SARS CoV 2 News and Research

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Study shows SARS-CoV-2 cell receptor is a novel target of the gamma-secretase enzyme complex

Based on structural similarities with other targets of the gamma-secretase system, researchers from Columbia University Irving Medical Center in the United States show that the SARS-CoV-2 receptor for cell entry may be affected by its proteolytic activity. Their results are currently freely available in a bioRxiv preprint paper.

6 Sep 2020

Antibody responses against seasonal common cold coronaviruses may protect against SARS-CoV-2

With the use of an accurate high throughput assay, researchers from the Weizmann Institute of Science and Magen David Adom Blood Services in Israel showed substantial inter-individual variability and antibody cross-reactivity against seasonal coronaviruses upon SARS-CoV-2 infection, with important implications for immune surveys and vaccines. The study is currently available on the medRxiv* preprint server.

6 Sep 2020

Monitoring the activity of unconventional T cells could predict COVID-19 severity

Researchers in France have discovered that patients suffering from severe COVID-19 show changes in a class of immune cells known as unconventional T cells.

5 Sep 2020

MIS-C linked to COVID-19 damages children's hearts

Multisystem inflammatory syndrome in children (MIS-C), believed to be linked to COVID-19, damages the heart to such an extent that some children will need lifelong monitoring and interventions, said the senior author of a medical literature review published Sept. 4 in EClinicalMedicine, a journal of The Lancet.

5 Sep 2020

Early-phase Russian trials reveal safety and immunogenicity of two formulations of a two-part vaccine

Results from two early-phase Russian non-randomised vaccine trials (Sputnik V) in a total of 76 people are published today in The Lancet, finding that two formulations of a two-part vaccine have a good safety profile with no serious adverse events detected over 42 days, and induce antibody responses in all participants within 21 days.

5 Sep 2020

Study: Small neutralizing antibody can block SARS-CoV-2 from entering human cells

Researchers at Karolinska Institutet in Sweden have identified a small neutralizing antibody, a so-called nanobody, that has the capacity to block SARS-CoV-2 from entering human cells.

4 Sep 2020

Spike-based priming leads to high neutralizing activity in animal models

A new report by researchers at the University of Melbourne and published on the preprint server bioRxiv in September 2020 reports on the use of a two-protein two-dose vaccine regimen and its immunogenicity in two animal models.

4 Sep 2020

D614G spike mutation increases infectivity of SARS-CoV-2 and neutralization susceptibility

As the COVID-19 pandemic progresses, it is crucial to track the viral changes in order to link the clinical and epidemiological features of the disease with these mutations. A new study published on the preprint server bioRxiv* in September 2020 reports on a common severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutation, D614G, and its effects on the virus.

4 Sep 2020

Heightened COVID-19 risk among pregnant women

Since the emergence of the coronavirus disease (COVID-19) pandemic, little is known about the risks of COVID-19 to pregnant women. Now, a new study reveals that pregnant women with COVID-19 are less likely to experience symptoms of fever and myalgia than non-pregnant women of reproductive age, but maybe at a heightened risk of being admitted to intensive care.

3 Sep 2020

Research compares T cell responses to SARS-CoV-2 and influenza

As the COVID-19 pandemic continues to grow, scientists are focusing on understanding how the host immune system responds to the virus in order to better shape public health responses and develop effective vaccines. A new study published on the preprint server medRxiv in September 2020 reports the T cell memory response to the SARS-CoV-2 spike protein, recombinant nucleocapsid protein, and other pooled peptides derived from convalescent patients.

3 Sep 2020

Individual biocontainment unit protects health care workers against aerosolized SARS-CoV-2 virus

Especially in settings where personal protective equipment, or PPE, is in short supply, intubation -- inserting a breathing tube down a patient's throat -- poses a major risk of SARS-CoV-2 exposure for doctors and nurses as viral particles are released into the air.

3 Sep 2020

Simulation platform teaches students the fundamentals of responses to pandemics

In 2015, a team of specialists in modeling disease outbreaks got together with educators to create Operation Outbreak, an educational platform and simulation intended to teach high school and college students the fundamentals of responses to pandemics.

3 Sep 2020

Novel fabric mask for enhanced protection and comfort

Imagine a reusable face mask that protects wearers and those around them from SARS-CoV-2, is comfortable enough to wear all day, and stays in place without frequent adjustment.

3 Sep 2020

Study shows fatty liver disease is a significant risk factor for COVID-19 hospitalization

A recent observational study by US researchers reveals that individuals with non-alcoholic fatty liver disease and steatohepatitis have increased odds of hospitalization due to coronavirus disease (COVID-19); conversely, metabolic surgery was found to be protective against the admission of infected individuals. The study is currently available on the medRxiv* preprint server.

3 Sep 2020

Research provides a map of coronavirus entry factors across the human body

An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases and Cornell University in the US have investigated cellular factors that could be significant for an infection.

3 Sep 2020

Understanding SARS-CoV-2 evolution requires more focus on structural variants

Researchers in the United States and Canada warn that more attention needs to be paid to the role that structural variants and recombination in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have played in the evolutionary history of the virus.

3 Sep 2020

SARS CoV 2 News and Research

Study shows SARS-CoV-2 cell receptor is a novel target of the gamma-secretase enzyme complex

Antibody responses against seasonal common cold coronaviruses may protect against SARS-CoV-2

Monitoring the activity of unconventional T cells could predict COVID-19 severity

MIS-C linked to COVID-19 damages children's hearts

Early-phase Russian trials reveal safety and immunogenicity of two formulations of a two-part vaccine

Study: Small neutralizing antibody can block SARS-CoV-2 from entering human cells

Spike-based priming leads to high neutralizing activity in animal models

D614G spike mutation increases infectivity of SARS-CoV-2 and neutralization susceptibility

Heightened COVID-19 risk among pregnant women

Research compares T cell responses to SARS-CoV-2 and influenza

Individual biocontainment unit protects health care workers against aerosolized SARS-CoV-2 virus

Simulation platform teaches students the fundamentals of responses to pandemics

Novel fabric mask for enhanced protection and comfort

Study shows fatty liver disease is a significant risk factor for COVID-19 hospitalization

Research provides a map of coronavirus entry factors across the human body

Understanding SARS-CoV-2 evolution requires more focus on structural variants

Underlying pathology of MIS-C in children following SARS-CoV-2 infection

New biocontainment unit could help healthcare workers caring for COVID-19 patients

COVID-19 vaccine candidate protects animals against SARS-CoV-2

Chest X-rays found to be highly predictive of COVID-19

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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