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3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Three exposures to SARS-CoV-2 spike protein can induce robust neutralizing antibodies against variants

In a new study, scientists revealed that three consecutive exposures SARS-CoV-2 spike protein through infection, vaccination, or both can induce strong neutralizing antibodies against a wide variety of viral variants, including omicron.

31 Jan 2022

How many lives would vaccine sharing have saved?

In a new study, researchers have been investigating different COVID-19 vaccine sharing simulations, and how they would affect affect global mortality.

31 Jan 2022

In California nursing homes, omicron is bad, but so is the isolation

Dina Halperin had been cooped up alone for three weeks in her nursing home room after her two unvaccinated roommates were moved out at the onset of the omicron surge. "I'm frustrated," she said, "and so many of the nursing staff are burned out or just plain tired."

31 Jan 2022

Impact of media dissemination on the use of fluvoxamine against COVID-19

In a new study, researchers examined the changes in the total number of fluvoxamine tablets that were dispensed across retail pharmacies in the U.S.

31 Jan 2022

Evaluating clinical outcomes and viral loads of SARS-CoV-2 Delta and Omicron infections

The current study showed a marked decrease in disease severity with Omicron compared to the Delta variant.

31 Jan 2022

Estimating the impending endemic seasonality of SARS-CoV-2 in global population centers

A new study uses long-term data on the incidence of circulating coronaviruses and estimates the endemic seasonality of SARS-CoV-2 in global population centers.

31 Jan 2022

Nucleocapsid antigen found to be a sensitive biomarker for acute COVID-19 infection

In a new study, researchers found that nucleocapsid antigen in the blood (antigenemia) is a sensitive and specific biomarker for acute coronavirus disease 2019 infection.

31 Jan 2022

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Scientists have recently detected and analyzed viral PrDs in the S protein of SARS-CoV-2, which are the novel regulators of virion assembly.

31 Jan 2022

Protection provided to children through parental vaccination with the BNT162b2 vaccine

In a new study published in Science, scientists estimated the protection provided to children by means of parental vaccination with the BNT162b2 vaccine.

31 Jan 2022

Patient-reported impact of having surgery delayed during the COVID-19 pandemic

Researchers recently published a study to address this knowledge gap and understand the scope of the personal impact on patients and their daily lives due to delayed surgeries.

31 Jan 2022

Vaccine hypersensitivity in children

A new paper published in Pediatric Allergy and Immunity provides a useful overview of such reactions in relation to pediatric vaccines.

31 Jan 2022

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

Patients undergoing neurosurgical operations with concomitant COVID-19 infection have higher rates of perioperative complications

This unique paper compares neurosurgical patients with COVID-19 for perioperative complications to those without COVID-19.

31 Jan 2022

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

A team of scientists from the United States has recently defined the substrate envelop of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study is currently available on the bioRxiv* preprint server while awaiting peer review.

31 Jan 2022

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A new study by Norwegian researchers suggests that vaccine-induced immunological memory and the activation of recall responses in the body yields similar coverage for Omicron and Delta variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

31 Jan 2022

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Minks may be a suitable animal model for testing severe COVID-19 infections, finds a recent bioRxiv* preprint study. While mice and ferrets are used in preclinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is currently no model specific to severe disease.

30 Jan 2022

Study explores factors associated with COVID-19 vaccine hesitancy in individuals with psoriasis

About 40% of people living with psoriasis have had delays to psoriasis treatment and care from the COVID-19 pandemic, according to a new study posted to the medRxiv* server. People of younger age and belonging to an ethnic minority group were more likely to be affected by these disruptions to care.

30 Jan 2022

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

A recent study assesses the neutralization efficacy of the mRNA-1273 vaccine against the SARS-CoV-2 Omicron variant in children, adolescents, and adults.

30 Jan 2022

Study shows homologous COVID boosters better than heterologous in most kidney transplant recipients

Researchers screen kidney transplant recipients to evaluate their serological responses following immunization with three doses of the COVID-19 vaccine.

30 Jan 2022

Syndrome News and Research

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Three exposures to SARS-CoV-2 spike protein can induce robust neutralizing antibodies against variants

How many lives would vaccine sharing have saved?

In California nursing homes, omicron is bad, but so is the isolation

Impact of media dissemination on the use of fluvoxamine against COVID-19

Evaluating clinical outcomes and viral loads of SARS-CoV-2 Delta and Omicron infections

Estimating the impending endemic seasonality of SARS-CoV-2 in global population centers

Nucleocapsid antigen found to be a sensitive biomarker for acute COVID-19 infection

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Protection provided to children through parental vaccination with the BNT162b2 vaccine

Patient-reported impact of having surgery delayed during the COVID-19 pandemic

Vaccine hypersensitivity in children

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

Patients undergoing neurosurgical operations with concomitant COVID-19 infection have higher rates of perioperative complications

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Study explores factors associated with COVID-19 vaccine hesitancy in individuals with psoriasis

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

Study shows homologous COVID boosters better than heterologous in most kidney transplant recipients

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