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Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Self-amplifying RNA (saRNA) is an advanced platform for nucleic acid vaccine development. The backbone is typically derived from an alphaviral genome and encodes a gene of interest (GOI) and a viral replicase that can amplify the genomic and subgenomic RNA.

30 Aug 2021

Large Israeli study offers detailed look at safety profile of mRNA vaccine against SARS-CoV-2

A deep look into a nationwide mass vaccination setting in Israel revealed that the BNT162b2 (Pfizer–BioNTech) vaccine is not linked with an elevated risk of a majority of the adverse events under study, with the exception of myocarditis. However, even that potentially severe adverse event is much more pervasive following the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), found a new study published in the New England Journal of Medicine (NEJM).

30 Aug 2021

Next-gen COVID vaccine to make persistent neutralizing antibodies

Presently, there is a need to develop improved versions of COVID-19 vaccines that are effective against the SARS-CoV-2 variants of concern (VOC) and can confer long-term protection. Considering the need of the hour, scientists from the University of Sydney in Australia have generated a new COVID-19 vaccine CoVac-II and evaluated its effect against COVID-19 strains. The findings from this study are published on the bioRxiv* preprint server while awaiting peer review.

30 Aug 2021

Can molecular mimicry impact fertility in female COVID-19 patients?

There exists a possibility that COVID-19 can also affect the reproductive function in the body, which can lead to infertility in infected patients. A study published in the American Journal of Reproductive Immunology explored the impact of SARS-CoV-2 infection on reproductive functions and fertility.

30 Aug 2021

Modeling of COVID-19 seroprevalence and resurgence in Canada

Despite increased vaccine distribution and a significant decrease in the number of COVID-19 cases in Canada, the future of the pandemic is still a major concern, based on the possibility of a resurgence in the short term as well as long term and an understanding of the future of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. It is not clear if the Canadian population will reach herd immunity or if there is a risk of future resurgence of the virus in the Fall or Winter.

30 Aug 2021

COVID-19 in Virginia: Beliefs drive behavior

A new paper examines this phenomenon as it relates to the state of Virginia to outline lessons to be learned from this debacle of pandemic management.

29 Aug 2021

Have SARS-CoV-2 symptoms changed in the UK population over time?

A new paper compares changes in the symptoms due to COVID-19 over the course of the pandemic.

29 Aug 2021

What might the third wave of COVID-19 in India look like?

A new study applies mathematical modeling to understand what the third wave of the pandemic might look like in India.

29 Aug 2021

Assessing the risks of thrombotic events post vaccination with ChAdOx1 and BNT162b2 vaccines in England

Researchers aim to better understand the population-level thrombotic risks post COVID-19 vaccination with both the ChAdOx1-S and BNT162b2 vaccines.

29 Aug 2021

Researchers analyze dynamic changes in chest CT images over 167 days in 11 COVID-19 patients

Announcing a new article publication for Zoonoses journal. In this article the authors Jianqin Liang, Guizeng Liu, Shuzhuang Yu, Yang Yang, Yanchun Li, Hongli Tian, Zhe Chen and Wenping Gong The Eighth Medical Center of PLA General Hospital, Beijing, China and Nanpi County People's Hospital, Hebei, China discuss dynamic changes in chest CT images over 167 days in 11 patients with COVID-19.

28 Aug 2021

Study reveals measures to tackle musical COVID-19 transmission

As the COVID-19 pandemic swept the globe in 2020, musicians around the world were desperate for the answers to two pressing questions: Can playing musical instruments transmit COVID-19? And if so, what can be done?

28 Aug 2021

Scientists analyze the impact of two strategies in stopping COVID-19 pandemic

How can we best organise on-site workplace and school attendance periods and remote work to slow the circulation of Sars-CoV-2? Is it better to separate classes? Bring your whole team in at the same time? Set this up on daily or weekly schedules?

28 Aug 2021

Northwestern researchers continue investigation on all aspects of COVID-19 pandemic

Northwestern Medicine scientists continue to investigate all aspects of the COVID-19 pandemic: from molecular mechanisms of infection, to child hospitalization and single-dose vaccine response.

28 Aug 2021

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

The National Institutes of Health has begun a clinical trial to assess the antibody response to an extra dose of an authorized or approved COVID-19 vaccine in people with autoimmune disease who did not respond to an original COVID-19 vaccine regimen.

27 Aug 2021

Additional COVID-19 support deployed to the South West of England

From Friday 27 August additional support will be deployed to some local authorities in the South West of England.

27 Aug 2021

SARS-CoV-2 destabilizes host RNA to improve fitness

In a study recently published in the journal Nature Communications, scientists have mapped the interactions between SARS-CoV-2 RNA and host RNA. They have observed that the virus heavily methylates its genome using the methylation machinery of the host RNA, leading to an improvement in viral fitness.

27 Aug 2021

Recognizing viral genomes in quick, ‘CRISP’ ways

Researchers from China recently reviewed the latest advancements, applications, and prospects of virus detection using CRISPR-Cas systems.

27 Aug 2021

MS patients on anti-CD20 therapy have robust T cell responses to SARS-CoV-2 vaccination

Scientists have observed that MS patients exhibit a robust T cell response despite a reduced humoral response to COVID-19 vaccines. Read more here.

27 Aug 2021

The negative impact of the COVID-19 pandemic on adult mental health in the UK

A review of the literature on the impact of COVID-19 on adult mental health in the UK has revealed a decline in mental health. Read more here.

27 Aug 2021

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

The AIDS Clinical Trials Group, the largest global HIV research network, which has expanded its focus to include evaluating outpatient treatment for COVID-19, today announced positive data for the monoclonal antibody combination therapy BRII-196/BRII-198 from the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies.

27 Aug 2021

Disease/Infection News

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Large Israeli study offers detailed look at safety profile of mRNA vaccine against SARS-CoV-2

Next-gen COVID vaccine to make persistent neutralizing antibodies

Can molecular mimicry impact fertility in female COVID-19 patients?

Modeling of COVID-19 seroprevalence and resurgence in Canada

COVID-19 in Virginia: Beliefs drive behavior

Have SARS-CoV-2 symptoms changed in the UK population over time?

What might the third wave of COVID-19 in India look like?

Assessing the risks of thrombotic events post vaccination with ChAdOx1 and BNT162b2 vaccines in England

Researchers analyze dynamic changes in chest CT images over 167 days in 11 COVID-19 patients

Study reveals measures to tackle musical COVID-19 transmission

Scientists analyze the impact of two strategies in stopping COVID-19 pandemic

Northwestern researchers continue investigation on all aspects of COVID-19 pandemic

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

Additional COVID-19 support deployed to the South West of England

SARS-CoV-2 destabilizes host RNA to improve fitness

Recognizing viral genomes in quick, ‘CRISP’ ways

MS patients on anti-CD20 therapy have robust T cell responses to SARS-CoV-2 vaccination

The negative impact of the COVID-19 pandemic on adult mental health in the UK

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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