Current Alzheimer Research publishes ExonHit's EHT 0202 Phase IIa results

Apr 5 2011

ExonHit Therapeutics (Paris:ALEHT)(Alternext: ALEHT) today announced the publication of Phase IIa results for EHT 0202, its lead candidate for the treatment of Alzheimer's disease, in the journal Current Alzheimer Research. Study data demonstrate good safety and tolerability of EHT 0202 hence supporting its advancement into Phase IIb to assess clinical efficacy and confirm tolerability in a larger cohort of Alzheimer's patients over a longer treatment duration.

"The publication of these promising first patient data in a peer-reviewed Alzheimer's disease journal highlights the interest of the Alzheimer's scientific community in our EHT 0202 compound. Such interest further supports our efforts to pursue the development of EHT 0202 in Phase IIb either through partnering or alternative financing," said Matthew Pando, PhD, Executive Vice President, Therapeutics of ExonHit Therapeutics. "We have also identified several potential biomarkers, including response signatures using our GWSA platform that will strengthen the likelihood of success in future EHT 0202 clinical trials."

Study details

The study was conducted in 23 centers across France under the supervision of Professor Bruno Vellas, Head of the Alzheimer's Disease Clinical Research Center and of the Gérontopôle, Toulouse University Hospital, France. A total of 197 ambulatory patients 60 to 90 years old and suffering from mild to moderate Alzheimer's disease were selected and 159 of them were randomized to receive oral study treatment over a three-month period.

This randomized, double-blind, placebo-controlled study was designed to assess the clinical safety and tolerability, as a primary objective, and also exploratory efficacy of EHT 0202 in patients with Alzheimer's disease. The effect of two different doses of EHT 0202 (either 40 or 80 mg twice a day) as adjunctive therapy to one acetylcholinesterase inhibitor was evaluated in comparison to placebo.