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Nanoparticle COVID-19 vaccine stimulates robust and long lasting immunity in primates

In the study, published on the preprint server bioRxiv, the team evaluated the ability of AS03, CpG 1018 formulated in Alum, the TLR-7 agonist adsorbed to Alum (AS37), the squalene-in-water emulsion (O/W), and Alum to boost protective immunity against SARS-CoV-2.

15 Feb 2021

High-throughput sequencing could allow detection of new SARS-CoV-2 variants in wastewater

A new study reports the use of metagenomics to detect the virus from wastewater samples, indicating community-level circulating variants that are not yet identified or are present in very low proportions on clinical databases.

15 Feb 2021

Researchers study host and viral transcriptomes in tandem to shed light on SARS-CoV-2 infection

In a new study, researchers discuss the use of simultaneous sequencing of both human and viral genes to better understand SARS-CoV-2's infection pathway.

15 Feb 2021

Nanobodies protect against SARS-CoV-2 variants in animal model

Nanobodies are a potential therapeutic strategy for treating COVID-19. While many previous studies report nanobodies active against SARS-CoV-2 in vitro, none have been evaluated via animal models' intranasal administration.

15 Feb 2021

Study: Aspirin should be favored to prevent blood clots in children after complex heart surgery

Aspirin should be favored over warfarin to prevent blood clotting in children who undergo a surgery that replumbs their hearts, according to a new study.

14 Feb 2021

Humidity created inside the face masks may help combat COVID-19

Masks help protect the people wearing them from getting or spreading SARS-CoV-2, the virus that causes COVID-19, but now researchers from the National Institutes of Health have added evidence for yet another potential benefit for wearers: The humidity created inside the mask may help combat respiratory diseases such as COVID-19.

14 Feb 2021

New mouse model of SARS-CoV-2 infection reflects features of human infection

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.

14 Feb 2021

FDA approves drug to reduce frequency of chemotherapy-induced bone marrow suppression

Today, the U.S. Food and Drug Administration approved Cosela (trilaciclib) as the first therapy in its class to reduce the frequency of chemotherapy-induced bone marrow suppression in adults receiving certain types of chemotherapy for extensive-stage (when the cancer has spread beyond the lungs) small cell lung cancer.

13 Feb 2021

Researchers identify protein sequences involved in SARS-CoV-2 infection

In the early days of the COVID-19 pandemic, it was established that SARS-CoV-2 infects cells by binding to the human protein ACE2, which plays a role in regulating blood pressure.

12 Feb 2021

Higher proportion of male children develop COVID-19-related Multisystem Inflammatory Syndrome, finds study

Previous studies about COVID-19 have shown that the illness is often more severe in men than women. However, there is limited data available for the pediatric population. Though children and adolescents are at a lower risk of developing severe illness, some may experience severe symptoms. In some cases, children develop complications, including the multisystem inflammatory syndrome in children (MIS-C). Researchers report that a higher percentage of male children developed MIS-C and died.

11 Feb 2021

Cell-selective nanotherapy can help treat atherosclerotic plaques

Percutaneous coronary intervention (PCI), commonly known as angioplasty with a stent, opens clogged arteries and saves lives. Despite its benefit in treating atherosclerosis that causes coronary artery disease, this common minimally-invasive procedure still poses severe complications for some patients.

11 Feb 2021

Scientists publish new analysis of most diverse genetic data set

Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis today in the journal Nature from genetic sequencing data of more than 53,000 individuals, primarily from minority populations.

10 Feb 2021

Obesity, age and COVID-19 infection can make someone a super-spreader of SARS-CoV-2

Scientists and public health experts have long known that certain individuals, termed "super-spreaders," can transmit COVID-19 with incredible efficiency and devastating consequences.

10 Feb 2021

Chocolate-flavored e-cigarettes are 'particularly harmful' to the lungs, study shows

New research shows chocolate-flavored e-cigarettes are "particularly harmful" to the lungs. In fact, scientists found all 10 flavors tested caused some level of toxicity in the cells lining the lungs, resulting in cell death in some instances.

10 Feb 2021

Lung ultrasound helps predict clinical progression of severe COVID-19 patients

Lung ultrasound, considered a simple method for diagnosing lung disease, can also help predict the clinical progression of severe COVID-19 patients, according to a study conducted at the University of São Paulo's Medical School in São Paulo City, Brazil.

10 Feb 2021

Could Galectin-3 be a potential biomarker to help identify severe COVID-19 early?

Researchers have measured the galectin-3 levels in the sera of hospitalized patients. They found initial high levels indicate patients will become severely ill, suggesting it could be used as a predictor of severe disease.

10 Feb 2021

Orally administered experimental drug halts SARS-CoV-2 replication, prevents infection

Publishing their work in Nature, scientists at the UNC School of Medicine and UNC Gillings School of Global Public Health found that the orally administered experimental drug EIDD-2801 halts SARS-CoV-2 replication and prevents infection of human cells in a new in vivo lab model containing human lung tissue.

10 Feb 2021

Older patients often do not receive optimal therapy for esophageal cancers due to perceived risks

Elderly patients (70 years and over) with locally advanced esophageal (E) and esophagogastric junction (EGJ) cancer (located in the stomach and esophagus) should be considered for optimal therapy that has the potential to cure.

9 Feb 2021

A precursor to remdesivir shows therapeutic potential for COVID-19

A new study points to the potential to use the remdesivir precursor, GS-441524, as a treatment choice for COVID-19.

9 Feb 2021

Study identifies major flaws in iBMEC-based models of the blood-brain barrier

A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center.

9 Feb 2021

Lungs News and Research

Nanoparticle COVID-19 vaccine stimulates robust and long lasting immunity in primates

High-throughput sequencing could allow detection of new SARS-CoV-2 variants in wastewater

Researchers study host and viral transcriptomes in tandem to shed light on SARS-CoV-2 infection

Nanobodies protect against SARS-CoV-2 variants in animal model

Study: Aspirin should be favored to prevent blood clots in children after complex heart surgery

Humidity created inside the face masks may help combat COVID-19

New mouse model of SARS-CoV-2 infection reflects features of human infection

FDA approves drug to reduce frequency of chemotherapy-induced bone marrow suppression

Researchers identify protein sequences involved in SARS-CoV-2 infection

Higher proportion of male children develop COVID-19-related Multisystem Inflammatory Syndrome, finds study

Cell-selective nanotherapy can help treat atherosclerotic plaques

Scientists publish new analysis of most diverse genetic data set

Obesity, age and COVID-19 infection can make someone a super-spreader of SARS-CoV-2

Chocolate-flavored e-cigarettes are 'particularly harmful' to the lungs, study shows

Lung ultrasound helps predict clinical progression of severe COVID-19 patients

Could Galectin-3 be a potential biomarker to help identify severe COVID-19 early?

Orally administered experimental drug halts SARS-CoV-2 replication, prevents infection

Older patients often do not receive optimal therapy for esophageal cancers due to perceived risks

A precursor to remdesivir shows therapeutic potential for COVID-19

Study identifies major flaws in iBMEC-based models of the blood-brain barrier

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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