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Study reports potently neutralizing mucosal IgA in saliva of BNT162b2 vaccine recipients

researchers determine the strong neutralizing mucosal component emanating from intramuscular administration of an mRNA vaccine.

21 Feb 2022

SARS-CoV-2 Omicron variant prompts system sciences and precision medicine

In a new review study, researchers aimed to describe the emergence of the Omicron variant, its structure, its impact on health and health systems, and the challenges that can be expected due to this variant.

21 Feb 2022

Comparative transmission study of SARS-CoV-2 Omicron and Delta variant in England

Researchers performed an epidemiological cohort study to assess differences in transmission of the SARS-CoV-2 Omicron and Delta variants in England.

21 Feb 2022

Pathogens in pneumonia-associated respiratory samples from Wuhan prior to SARS-CoV-2 emergence

An interesting paper in PLoS Pathogens describes the broad situation with respect to respiratory pathogens that cause acute respiratory infection (ARI) and pneumonia in the city.

21 Feb 2022

Molecular characteristics of SARS-CoV-2 variants enabling antibody escape

A new review paper published in PLoS Pathogens discusses the new variants and the structural mechanism underlying antibody-mediated neutralization as well as mutational antibody escape.

21 Feb 2022

Mathematical model of host immune response to SARS-CoV-2 demonstrates that age-related risk factors increased viral load

Researchers evaluated the host immune responses to SARS-CoV-2 and its prolonged symptoms.

21 Feb 2022

Study measures recovery rate of SARS-CoV-2-induced olfactory loss

Researchers estimated the trajectory of COVID-19-induced olfactory loss over six months duration and assessed predictive features related to the recovery of olfactory function.

21 Feb 2022

The effect of COVID-19 vaccination on long COVID symptoms

Researchers assessed the effectiveness of COVID-19 vaccines in patients experiencing long COVID.

21 Feb 2022

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Researchers demonstrated the composition and importance of SARS-CoV-2 lipid envelope and assessed the antiviral potential of oral mouthwashes targeting these lipid envelopes.

21 Feb 2022

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

A study posted suggested the inhibition of TBK1 and its homolog KKε could decrease the severity of COVID-19.

21 Feb 2022

Comparing the genomic landscapes of SARS-CoV-2 isolated from animal species relative to that in humans

A recent study identified six candidate mutations in the SARS-CoV-2 genome adaptive to animal hosts.

21 Feb 2022

Biochemical changes in lung physiology not responsible for severe clinical outcomes in the older population

Researchers investigated whether age-dependent changes in lung physiology make the elderly disproportionately susceptible to SARS-CoV-2 infection.

21 Feb 2022

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Researchers examined the detailed mechanisms of ‘cytokine storm’ that induces ARDS, often resulting in the death of severely ill COVID-19 patients.

21 Feb 2022

Emergence of new HIV variant underscores importance of monitoring virus mutations

A new study published in the journal Science reported the presence of a subtype-B variant of HIV-1 with remarkably high virulence, circulating in the Netherlands during the past two decades.

20 Feb 2022

The relative contagiousness of the Alpha, Delta, and Omicron SARS-CoV-2 variants

A new study, available on the arXiv* server, proposes a simple dynamic model for estimating the relative contagiousness of two variants of SARS-CoV-2, namely Alpha and Delta. Furthermore, it demonstrates how to compute the effective reproduction number for a new variant without contemporaneous sequencing results. This is important to assess the state of the pandemic in real-time.

20 Feb 2022

Full schedule of CoronaVac vaccine shown to be highly effective in children

A recent study on vaccine effectiveness showed that a complete primary immunization with CoronaVac effectively protects against severe coronavirus disease 2019 (COVID-19) for children and adolescents between 6 and 16 years of age – consistent with the results from phase 2 clinical trials. The paper is currently available on the Preprints with The Lancet* server while it undergoes peer review.

20 Feb 2022

Syndrome News and Research

Study reports potently neutralizing mucosal IgA in saliva of BNT162b2 vaccine recipients

SARS-CoV-2 Omicron variant prompts system sciences and precision medicine

Comparative transmission study of SARS-CoV-2 Omicron and Delta variant in England

Pathogens in pneumonia-associated respiratory samples from Wuhan prior to SARS-CoV-2 emergence

Molecular characteristics of SARS-CoV-2 variants enabling antibody escape

Mathematical model of host immune response to SARS-CoV-2 demonstrates that age-related risk factors increased viral load

Study measures recovery rate of SARS-CoV-2-induced olfactory loss

The effect of COVID-19 vaccination on long COVID symptoms

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

Comparing the genomic landscapes of SARS-CoV-2 isolated from animal species relative to that in humans

Biochemical changes in lung physiology not responsible for severe clinical outcomes in the older population

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Emergence of new HIV variant underscores importance of monitoring virus mutations

The relative contagiousness of the Alpha, Delta, and Omicron SARS-CoV-2 variants

Full schedule of CoronaVac vaccine shown to be highly effective in children

Benchmarking models of SARS-CoV-2 transmission through aerosols and droplets

Gradual decline in pathogenicity and enhanced cytokine induction in SARS-CoV-2 variants

N-glycosylation blockers reduce SARS-CoV-2 infection

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

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