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Immune responses against SARS-CoV-2 Delta variant after BNT162b2 vaccination in people living with HIV

Researchers from Sorbonne Universite have been investigating the effect of the BNT162b2 mRNA vaccine on HIV-positive individuals.

9 Dec 2021

Increased risk of COVID-19 breakthrough infections in fully vaccinated people with HIV

New study results showed a 41% greater incidence of breakthrough infections in people with HIV compared to that of people without HIV.

9 Dec 2021

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

New study results provide evidence that the binding between SARS-CoV-2 RBD and host ACE2 receptor is aided by the glycosylation on each protein.

9 Dec 2021

Potential association between senescence and aging in COVID-19

A review published in Cells discussed characteristics of cellular senescence and its potential role in COVID-19.

9 Dec 2021

Immunogenicity and safety of COVID-19 subunit vaccine Nanocovax in animal models

Researchers have developed Nanocovax, a COVID-19 subunit vaccine based on recombinant protein technology to produce the extracellular (soluble) portion of the S protein of SARS-CoV-2.

9 Dec 2021

Positive results from Phase 3 study of Medicago’s plant-based COVID-19 vaccine candidate announced

Medicago, a biopharmaceutical company headquartered in Quebec City, and GlaxoSmithKline today announce positive efficacy and safety results from the global Phase 3 placebo-controlled efficacy study of Medicago’s plant-based COVID-19 vaccine candidate in combination with GSK’s pandemic adjuvant, conducted in over 24,000 subjects, adults 18 years and above, across six countries.

9 Dec 2021

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

The N-terminal domain has a fold that can bind sugar, and new research led by Jonathan Lees from Oxford Brookes University found the sugar-binding pockets near the N-terminal domain help to increase viral infectivity. Furthermore, the findings show that the SARS-CoV-2 sugar-binding pockets are evolving with added loops observed in the pockets of new variants.

9 Dec 2021

Mass-spectrometry and PCR testing identifies various targets related to SARS-CoV-2 VOCs

New research posted to the medRxiv* preprint server suggests that the Agena MassARRAY SARS-CoV-2 Panel PCR test effectively detects a variety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

9 Dec 2021

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Continued replication of severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) under selective pressure from natural and vaccine-induced immunity has led to the emergence of variants of concern (VOCs) with increased transmissibility or virulence.

8 Dec 2021

For most young people, COVID vaccine-related myocarditis is not serious

A new study published in the journal Circulation aimed to describe a large case series of suspected myocarditis temporally related with the COVID-19 vaccine in adolescents and young adults below 21 years of age across the United States and Canada.

8 Dec 2021

Neutralization antibodies elevated in nursing home residents after COVID-19 mRNA boosters

Researchers from the United States, in their recent study published on the preprint server medRxiv*, have evaluated the humoral responses to third vaccine dose in nursing home residents and healthcare workers (HCW) and found that that second booster (or third vaccine dose) significantly increased anti-spike, anti-receptor binding domain (RBD), and neutralization titers in almost all nursing home residents and HCW to considerably higher levels than what was attained after the completion of the initial two-dose vaccine series.

8 Dec 2021

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

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8 Dec 2021

Researchers identify a molecular culprit for COVID-19's seasonal nature

Not to pile on, but winter is coming and the COVID-19 pandemic is about to get worse. Not necessarily because of omicron – scientists are still working that one out – but because there’s more evidence than ever that COVID-19 is a seasonal disease.

8 Dec 2021

Internal tremors and vibrations symptoms among people with long-COVID

In a recent study, researchers aimed to identify a potentially important cluster of similar patient-reported symptoms from PASC-affected individuals.

8 Dec 2021

Study shows SARS-CoV-2 transmission in Ireland before first official COVID-19 report

New study findings showed evidence of SARS-CoV-2 dissemination in Ireland prior to the identification of the first official COVID-19 case.

8 Dec 2021

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

In a new study, scientists have computationally predicted the structure of the Omicron spike RBD from available sequences and explored the dynamics of antigen-antibody interactions.

8 Dec 2021

Characterization of the baseline SARS-CoV-2 S-reactive B cell repertoire

Researchers from the University Of Amsterdam have identified several oddities in unvaccinated individuals' antibody response to the spike protein.

8 Dec 2021

Study identifies ORF8 protein as a key COVID-19 causing factor

New study suggests that the SARS-CoV-2 ORF8 protein is the underlying cause behind severe COVID-19 infection.

8 Dec 2021

SARS-CoV-2 antibody profiles in vaccinated and convalescent macaques compared to humans

New findings suggest that Macaque monkeys may not be the ideal model when testing for SARS-CoV-2.

8 Dec 2021

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

A team of researchers set out to build a full-length, membrane-embedded spike to study its conformational dynamics at the atomic level using molecular dynamics simulations to understand better how this important component of the virus machinery works.

8 Dec 2021

SARS News and Research

Immune responses against SARS-CoV-2 Delta variant after BNT162b2 vaccination in people living with HIV

Increased risk of COVID-19 breakthrough infections in fully vaccinated people with HIV

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

Potential association between senescence and aging in COVID-19

Immunogenicity and safety of COVID-19 subunit vaccine Nanocovax in animal models

Positive results from Phase 3 study of Medicago’s plant-based COVID-19 vaccine candidate announced

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

Mass-spectrometry and PCR testing identifies various targets related to SARS-CoV-2 VOCs

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

For most young people, COVID vaccine-related myocarditis is not serious

Neutralization antibodies elevated in nursing home residents after COVID-19 mRNA boosters

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

Researchers identify a molecular culprit for COVID-19's seasonal nature

Internal tremors and vibrations symptoms among people with long-COVID

Study shows SARS-CoV-2 transmission in Ireland before first official COVID-19 report

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

Characterization of the baseline SARS-CoV-2 S-reactive B cell repertoire

Study identifies ORF8 protein as a key COVID-19 causing factor

SARS-CoV-2 antibody profiles in vaccinated and convalescent macaques compared to humans

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

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