Pulmonary Artery News and Research

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Genome editing in vascular endothelial cells made possible with a powerful new delivery system

Northwestern Medicine scientists developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which line blood vessel walls.

16 Jan 2022

COVID-19 symptoms found to vary in different immune contexts

In a new study, researchers studied the kinetics of host response to SARS-CoV-2 infection in a Syrian hamster model, tracking disease pathology, viral loads, antibody responses, and inflammatory cytokine production in multiple organs.

11 Jan 2022

Unique nanoparticle can deliver genome editing technology to endothelial cells

The lab of Youyang Zhao, PhD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which are cells that line blood vessel walls.

4 Jan 2022

Thrombosis with thrombocytopenia syndrome rare but serious adverse event associated with Ad26.COV2.S vaccination

A recent study conducted in the United States has revealed that thrombosis with thrombocytopenia syndrome following adenoviral vector-based coronavirus disease 2019 (COVID-19) vaccination is a rare event.

16 Nov 2021

Simple blood test useful for excluding pulmonary embolism among hospitalized COVID-19 patients

A screening blood test originally validated in seriously ill patients without COVID-19 is still clinically useful for ruling out pulmonary embolism in patients hospitalized with the coronavirus, a University of South Florida Health (USF Health) Morsani College of Medicine research team reports.

26 Oct 2021

Hemodynamic-guided management may reduce hospitalizations in patients with earlier stage heart failure

Hemodynamic guided management may reduce heart failure hospitalizations in patients with earlier stage heart failure, according to late breaking research presented in a Hot Line session today at ESC Congress 2021 and published in The Lancet.

27 Aug 2021

New measure of heart function could improve survival for people with heart failure

A new physiological measurement of heart function developed at UVA Health could improve survival for people with heart failure by identifying high-risk patients who require tailored treatments, a new study suggests.

8 Jun 2021

Can SARS-CoV-2’s impairment of endothelium cause vascular disease?

The study, published in the journal Circulation Research, suggests that COVID-19 is not only a respiratory disease but also a vascular disease. It highlights how the virus attacks the vascular system, causing endothelial impairment.

4 May 2021

SARS-CoV-2’s distinctive "spike" protein plays a key role in the disease itself, shows study

Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself.

3 May 2021

FDA approves non-surgical heart valve to treat patients with certain types of congenital heart disease

Today, the U.S. Food and Drug Administration approved the first in the world non-surgical heart valve to treat pediatric and adult patients with a native or surgically-repaired right ventricular outflow tract (RVOT), the part of the heart that carries blood out of the right ventricle to the lungs.

26 Mar 2021

Lab-created heart valves implanted in young lambs can grow with the animal

A groundbreaking new study led by University of Minnesota Twin Cities researchers from both the College of Science and Engineering and the Medical School shows for the first time that lab-created heart valves implanted in young lambs for a year were capable of growth within the recipient.

17 Mar 2021

Early PDA closure may reduce adverse outcomes in premature babies

Extremely low birth weight (ELBW) infants with moderate to large patent ductus arteriosus (PDA) may benefit from transcatheter PDA closure (TCPC) in the first four weeks of life, according to research published by Le Bonheur Cardiologist Ranjit Philip, MD, and Medical Director of Interventional Cardiac Imaging and Interventional Catheterization Laboratory Shyam Sathanandam, MD.

26 Feb 2021

Non-contact IR thermometers fail for COVID-19 temperature screening, say physicians

While a fever is one of the most common symptoms for people who get sick with COVID-19, taking one's temperature is a poor means of screening who is infected with the SARS-CoV-2 virus that causes the disease, and more importantly, who might be contagious.

15 Dec 2020

Authors demonstrate process of misdiagnosis to improve the understanding of congenital heart defect

In a new publication from Cardiovascular Innovations and Applications, Lei Zhang, Tiewei Lv, Xiaoyan Liu, Chuan Feng, Min Zheng, Jie Tian and Huichao Sun from the Children's Hospital of Chongqing Medical University, Chongqing, China and the Chongqing Key Laboratory of Pediatrics, Chongqing, China consider a case of pediatric heart failure caused by the anomalous origin of the left coronary artery from the pulmonary artery.

20 Nov 2020

SARS-CoV-2 spike protein triggers cell signaling pathways in lung vascular cells

A new study published on the preprint server bioRxiv in October 2020 shows that vascular cells in the lung tissue begin to secrete signaling growth factors when exposed to just the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), without the rest of the viral components.

14 Oct 2020

SARS-CoV-2 infection of carotid arteries may explain vascular involvement in COVID-19

A new study published on the preprint server bioRxiv in October 2020 shows that the virus causing COVID-19, namely, SARS-CoV-2, produces replicative infection in the carotid arteries and affects the vascular responses. This could have a profound bearing on the understanding of the disease and its clinical treatment.

14 Oct 2020

A new feasible treatment option for vein of Galen aneurysmal malformation in babies

Endovascular treatment of vein of Galen aneurysmal malformation (VGAM) in babies with severe pulmonary hypertension can improve chances of survival, according to a study released today at the Society of NeuroInterventional Surgery's 17th Annual Meeting.

9 Aug 2020

Study sheds wider light on the clinical profile of patients with pulmonary hypertension

When most people think of high blood pressure, they think of being tested with an arm cuff at a doctor's appointment. That type of blood pressure is separate from pulmonary hypertension (PH), which is high blood pressure in the lung arteries.

28 Jul 2020

Creating the first 3D neural map of a heart

News-Medical spoke to Dr. Vadigepalli and Dr. Schwaber about their groundbreaking research in which they managed to map the neurons in the heart.

15 Jun 2020

No specific COVID-19-linked lesions found despite extensive organ injury

A recent paper published online on the preprint server medRxiv in May 2020 reports autopsy results on COVID-19 patients. The paper concludes that there were no specific hallmark lesions of COVID-19 in any of the many organs found to be injured by the infection in patients who died of the disease.

1 Jun 2020