Positive data from Aeterna Zentaris AEZS-131 preclinical study on TNBC

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Dec 11 2011

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Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZ) (the "Company") today announced positive preclinical data in triple-negative breast cancer (TNBC) for its highly selective Erk 1/2 inhibitor anticancer compound, AEZS-131. Data showed that AEZS-131 selectively inhibits Erk at low nanomolar (nM) concentrations and induces G1 arrest. Accordingly, the cytotoxic effect of AEZS-131 was most pronounced in TNBC cell lines with mutations in the MAPK pathway. Data were presented yesterday by Dr. Jörg B. Engel, Medical University of Regensburg, Department of Gynaecology and Obstetrics, Germany, during a poster session at the CTRC - AACR San Antonio Breast Cancer Symposium, in San Antonio, Texas.

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AETERNA ZENTARIS INC.

Posted in: Medical Science News | Medical Condition News | Pharmaceutical News

Tags: B Cell, Bladder Cancer, Breast Cancer, Cancer, Cell, Compound, Gynaecology, Multiple Myeloma, Mutation, Myeloma, Obstetrics, Oncology, Preclinical, T-Cell, Triple Negative Breast Cancer

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