interventions."

Thus, bacteria hunker down with millions of other bacteria to form a biofilm community powerful enough to fog your contacts, rot your teeth, corrode metal and cause a host of human and animal diseases. Biofilms have been implicated in numerous chronic infections including cystic fibrosis, otitis media and prostatitis. Through interactions within a biofilm, the resident population of bacteria is likely to benefit from increased metabolic efficiency, substrate accessibility, enhanced resistance to environmental stress and antibiotics and an increased ability to cause infection and disease, says Sondermann.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Deep learning techniques transform protein structure prediction