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New study may shed light on inflammatory bowel disease

Researchers have found an unexpected synergy between a T-cell stimulatory protein -- the ICOS ligand -- and interleukin-10, an immunoregulatory cytokine, to prevent inflammatory bowel disease in mice.

26 Mar 2021

Study: COVID-19 vaccines may remain effective against new influenza viruses

Influenza vaccines need to be evaluated every year to ensure they remain effective against new influenza viruses.

26 Mar 2021

New screening method detects cancer biomarkers more effectively

Early screening can mean the difference between life and death in a cancer and disease diagnosis. That's why University of Central Florida researchers are working to develop a new screening technique that's more than 300 times as effective at detecting a biomarker for diseases like cancer than current methods.

26 Mar 2021

Antibody used for COVID-19 therapy does not inhibit SARS-Cov-2 variants

Cell culture studies show that mutated viruses are less susceptible to inhibition by antibodies from recovered or vaccinated individuals.

26 Mar 2021

Corticotropin-releasing stress hormone may be linked to increased allergic reactions

Increased allergic reactions may be tied to the corticotropin-releasing stress hormone (CRH), suggests a study published this month in the International Journal of Molecular Sciences.

25 Mar 2021

Study shows substantial benefit of combination therapy for advanced Marburg infections

A new study conducted at the Galveston National Laboratory at the The University of Texas Medical Branch at Galveston has shown substantial benefit to combining monoclonal antibodies and the antiviral remdesivir against advanced Marburg virus.

25 Mar 2021

Lupus Research Alliance announces recipients of the 2020 Distinguished Innovator Award

The Lupus Research Alliance proudly announces two exceptional recipients of the 2020 Dr. William E. Paul Distinguished Innovator Award in Lupus and Autoimmunity: Jacques Banchereau, PhD and Ignacio Sanz, MD.

25 Mar 2021

Study observes correlation between COVID-19 mortality and autoantibodies in corticosteroid treated patients

Corticosteroid anti-inflammatory drugs have been applied to COVID-19 patients over the course of the pandemic, though the results are mixed. In a recent study, the outcomes for such patients are collated, demonstrating a striking correlation between the development of autoantibodies and mortality.

25 Mar 2021

Identification of specific anti-SARS-CoV-2 antibodies with cross-neutralization potency

A team of scientists from the USA and Canada recently characterized the cross-neutralizing potency of anti-SARS-CoV-2 antibodies isolated from COVID-19 patients. The findings reveal that some of the isolated antibodies targeting the spike RBD and the S2 subunit are capable of cross-neutralizing other members of the human beta-coronavirus family.

25 Mar 2021

Dual-antigen COVID-19 vaccine elicits humoral and cellular immune responses in mice

The scientific consensus is that safe and highly effective vaccines are required to end the ongoing pandemic of coronavirus disease 2019 COVID-19, caused by SARS-CoV-2. A new study describes a new vaccine that presents two viral antigens to the human immune system, in order to elicit a more efficacious response.

25 Mar 2021

Researchers examine SARS-CoV-2 RNA interactome

A new study focuses on the identification of RNA-binding protein by mass spectrometry (ChIRP-M/S) approach. This study develops a global map that contains the complete set of host proteins that involve the SARS-CoV-2 genome during infection. This study has successfully identified new SARS-CoV-2 host dependency factors by merging proteomics data with gene silencing experiments. Such a discovery has paved new roads to develop more antiviral therapies.

25 Mar 2021

COVID vaccines have only 17% detectable antibodies against SARS-CoV-2 virus

When clinical trials were conducted to determine the immunogenicity -- the ability to elicit an immune response -- for the first two vaccines marshaled against SARS-CoV-2the virus that causes COVID-19, one group was not among those included: people who have received solid organ transplants and others (such as those with autoimmune disorders) who are immunocompromised.

25 Mar 2021

Study finds rapid spread of B.1.1.220 variant with E484K mutation in New York

New research led by Patrick McGann from Walter Reed Army Institute of Research found the first cases of the B.1.1.220 variant with an E484K mutation on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Their results suggest the variant recently emerged as B.1.1.220 was not found in New York before December 2020. Still, it quickly made up 25% of coronavirus strains in late January and early February.

24 Mar 2021

Researchers discover a novel marker of adult human neural stem cells

The mammalian center for learning and memory, hippocampus, has a remarkable capacity to generate new neurons throughout life. Newborn neurons are produced by neural stem cells (NSCs) and they are crucial for forming neural circuits required for learning and memory, and mood control.

24 Mar 2021

Researchers develop innovative biosensor that can detect and quantitate SARS-CoV-2 infection

Researchers have generated protease-activatable fluorescent and luminescent biosensors for SARS-CoV-2 MPro (main protease) and PLPro (papain-like protease) activity, one based on “flip” GFP (FlipGFP), and the other based on circularly permuted firefly luciferase (FFluc).

24 Mar 2021

Modeling study predicts SARS-CoV-2 variants with high receptor binding affinity

A new study adds to the sum of knowledge about SARS-CoV-2, with respect to its natural and biologically significant mutations, using computational modeling of the virus-receptor interactions. Understanding how viral mutations affect the virus-host interactions is crucial for shaping proper strategies to control the virus.

24 Mar 2021

Antibodies News and Research

New study may shed light on inflammatory bowel disease

Study: COVID-19 vaccines may remain effective against new influenza viruses

New screening method detects cancer biomarkers more effectively

Antibody used for COVID-19 therapy does not inhibit SARS-Cov-2 variants

Corticotropin-releasing stress hormone may be linked to increased allergic reactions

Study shows substantial benefit of combination therapy for advanced Marburg infections

Lupus Research Alliance announces recipients of the 2020 Distinguished Innovator Award

Study observes correlation between COVID-19 mortality and autoantibodies in corticosteroid treated patients

Identification of specific anti-SARS-CoV-2 antibodies with cross-neutralization potency

Dual-antigen COVID-19 vaccine elicits humoral and cellular immune responses in mice

Researchers examine SARS-CoV-2 RNA interactome

COVID vaccines have only 17% detectable antibodies against SARS-CoV-2 virus

Study finds rapid spread of B.1.1.220 variant with E484K mutation in New York

Researchers discover a novel marker of adult human neural stem cells

Researchers develop innovative biosensor that can detect and quantitate SARS-CoV-2 infection

Modeling study predicts SARS-CoV-2 variants with high receptor binding affinity

Neutralizing antibodies to SARS-CoV-2 in mice depend on Fc effector function

Detecting SARS-CoV-2 specific IgG antibodies with the Kantaro Covid-SeroKlir Kit

Epitope antibody testing is effective in detecting immune responses to SARS-CoV-2

Glycans play a key role in COVID-19 infection, shows study

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