The International Society for Stem Cell Research (ISSCR) today released the ISSCR Standards for Human Stem Cell Use in Research, an international collaboration aimed at enhancing rigor in preclinical research and ultimately strengthening the pipeline of therapies for patients.
This nearly two-year initiative is groundbreaking for the global stem cell research community. The international standards will make a big difference in the quality of science that is performed and published worldwide."
Haifan Lin, President, International Society for Stem Cell Research
The ISSCR is the preeminent international stem cell research society with a reputation for scientific and ethical rigor and has produced field-shaping documents such as the Guidelines for Stem Cell Research and Clinical Translation. The current initiative, which establishes the minimum characterization and reporting criteria for scientists, students, and technicians in basic research laboratories working with human stem cells, is led by an international taskforce of scientists chaired by Tenneille Ludwig, WiCell Research Institute, USA and Peter Andrews, University of Sheffield, UK. The ISSCR's standards for basic and preclinical research draws from previous work to improve the reproducibility of research using pluripotent stem cells, such as that from the International Stem Cell Initiative (ISCI) and the International Stem Cell Banking Initiative (ISBCI), and address tissue stem cells and stem cell-derived model systems with the overall goal of improving reproducibility of experiments from lab to lab and from cell line to cell line.
"The ISSCR Standards represent a huge step forward in articulating Best Practice for use of stem cells in research," said Tenneille Ludwig, co-chair of the taskforce that developed the recommendations. "When adopted, these basic principles will help drive rigor and reproducibility within the laboratory and improve both the quality and rate of science in our field. It was an honor to work with such an experienced, dedicated, passionate group of true stem cell legends to establish this consensus document. The commitment to collaborative effort ultimately resulted in a strong document that will drive the field forward."
One of the most impactful outcomes of the initiative is the development of the "Reporting Practices for Publishing Results with Human Pluripotent and Tissue Stem Cells" checklist. The checklist is intended to help scientists, reviewers, and editors prepare and assess manuscripts for inclusion of critical details relevant to work with pluripotent stem cells (PSCs) and tissue stem cells (TSCs) with the goal of increasing the rigor and reproducibility of research through reporting.
"Stem Cell Reports views these new guidelines as an invaluable aid to authors, journal editors, and reviewers in the stem cell field," said Martin Pera, Editor-in-Chief of Stem Cell Reports. "At our journal, we will be introducing the checklist for authors that accompanies the guidelines on a trial basis soon and soliciting their feedback along with that of reviewers and our Editorial Team. My colleagues and I feel this is a major step forward in ensuring rigor and reproducibility in all areas of stem cell research."
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