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COVID-19 has increased the urgency of advanced care planning, WVU study shows

No one likes to think about their own mortality. But COVID-19 has shoved life's dark questions to the forefront: "What if I'm hooked to a ventilator and can't speak?" "If my heart stops beating, do I want to be resuscitated?" "Where do I want to die?"

19 Oct 2020

Melatonin may increase survival chances among intubated COVID-19 patients

Researchers at Columbia University in New York have conducted a study showing that patients with coronavirus disease 2019 (COVID-19) who require intubation and mechanical ventilation due to respiratory distress may benefit from treatment with the hormone melatonin.

19 Oct 2020

Temple researchers identify criteria to predict cytokine storm in COVID-19 patients

Like a cold front that moves in, setting the stage for severe weather, coronavirus infection triggers showers of infection-fighting immune molecules - showers that sometimes escalate into a chaotic immune response known as a cytokine storm.

19 Oct 2020

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

As the COVID-19 pandemic progresses with little prospect of immediate relief, a recent study by Johns Hopkins University researchers published on the preprint server medRxiv* in October 2020 discusses the association of Immunoglobulin M (IgM) autoantibodies against the host receptor that binds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with severe disease via vascular endothelial damage. This could help develop better therapies and prognostic criteria.

19 Oct 2020

Study: Sea lions have largest negative impact on early-arriving endangered Chinook salmon

The Columbia River is home to one of the West Coast's most important Chinook salmon runs. Through late spring and early summer, mature fish return from the sea and begin their arduous journey upriver to spawn.

19 Oct 2020

WHO study finds Remdesivir and other repurposed drugs ineffective in COVID-19

A large-scale randomized trial has recently been conducted by the World Health Organization (WHO) to evaluate the efficacy of four repurposed antiviral medicines, including Remdesivir, Hydroxychloroquine, Lopinavir, and Interferon, currently used to treat hospitalized coronavirus disease 2019 (COVID-19) patients.

18 Oct 2020

Obesity changes ACE2 and TMPRSS2 expression in mice: Implications for COVID-19

Researchers studying young obese mice found that expression of ACE2, a receptor in host cells that binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is higher in the lungs and trachea of obese mice. The finding could partly explain why obesity is a high-risk factor for COVID-19.

18 Oct 2020

Study examines how international travel restrictions have affected COVID-19 mortality

Travel restrictions implemented early on in the pandemic have been crucial in slowing the spread of the coronavirus and keeping death rates low.

16 Oct 2020

Plant genetic engineering to sustainably address micronutrient malnutrition

More than two billion people worldwide suffer from micronutrient malnutrition due to deficiencies in minerals and vitamins.

16 Oct 2020

NIH launches adaptive Phase 3 clinical trial to test immune modulator drugs in COVID-19 patients

The National Institutes of Health has launched an adaptive Phase 3 clinical trial to evaluate the safety and efficacy of three immune modulator drugs in hospitalized adults with COVID-19.

16 Oct 2020

Control trial proves effectiveness of repurposed drugs for COVID-19 treatment

In just six months, the world's largest randomized control trial on COVID-19 therapeutics has generated conclusive evidence on the effectiveness of repurposed drugs for the treatment of COVID-19.

16 Oct 2020

Researchers develop new tool to improve the effectiveness of liver cancer outreach

October is liver cancer awareness month, which aims to educate those who are high risk about the importance of semiannual screenings.

16 Oct 2020

Impact of COVID-19 on Australians with hypertension

Ten months into the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is unclear how people with hypertension are coping, given their increased risk. A retrospective case-control study compared people with hypertension to matched healthy controls during COVID-19 lockdown to determine whether they have higher risk perceptions, anxiety, and prevention intentions. The study is published on the preprint server medRxiv* in October 2020.

16 Oct 2020

MITHRAS trial investigates superiority of TMVR-induced iASD over medical therapy

The MITHRAS randomized clinical trial found that interventional closure of an iatrogenic atrial septal defect (iASD) driven by transcatheter mitral valve repair (TMVR) was not superior to conservative medical treatment with regard to the primary endpoint of change in six-minute walking distance.

16 Oct 2020

REFLECT II clinical trial evaluates safety and efficacy of cerebral embolic deflection filter

The REFLECT II randomized clinical trial evaluating the safety and efficacy of a device designed to reduce cerebral embolization and ischemic stroke, complications of transcatheter aortic valve replacement (TAVR), found that the device met the primary safety endpoint compared to historical controls but did not demonstrate superiority of the device for the primary hierarchical efficacy endpoint.

16 Oct 2020

New self-expanding bioprosthetic valve used in TAVR fails to demonstrate non-inferiority

In a randomized clinical trial, SCOPE II, a new self-expanding bioprosthetic valve used in transcatheter aortic valve replacement (TAVR) failed to demonstrate non-inferiority compared to an existing self-expanding valve.

16 Oct 2020

Bariatric surgery associated with longer life expectancy

People who have undergone obesity (bariatric) surgery live three years longer, on average, than those given conventional treatment for their obesity, a University of Gothenburg study shows. Compared with the general population, however, both groups' excess mortality is high.

15 Oct 2020

Mendelian randomization helps evaluate impact of circulating proteins in COVID-19

Researchers identify circulating proteins influencing COVID-19 susceptibility and severity by employing a large-scale two-sample Mendelian randomization (MR) study.

15 Oct 2020

Blood purification outside the body in COVID-19 patients

Rodney Rosalia et al., in a recent medRxiv preprint research paper, study the longitudinal variation of parameters involved with systemic inflammation in critically ill COVID-19 patients upon EBP treatment.

15 Oct 2020

Common kidney tests can help estimate risk of cardiovascular disease

Taking into account two common kidney disease tests may greatly enhance doctors' abilities to estimate patients' cardiovascular disease risks, enabling millions of patients to have better preventive cardiovascular care, according to a large international study co-led by researchers at the Johns Hopkins Bloomberg School of Public Health.

15 Oct 2020

Mortality News and Research

COVID-19 has increased the urgency of advanced care planning, WVU study shows

Melatonin may increase survival chances among intubated COVID-19 patients

Temple researchers identify criteria to predict cytokine storm in COVID-19 patients

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

Study: Sea lions have largest negative impact on early-arriving endangered Chinook salmon

WHO study finds Remdesivir and other repurposed drugs ineffective in COVID-19

Obesity changes ACE2 and TMPRSS2 expression in mice: Implications for COVID-19

Study examines how international travel restrictions have affected COVID-19 mortality

Plant genetic engineering to sustainably address micronutrient malnutrition

NIH launches adaptive Phase 3 clinical trial to test immune modulator drugs in COVID-19 patients

Control trial proves effectiveness of repurposed drugs for COVID-19 treatment

Researchers develop new tool to improve the effectiveness of liver cancer outreach

Impact of COVID-19 on Australians with hypertension

MITHRAS trial investigates superiority of TMVR-induced iASD over medical therapy

REFLECT II clinical trial evaluates safety and efficacy of cerebral embolic deflection filter

New self-expanding bioprosthetic valve used in TAVR fails to demonstrate non-inferiority

Bariatric surgery associated with longer life expectancy

Mendelian randomization helps evaluate impact of circulating proteins in COVID-19

Blood purification outside the body in COVID-19 patients

Common kidney tests can help estimate risk of cardiovascular disease

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Exploring the G:Box and for high-quality imaging

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