Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

Researchers examined systemic B and T cell responses 16 weeks after BNT162b2 vaccination, and the potency of vaccine-induce neutralizing antibodies, in hemodialysis patients and healthcare workers with no comorbidities.

25 Feb 2022

Study on Omicron related mortality in cancer patients during recent COVID wave

A recent pre-proof study published in the journal Cancer Cell assessed the CFR of cancer patients during the third wave of the coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 Omicron variant.

23 Feb 2022

Merkel cell carcinoma has a higher post-treatment recurrence rate than other skin cancers

Patients treated for Merkel cell carcinoma (MCC) face a five-year recurrence rate of 40%-;markedly higher than the recurrence rates for melanoma and other skin cancers, according to research published today in JAMA Dermatology.

23 Feb 2022

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.

23 Feb 2022

REGEN-COV antibody combination to prevent COVID-19 severity

A new study assessed the effectiveness of REGEN-COV, a combination of casirivimab and imdevimab monoclonal antibodies, in the prevention of COVID-19 disease severity.

22 Feb 2022

Prevalence of chemosensory loss induced by SARS-CoV-2 Omicron variant in Italy

Researchers conducted a prospective cohort study to determine the prevalence of chemosensory dysfunction in mild to moderate COVID-19 patients in Italy.

22 Feb 2022

Drugs that increase fetal hemoglobin levels may help people with sickle cell disease

Sickle cell anemia is an inherited blood disorder where red blood cells become sickle/crescent shaped. It causes frequent infections, swelling in the hands and legs, pain, severe tiredness and delayed growth or puberty.

18 Feb 2022

Study helps understand actionable genetic variation affecting drugs in the Middle East population

A group of researchers at Qatar Foundation have reported the first comprehensive study of the distribution of actionable genetic variation affecting drugs in any Middle Eastern population, with potential implications for preemptive pharmacogenomic implementation in the region.

16 Feb 2022

Children with severe COVID-19 show low mucosal neutralizing activity against SARS-CoV-2

A new study examines neutralizing responses to the ancestral variant of SARS-CoV-2, as well as against later variants of concern.

16 Feb 2022

Real-world data on efficacy and safety of COVID vaccines in Canada

In a recent study posted to the medRxiv* preprint server, researchers evaluated the efficacy and safety of the coronavirus disease 2019 (COVID-19) vaccines in young and elderly cohorts from Canada.

14 Feb 2022

Next era of transplantation is on the horizon, transplant chief says

Satish Nadig, MD, PhD, the Edward G. Elcock Professor of Surgical Research and director of the Comprehensive Transplant Center (CTC), said he arrived at Feinberg in November 2021 with a mission statement: "to have patient-centric impact through quality innovation and education."

8 Feb 2022

Safety and immunogenicity of high-dose quadrivalent influenza vaccine and mRNA-1273 vaccine booster in older adults

A new study has determined the safety and immunogenicity after concomitant administration of QIV-HD and a third dose of the mRNA-1273 vaccine among older adults in the USA

2 Feb 2022

Quantitative framework to investigate the dynamic mechanism of host immune response confronting SARS-CoV-2 infection

The authors highlight that they have created a quantitative framework that allows the dynamic mechanism of the immune response to SARS-CoV-2 to be properly investigated.

2 Feb 2022

Response to COVID-19 vaccine booster in seronegative kidney transplant recipients

Modification of vaccination strategies is needed to improve the immune response to SARS-CoV-2 vaccination in kidney transplant recipients (KTRs).

31 Jan 2022

Combined strategy suppresses the growth of deadly brain tumor

Short bursts of radiation therapy dramatically enhanced the efficiency of targeting glioblastomas with natural nanoparticle-based immunotherapy, thus suppressing growth of the deadly tumor, inducing anti-tumor immunity and prolonging survival in animal models, a research team at Massachusetts General Hospital has discovered.

31 Jan 2022

Study assesses the antibody response to additional dose of COVID-19 vaccine in transplant recipients

A study has begun to assess the antibody response to an additional dose of a COVID-19 mRNA vaccine in kidney and liver transplant recipients, either alone or with a concurrent reduction in immunosuppressive medication.

31 Jan 2022

Study explores factors associated with COVID-19 vaccine hesitancy in individuals with psoriasis

About 40% of people living with psoriasis have had delays to psoriasis treatment and care from the COVID-19 pandemic, according to a new study posted to the medRxiv* server. People of younger age and belonging to an ethnic minority group were more likely to be affected by these disruptions to care.

30 Jan 2022

Immunosuppression News and Research

Further Reading

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

Study on Omicron related mortality in cancer patients during recent COVID wave

Merkel cell carcinoma has a higher post-treatment recurrence rate than other skin cancers

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

REGEN-COV antibody combination to prevent COVID-19 severity

Prevalence of chemosensory loss induced by SARS-CoV-2 Omicron variant in Italy

Drugs that increase fetal hemoglobin levels may help people with sickle cell disease

Study helps understand actionable genetic variation affecting drugs in the Middle East population

Children with severe COVID-19 show low mucosal neutralizing activity against SARS-CoV-2

Real-world data on efficacy and safety of COVID vaccines in Canada

Next era of transplantation is on the horizon, transplant chief says

Safety and immunogenicity of high-dose quadrivalent influenza vaccine and mRNA-1273 vaccine booster in older adults

Quantitative framework to investigate the dynamic mechanism of host immune response confronting SARS-CoV-2 infection

Response to COVID-19 vaccine booster in seronegative kidney transplant recipients

Combined strategy suppresses the growth of deadly brain tumor

Study assesses the antibody response to additional dose of COVID-19 vaccine in transplant recipients

Study explores factors associated with COVID-19 vaccine hesitancy in individuals with psoriasis

Blood proteoforms may help predict liver transplant rejection

Antibodies against SARS-CoV-2 found to persist for up to 15 months after infection

Novel SARS-CoV-2 mutations reported in chronic HIV patients

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