Biochemistry

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A new method to produce complex natural products in amoebae

A research team at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute in Jena, Germany has developed a new method to produce complex natural products in amoebae.

4 Mar 2022

Researchers design a peptide hydrogel for cell spheroids production

This study is led by Prof. Zhimou Yang and Prof. Quan Chen (College of Life Sciences in Nankai University), and Prof. Jianfeng Liu (Institute of Radiation Medicine, Chinese Academy of Medical Sciences). Prof. Zhimou Yang, who is working in the research field of peptide self-assembly biomaterials for more than 15 years, designed the peptide hydrogel for cell spheroids production.

4 Mar 2022

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

A high-fat diet is not enough to cause short-term fatty liver disease. However, if this diet is combined with the intake of beverages sweetened with liquid fructose, the accumulation of fats in the liver accelerates and hypertriglyceridemia —a cardiovascular risk factor— can appear.

4 Mar 2022

Texas A&M team continues research on the potential cure for Menkes disease

A life-saving cure solution for Menkes Disease, a copper deficiency in young children, is at the center of a licensing agreement by the The Texas A&M University System, through the Intellectual Property and Commercialization office of Texas A&M AgriLife Research, and a California-based biopharmaceutical company, Engrail Therapeutics.

3 Mar 2022

Lipidomic profiling may provide early prediction of type 2 diabetes and cardiovascular disease risk

Simultaneous measurement of dozens of types of fats in the blood ("lipidomics") can predict the risk of developing type 2 diabetes (T2D) and cardiovascular disease (CVD) years in the future, according to a new study publishing March 3rd in the open-access journal PLOS Biology from Chris Lauber of Lipotype, Germany, and colleagues.

3 Mar 2022

Research uncovers a new molecular interaction mechanism for SARS-CoV2

The virus causing the current COVID-19 pandemic is the SARS-CoV-2. Soon after the pandemic outbreak in 2019, the ACE-2 protein, which is present on some of our cells´ surface, was identified as the receptor facilitating host cell viral entry.

3 Mar 2022

Sugar-decorated proteins in mucus could prevent SARS-CoV-2 viruses from spreading from surfaces

Early in the pandemic, many people fastidiously disinfected surfaces because laboratory studies predicted that SARS-CoV-2 could be easily transmitted in this way.

2 Mar 2022

Australian bull ants' venom component exploits a pain pathway in mammals

Australian bull ants have evolved a venom molecule perfectly tuned to target one of their predators – the echidna – that also could have implications for people with long-term pain, University of Queensland researchers say.

2 Mar 2022

New type of drug delivery vehicle mimics the properties of a red blood cell

From the liver to the kidneys to the lungs, the human body is equipped with many levels of filters, which protect the body from harmful outside materials. But this system also has its downsides. Critically important drugs such as chemotherapy or multiple sclerosis treatments are also foreign materials, so the body filters out a large portion of these drugs – up to 90%, in some cases.

2 Mar 2022

Research sheds light on the role of lipids in Alzheimer’s disease development

Neurons in the brain coexist with and rely on many other cell types to function properly. Astrocytes, which take their name from their star shape, ensure the survival of neurons by feeding and detoxifying them with the help of a multifunctional protein, APOE.

1 Mar 2022

Metabolites could be used as biomarkers for forensic diagnosis of diabetes mellitus

Determining the cause of death is one of the most crucial and challenging parts of a forensic investigation.

28 Feb 2022

MIT chemists develop a novel way to synthesize himastatin

Chemists at MIT have developed a novel way to synthesize himastatin, a natural compound that has shown potential as an antibiotic.

24 Feb 2022

Study provides a promising new avenue for development of anti-obesity treatments

An anti-tumor drug promotes weight loss in mice at low doses by activating a natural hunger-suppressing pathway, according to a new study publishing February 24th in the open-access journal PLOS Biology by Jiang Wei Wu and colleagues at Northwest A&F University in Shaanxi, China.

24 Feb 2022

Scientists reveal the possibility to improve immunological memory in vaccines

A key transcription factor in T-cell immunology is crucial to the immune system's "memory" in recognizing threats it has already faced before – and it may be possible to improve this immunological memory in vaccines, according to a new paper by scientists at the Hackensack Meridian Center for Discovery and Innovation.

24 Feb 2022

Researchers show how the biological system can be steered with artificial organic neurons

For the first time, researchers demonstrate an artificial organic neuron, a nerve cell, that can be integrated with a living plant and an artificial organic synapse.

23 Feb 2022

Why is it Important to Democratize Proteomics Data?

In this interview, we speak to Steve Kosteski from IsoPlexis about the importance of single-cell proteomics within the life sciences sector.

From Society for Laboratory Automation and Screening (SLAS) 23 Feb 2022

Accelerating genomics research with the firefly

In this interview, we speak to Paul Lomax from SPT Labtech about their new firefly platform and how it will help to accelerate genomics research.

From SPT Labtech 23 Feb 2022

New approach for extensive screening of monoclonal antibody clones against multiple myeloma cells

Multiple myeloma (MM) is a largely incurable cancer of plasma cells with an extremely poor prognosis. However, investigators from Japan have recently found that a common component of amino acid transporters, CD98 heavy chain, represents an effective monoclonal antibody target in treating MM.

22 Feb 2022

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

21 Feb 2022

Insight into cellular waste disposal could lead to new treatments for neurodegenerative diseases

A 'waste collection' tidies up our cells. If something does not go according to plan, serious diseases such as Alzheimer's or Parkinson's may develop.

20 Feb 2022

Biochemistry

A new method to produce complex natural products in amoebae

Researchers design a peptide hydrogel for cell spheroids production

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

Texas A&M team continues research on the potential cure for Menkes disease

Lipidomic profiling may provide early prediction of type 2 diabetes and cardiovascular disease risk

Research uncovers a new molecular interaction mechanism for SARS-CoV2

Sugar-decorated proteins in mucus could prevent SARS-CoV-2 viruses from spreading from surfaces

Australian bull ants' venom component exploits a pain pathway in mammals

New type of drug delivery vehicle mimics the properties of a red blood cell

Research sheds light on the role of lipids in Alzheimer’s disease development

Metabolites could be used as biomarkers for forensic diagnosis of diabetes mellitus

MIT chemists develop a novel way to synthesize himastatin

Study provides a promising new avenue for development of anti-obesity treatments

Scientists reveal the possibility to improve immunological memory in vaccines

Researchers show how the biological system can be steered with artificial organic neurons

Why is it Important to Democratize Proteomics Data?

Accelerating genomics research with the firefly

New approach for extensive screening of monoclonal antibody clones against multiple myeloma cells

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Insight into cellular waste disposal could lead to new treatments for neurodegenerative diseases

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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