Disease/Infection News

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Attenuated virulence and protective immunity in SARS-CoV-2 with a mutation in the S1/S2 cleavage site

A new study published in mBio investigates the impact of the furin cleavage site on viral growth and pathogenesis.

31 Aug 2021

Development of SARS-CoV-2 antibody escape variants in an immunocompromised individual

A new study published in mBio discusses the microevolution of SARS-CoV-2.

31 Aug 2021

Does SARS-CoV-2 infection protect against reinfection?

A new review showed that the protective effect of prior SARS-CoV-2 infection is at least equivalent to that of vaccination.

31 Aug 2021

Anti-SARS-CoV-2 immunity induced by Pfizer/BioNTech vaccine may decline after 6 months

A team of scientists from Israel has recently claimed that antiviral immunity induced by the mRNA-based coronavirus disease 2019 (COVID-19) BNT162b2 gradually declines over time, highlighting the need for a third booster dose.

31 Aug 2021

mRNA COVID-19 vaccines induce high antibody titers with significant neutralizing potency in saliva

Scientists from the USA and Canada have recently demonstrated that the dynamics of antibody response induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 (COVID-19) vaccines are different.

31 Aug 2021

Post-infection vaccination produces potent neutralizing antibodies against SARS-CoV-2 variants

The best protection against new SARS-CoV-2 infections or reinfections may be obtained by a combination of vaccine-elicited and infection-induced antibodies.

31 Aug 2021

Investigational vaccine does not provide sufficient protection against HIV infection

An investigational HIV vaccine tested in the "Imbokodo" clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data. The Phase 2b proof-of-concept study, which began in November 2017, enrolled 2,637 women ages 18 to 35 years from five countries.

31 Aug 2021

J&J COVID-19 booster shot produces robust antibody response

The study showed neutralizing antibody responses produced by the Johnson & Johnson–Janssen vaccine was robust and stable eight months after immunization.

31 Aug 2021

Coronavirus buildup in the lungs is likely behind high mortality rates

A buildup of coronavirus in the lungs is likely behind the steep mortality rates seen in the pandemic, a new study finds.

31 Aug 2021

Study compares risk of hospitalization from SARS-CoV-2 delta and alpha variants

Largest study to date analyzing more than 40,000 COVID-19 cases (including a combination of vaccinated and unvaccinated individuals) confirmed by virus genome sequencing finds a two-fold increased risk of hospitalization from delta versus alpha variant infections.

31 Aug 2021

Delta cutting ‘like a buzzsaw’ through Oregon-California border counties

If you live in one of the rural communities tucked into the forested hillsides along the Oregon-California border and need serious medical care, you'll probably wind up at Asante Rogue Regional Medical Center. It serves about nine counties on either side of the border.

31 Aug 2021

The tale of mRNA vaccines: Turning calamity into opportunity

In a review paper published in the journal Nature Reviews, researchers from Carnegie Mellon University and the University of Pennsylvania have described the underlying technologies for mRNA vaccines and their future prospects with improved delivery systems and applications in diseases beyond the ongoing COVID-19 pandemic.

31 Aug 2021

Severe COVID-19 negatively impacts kidney function in kidney transplant recipients

During her medical school career, third-year student Skylar Nahi has taken advantage of the mentorship and research opportunities available to Feinberg students.

31 Aug 2021

Study uses novel statistical approaches to identify factors that contributed to COVID-19 mortality

Staying home and limiting local travel, supporting access to primary care, and limiting contacts in contagion hubs -; including hospitals, schools, and workplaces -; are strategies that might help reduce COVID-19-related deaths, according to new research. The research team, by statisticians at Penn State, the Sant'Anna School of Advanced Studies in Pisa, Italy, and Université Laval in Quebec, Canada, used novel statistical approaches to compare the first wave of the epidemic across 20 regions in Italy and identify factors that contributed to mortality.

31 Aug 2021

Durability of cellular immune memory to SARS-CoV-2 after mRNA vaccination

A recent study, available on the bioRxiv* preprint server, investigated the durability of cellular immune memory after mRNA vaccination against SARS-CoV-2 and whether booster jabs affect the durability of different immune response components. The study included testing for antibodies and cellular immune responses in covid patients and recovered individuals.

31 Aug 2021

SARS-CoV-2 animal origin: What we know so far

Scientists at the University of Glasgow Centre for Virus Research in the United Kingdom and the South China Agricultural University in Guangzhou, China, have shed light on the animal origin of SARS-CoV-2, tracing back to the first outbreak of the severe acute respiratory syndrome coronavirus (SARS-CoV), the infectious agent of the severe acute respiratory syndrome (SARS) in China in 2002 to 2003.

31 Aug 2021

New evidence provides strong support for the halt on prescribing hydroxychloroquine for COVID-19

In 2021, in the United States alone, there have been more than 560,000 prescriptions of hydroxychloroquine for the prevention, post-exposure and treatment of COVID-19.

31 Aug 2021

Monoclonal antibody treatment combo can reduce the impact of COVID-19 in high-risk patients

In an observational study, Mayo Clinic researchers report that the combination of casirivimab and imdevimab - two monoclonal antibody treatments under Food and Drug Administration emergency use authorization - keep high-risk patients out of the hospital when infected with mild to moderate COVID-19. The findings appear in The Lancet's EClinicalMedicine.

31 Aug 2021

Scientists identify potential biomarkers to predict COVID-19 outcomes

A team of scientists from the United States has recently examined the trajectory of early immune biomarkers in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. They have identified specific plasma proteins that can accurately predict the clinical and virological outcomes in SARS-CoV-2 infected patients. The study is currently available on the medRxiv* preprint server.

31 Aug 2021

Vaccinated individuals with breakthrough SARS-CoV-2 infection have much lower risk of hospitalization

A recent study conducted by a team of US-based scientists has revealed that unvaccinated individuals are 17-times more likely to be hospitalized due to severe coronavirus disease 2019 (COVID-19) compared to those vaccinated against the disease. The study is currently available on the medRxiv* preprint server.

31 Aug 2021

Disease/Infection News

Attenuated virulence and protective immunity in SARS-CoV-2 with a mutation in the S1/S2 cleavage site

Development of SARS-CoV-2 antibody escape variants in an immunocompromised individual

Does SARS-CoV-2 infection protect against reinfection?

Anti-SARS-CoV-2 immunity induced by Pfizer/BioNTech vaccine may decline after 6 months

mRNA COVID-19 vaccines induce high antibody titers with significant neutralizing potency in saliva

Post-infection vaccination produces potent neutralizing antibodies against SARS-CoV-2 variants

Investigational vaccine does not provide sufficient protection against HIV infection

J&J COVID-19 booster shot produces robust antibody response

Coronavirus buildup in the lungs is likely behind high mortality rates

Study compares risk of hospitalization from SARS-CoV-2 delta and alpha variants

Delta cutting ‘like a buzzsaw’ through Oregon-California border counties

The tale of mRNA vaccines: Turning calamity into opportunity

Severe COVID-19 negatively impacts kidney function in kidney transplant recipients

Study uses novel statistical approaches to identify factors that contributed to COVID-19 mortality

Durability of cellular immune memory to SARS-CoV-2 after mRNA vaccination

SARS-CoV-2 animal origin: What we know so far

New evidence provides strong support for the halt on prescribing hydroxychloroquine for COVID-19

Monoclonal antibody treatment combo can reduce the impact of COVID-19 in high-risk patients

Scientists identify potential biomarkers to predict COVID-19 outcomes

Vaccinated individuals with breakthrough SARS-CoV-2 infection have much lower risk of hospitalization

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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