Clinical data of Trovagene's Precision Cancer Monitoring platform to be presented at two medical conferences

Trovagene, Inc. (NASDAQ: TROV), a developer of cell-free molecular diagnostics, announced today that clinical data featuring its Precision Cancer MonitoringSM platform will be presented at the 2015 Cancer Markers and Liquid Biopsies conference in San Diego, CA on June 11-12, and at the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy in Salt Lake City, UT on June 13-16.

"We continue to advance our clinical programs and present data to the medical community demonstrating the advantages of using our urine-based molecular diagnostics in the management of various cancer types," stated Mark Erlander, Ph.D., chief scientific officer of Trovagene. "The data sets to be presented at these conferences support the clinical utility of our non-invasive cancer monitoring tests in both lung and colorectal cancers, and their ability to empower oncologists to detect and quantitatively track driver mutations to improve treatment decisions."

2015 Cancer Markers and Liquid Biopsies

June 11 2015, 11:25 a.m. PDT Oral Presentation
Early Pharmacodynamics Using Urinary ctDNA as a Putative Biomarker of Drug Response
Presenter: Mark Erlander, Ph.D., Trovagene, Inc.
Highlights: High frequency testing of circulating tumor (ct)DNA mutations in patients receiving molecularly targeted therapies can be used to determine early changes in mutation load brought about by treatment administration, in addition to tumor dynamics when used to monitor treatment response longitudinally

June 12 2015, 10:45 a.m. PDT Oral Presentation
Monitoring Urinary Circulating Tumor DNA (ctDNA) KRAS for Treatment Response in Patients with Metastatic Colorectal Cancer (mCRC)
Collaborator: Afsaneh Barzi, M.D., USC Norris Comprehensive Cancer Center
Highlights: Potential to guide treatment decisions in metastatic colorectal cancer (mCRC) patients based on ctDNA KRAS mutation dynamics

AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy

June 15, 2015, 12:30 – 3:00 p.m. CDT Poster Session
Quantitative Monitoring of EGFR Mutations in Urinary Circulating Tumor DNA Enables Non-Invasive Pharmacodynamic Assessment of Anti-EGFR Drug Response
Single Cell and Circulating Free Nucleic Acid Sequencing Session, Abstract: # 29
Collaborator: Hatim Husain, M.D., UCSD Moores Cancer Center
Highlights:

  • Urine-based EGFR ctDNA assay has been shown to outperform tissue biopsy for the detection of EGFR T790M mutations in metastatic lung cancer patients
  • Non-invasive liquid biopsy enables detection of emerging T790M mutations with greater sensitivity than tissue biopsy, and months before detection of cancer progression with imaging
  • Tracking ctDNA in urine enables determination of response to next generation EGFR T790M inhibitors within days of initial treatment

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Study uncovers why white button mushrooms may help prevent prostate cancer progression