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Study indicates that certain anti-cancer therapies may hasten cellular aging

New research indicates that certain anti-cancer therapies may hasten cellular aging, where changes in the DNA of patients may contribute to greater inflammation and fatigue.

24 May 2021

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness compared to patients with bacterial-sepsis and acute respiratory distress syndrome (ARDS). Hence the increase in PAI-1 levels is recognized as an early marker of endothelial dysfunction in COVID-19 patients.

23 May 2021

SARS-CoV-2 virus persistence in immunocompromised individuals

Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests are frequently obtained from individuals that have already recovered from the virus in the past. They have therefore undergone seroconversion and bear the expected antibodies.

22 May 2021

Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease

Follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management -- lowering systolic blood pressure to less than 120 mm Hg -- dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering systolic blood pressure to less than 140 mm Hg.

22 May 2021

Risk factors for rare COVID-19 complications in children (MIS-C)

While the earlier waves of COVID-19 relatively spared children, some of the affected children have developed a systemic inflammatory condition, with occasionally fatal outcomes. Called multisystem inflammatory syndrome in children (MIS-C), its pathogenesis and risk factors are the subject of a new study on the medRxiv* preprint server.

21 May 2021

Nearly 1 million more deaths relating to COVID-19 occurred in high-income countries

Almost 1 million extra deaths relating to the covid-19 pandemic occurred in 29 high income countries in 2020, finds a study published by The BMJ today.

21 May 2021

Despite frequent vaccinations, COVID-19 could continue to cause recurrent waves and deaths

Covid-19 could continue to cause recurrent waves and deaths despite frequent vaccinations according to a new study from the University of East Anglia.

21 May 2021

Metal complexes against coronavirus

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 3.42 million deaths worldwide. Despite the fact that there are vaccines for SARS-CoV-2, the emergence of new variants and the lack of adequate treatments have encouraged the search for new ways to combat this disease more effectively.

21 May 2021

Total COVID-19 deaths in US counties have been underestimated by 20%, indicates study

Deaths caused by indirect effects of the pandemic emphasize the need for policy changes that address widening health and racial inequities.

21 May 2021

North America has 87% of all unique SARS-CoV-2 S protein variants in the NCBI database among six continents

Recently, a team of researchers from various countries analyzed the unique variants of S proteins across six continents, including Africa, Asia, Oceania, Europe, South America, and North America. They wanted to characterize the unique S protein variants embedded in SARS-CoV-2 genomes infecting millions of people globally.

20 May 2021

Intranasal COVID-19 therapeutic shows promise in preclinical trials

Researchers from the US and Denmark recently described a novel therapeutic option that targets the SARS-CoV-2 ribonucleic acid (RNA) using locked nucleic acid antisense oligonucleotides (LNA ASOs). They identified an LNA ASO that binds to the 5’ leader sequence of SARS-CoV-2 ORF1a/b. This disrupts a highly conserved stem-loop structure with nanomolar efficacy and inhibits viral replication in host cells.

20 May 2021

Blocking TGFβ1 could improve hematopoiesis in AML patients, indicates study

Bone marrow failure due to acute myeloid leukemia (AML) is a significant factor behind the disease's high rate of morbidity and mortality. Previous studies in mice suggest that AML cells inhibit healthy hematopoietic (blood) stem and progenitor cells (HSPC).

20 May 2021

Mistrust in local, national governments is slowing down child vaccination progress in Africa

Mistrust in local and national governments is slowing down child vaccination progress in Africa, which has half of the world's unvaccinated and undervaccinated children, a study shows.

20 May 2021

Stark racial disparities persist in vaccinations, state-level CDC data shows

Black Americans’ covid-19 vaccination rates are still lagging months into the nation's campaign, while Hispanics are closing the gap and Native Americans show the highest rates overall, according to federal data obtained by KHN.

20 May 2021

Tokyo sees rapid rise of SARS-CoV-2 R.1 lineage

A new research paper posted to the preprint server medRxiv* reports the rise of a new lineage in Tokyo, Japan, bearing a combination of two biologically important mutations.

20 May 2021

Early treatment may prevent clotting in COVID-19 vaccine-related thrombocytopenia

Now, a new report in the Journal of Thrombosis and Hemostasis reveals that timely diagnosis and treatment of this condition may prevent further morbidity and mortality, and enable the vaccine to be used widely with confidence.

20 May 2021

Philly CEAL team receives NIH grant to extend COVID-19 outreach

José A. Bauermeister, PhD, and Antonia M. Villarruel, PhD, are leading one of 10 new research teams from across the country that received National Institutes of Health (NIH) grants totaling $14 million to extend the reach of the NIH's Community Engagement Alliance (CEAL) Against COVID-19 Disparities.

20 May 2021

Monoclonal antibody bamlanivimab reduces hospitalization and death in moderate-to-severe COVID-19

Researchers at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center found that monoclonal antibodies, a COVID-19 treatment administered early after infection, reduce the risk of hospitalization and death by 60 percent in people at high risk of suffering complications from the condition.

20 May 2021

Study confirms that human endocrine system is strongly involved in SARS-Cov-2 infection

The endocrine system is strongly involved in SARS-Cov-2 infection - so much so that evidence of an "endocrine phenotype" of COVID-19 has emerged, according to a statement by the European Society of Endocrinology (ESE) published in the journal Endocrine in April 2021.

20 May 2021

SARS-CoV-2 vaccines from Pfizer-BioNTech and AstraZeneca reduce mortality among the elderly

Researchers in the UK have demonstrated the efficacy of the Pfizer-BioNTech and AstraZeneca vaccines against severe acute respiratory virus coronavirus 2 (SARS-CoV-2) at preventing death among older individuals with coronavirus disease 2019 (COVID-19).

20 May 2021

Mortality News and Research

Study indicates that certain anti-cancer therapies may hasten cellular aging

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

SARS-CoV-2 virus persistence in immunocompromised individuals

Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease

Risk factors for rare COVID-19 complications in children (MIS-C)

Nearly 1 million more deaths relating to COVID-19 occurred in high-income countries

Despite frequent vaccinations, COVID-19 could continue to cause recurrent waves and deaths

Metal complexes against coronavirus

Total COVID-19 deaths in US counties have been underestimated by 20%, indicates study

North America has 87% of all unique SARS-CoV-2 S protein variants in the NCBI database among six continents

Intranasal COVID-19 therapeutic shows promise in preclinical trials

Blocking TGFβ1 could improve hematopoiesis in AML patients, indicates study

Mistrust in local, national governments is slowing down child vaccination progress in Africa

Stark racial disparities persist in vaccinations, state-level CDC data shows

Tokyo sees rapid rise of SARS-CoV-2 R.1 lineage

Early treatment may prevent clotting in COVID-19 vaccine-related thrombocytopenia

Philly CEAL team receives NIH grant to extend COVID-19 outreach

Monoclonal antibody bamlanivimab reduces hospitalization and death in moderate-to-severe COVID-19

Study confirms that human endocrine system is strongly involved in SARS-Cov-2 infection

SARS-CoV-2 vaccines from Pfizer-BioNTech and AstraZeneca reduce mortality among the elderly

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Exploring the G:Box and for high-quality imaging

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