Multiplex measurement of low abundance circulating proteins

Simoa SR-X™ empowers scientists to discover, detect, and treat faster and with unmatched sensitivity.

• The Proprietary Simoa® Discs provide single-bead isolation in femto-sized wells and single-molecule identification.
• The SR-X™ is a compact instrument offering built-in touch-screen control and comprehensive data analysis tools.
• Simple 2 or 3-step workflow with nominal user interaction.
• A comprehensive selection of commercial kits is available.
• Simplified development of custom home brew Simoa® assays.
• Multiplexed identification without compromising sensitivity or specificity.

Image Credit: Quanterix

The Simoa® bead-based assay on the SR-X™ enables multiplex measurement of neurodegeneration biomarkers. The distribution of healthy donor sample readings is depicted, along with the LLOQ (dashed lines) of each assay in each validated matrix (see Figure 1).

Image Credit: Quanterix

The value of the SR-X system

The Quanterix SR-X® Ultrasensitive Biomarker Detection System is the latest benchtop instrument powered by Simoa® technology. It offers researchers access to ultra-sensitive protein identification within a compact and affordable system.

The SR-X™ supports multiplexed detection for up to four biomarkers per sample. The low volume requirements increase throughput and productivity and conserve precious samples.

A menu of transferable kits between all bead-based assay instruments is available to researchers. This simplifies the measuring of critical biomarkers with higher sensitivity than standard immunoassay methods and enables the identification of normal and acute biomarker levels with accuracy for a variety of sample types.

1. Initiate the experiment from the home screen. Image Credit: Quanterix

2. Define plate layout. Image Credit: Quanterix

3. Analyze results and generate reports. Image Credit: Quanterix

Quanterix SR-X^® workflow: Simple, scalable, flexible.

1. Add reagents to the assay plate. Image Credit: Quanterix

2. Re-suspend Simoa magnetic beads with automated shaking and incubation. Image Credit: Quanterix

3. Wash beads with automated magnetic separation. Image Credit: Quanterix

4. Load assay plate onto SR-X for single molecule detection on Simoa discs. Image Credit: Quanterix

About Quanterix

From discovery to diagnostics, Quanterix’s ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. Quanterix’s Simoa® technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins that are far lower than the Limit of Quantification (LoQ) of conventional analog methods.

Its industry-leading precision instruments, digital immunoassay technology and CLIA-certified Accelerator laboratory have supported research that advances disease understanding and management in neurology, oncology, immunology, cardiology and infectious disease. Quanterix has been a trusted partner of the scientific community for nearly two decades, powering research published in more than 2,500 peer-reviewed journals.

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