The increase in anal cancer incidence in the U.S. between 1980 and 2005 was greatly influenced by HIV infections in males, but not females, according to a study published October 5 in the Journal of the National Cancer Institute.
Anal cancer in the U.S. is rare, with an estimated 6,230 cases in 2012, but incidence has been steadily increasing in the general population since 1940. HIV infection is significantly associated with an increase in anal cancer risk, and anal cancer is the fourth most common cancer found in HIV-infected people. However, it has been unclear the degree to which anal cancer cases occurring among people with HIV has affected anal cancer incidence in the general population.
In order to determine the impact of HIV on anal cancer incidence in the U.S., Meredith S. Shiels, Ph.D., M.H.S., of the National Cancer Institute and colleagues looked at data from the HIV/AIDS Cancer Match Study-specifically the number of people with anal cancer with and without HIV between 1980 and 2005 in 17 U.S. states and metropolitan areas.
The researchers found that of the 20,533 anal cancer cases between 1980 and 2005, an estimated 1,665 individuals were infected with HIV. In 2001-2005, the most recent time period examined, 1.2% of women with anal cancer and 28.4% of men with anal cancer were HIV-positive. During 1980-2005, HIV infection did not have an impact on the increasing anal cancer incidence rates among women, but HIV had a strong impact on the increasing anal cancer incidence rates among men. "A large proportion of U.S. males with anal cancer in recent years were HIV-infected," the authors write, adding that, "Measures that would effectively prevent anal cancer in HIV-infected males could markedly reduce anal cancer rates at the population level."
Patient-derived organoids: Transforming cancer research and personalized medicine