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New clinical trial to examine the safety of dapivirine vaginal ring and PrEP in pregnant women

The first clinical trial specifically designed to test the safety of the monthly dapivirine vaginal ring in pregnant women has begun in southern and eastern Africa.

10 Feb 2020

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

An international clinical trial evaluating whether two investigational drugs can slow memory loss and cognitive decline in people in the early stages of a rare, inherited form of Alzheimer's disease has yielded disappointing results, an initial analysis of the data has shown.

10 Feb 2020

Common drug could mitigate risk of 'a broken heart' during bereavement

The increased risk of heart attack or "a broken heart" in early bereavement could be reduced by using common medication in a novel way, according to a world-first study led by the University of Sydney and funded by Heart Research Australia.

10 Feb 2020

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

According to results from a Phase I/IIa trial at The University of Texas MD Anderson Cancer Center, treatment with cord blood-derived chimeric antigen receptor natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin's lymphoma and chronic lymphocytic leukemia, with no major toxicities observed.

6 Feb 2020

Hendra antibody trial shows promise in a world-first human clinical trial

The Hendra virus is a potent pathogen transmitted to humans from animals that cause a severe and often fatal illness in both infected horses and humans. Originating from fruit bats, the virus caused an outbreak in Australia in 1994.

4 Feb 2020

Promising HIV vaccine fails in a large-scale clinical trial

The human immune deficiency virus (HIV) is an infectious disease that can lead to immunosuppression called acquired immunodeficiency syndrome (AIDS). For decades, scientists race to discover a vaccine that can help prevent the spread of the virus. The latest trial testing a new experimental vaccine in South Africa end in disappointment after deeming ineffective in preventing infection.

4 Feb 2020

Investigational HIV vaccine not effective in preventing HIV

The National Institute of Allergy and Infectious Diseases), part of the National Institutes of Health, has stopped administration of vaccinations in its HVTN 702 clinical trial of an investigational HIV vaccine.

3 Feb 2020

FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy

Calibr, the drug discovery and development division of Scripps Research, today announced that the U.S. Food and Drug Administration has given clearance to the Investigational New Drug (IND) application for Calibr's "switchable" CAR-T cell therapy, which is being evaluated for the treatment of certain cancers, including relapsed/refractory B-cell malignancies such as non-Hodgkin lymphoma and chronic lymphocytic leukemia.

3 Feb 2020

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

American and British teams led by Drs Kohn (University of California, Los Angeles), Malech (NIH), Williams (Boston Children's) and Trasher (Great Ormond Street Institute of Child Health) published yesterday in Nature Medicine the conclusive results of a gene therapy trial conducted in the United States and Great Britain in 9 patients with X-linked Chronic Septic Granulomatosis (X-CGD), a rare and severe immune dysfunction. Six of them are free of treatment for complications generated by the disease.

28 Jan 2020

Zinc acetate lozenges did not reduce duration of common cold in randomized trial

Administration of zinc acetate lozenges to common cold patients did not shorten colds in a randomized trial published in BMJ Open.

28 Jan 2020

Clinical trial to test safety, effectiveness of mAb against malaria in healthy volunteers

A Phase 1 clinical trial testing the safety and effectiveness of a monoclonal antibody (mAb) against malaria has begun enrolling healthy adult volunteers at the National Institutes of Health Clinical Center in Bethesda, Maryland. The trial, sponsored by NIH's National Institute of Allergy and Infectious Diseases (NIAID), is the first to test mAb CIS43LS in humans. It aims to enroll up to 73 volunteers aged 18 through 50 years old who have never had malaria.

27 Jan 2020

Daratumumab proves effective in patients with relapsed AL amyloidosis

There's a new treatment option available for patients with AL amyloidosis: daratumumab. Studied in a prospective clinical trial, only one of the two clinical trials of this agent in AL amyloidosis worldwide, researchers have found this anti-cancer drug to be well tolerated and effective in patients with relapsed AL amyloidosis when used with appropriate pre- and post-infusion medications.

27 Jan 2020

FDA approves new drug that could aid MS diagnoses for clinical trials

A new drug that could make it easier for doctors to diagnose multiple sclerosis in its earlier stages has been approved for its first human trials by the U.S. Food and Drug Administration.

27 Jan 2020

First glioblastoma patient treated with genetically modified poliovirus at UH

University Hospitals Seidman Cancer Center treated its first patient in a new clinical trial to validate the groundbreaking effects of the poliovirus on glioblastoma, a deadly Grade IV cancer of the brain.

24 Jan 2020

GW expands clinical trial of neoadjuvant immunotherapy for high-risk cutaneous squamous cell carcinoma

The Cutaneous Oncology Program at the George Washington University (GW) Cancer Center was selected as the first global site for a clinical trial for patients with high-risk cutaneous squamous cell carcinoma.

22 Jan 2020

Taking high dose of vitamin D linked lower blood pressure in overweight children

Overweight and obese vitamin D-deficient children who took a relatively high dose of vitamin D every day for six months had lower blood pressure and improved insulin sensitivity than their peers who took a lower dose, according to the results of a UPMC Children's Hospital of Pittsburgh clinical trial reported in The American Journal of Clinical Nutrition.

21 Jan 2020

Lab tests reveal that newly discovered T-cell can kill various types of cancer

Scientists have discovered a T-cell receptor that has proven effective in targeting a variety of cancers in mice and in human cells within the lab.

21 Jan 2020

Patient enrollment in potentially life-extending clinical trials is low

Patient enrollment in clinical trials as the first course of treatment after cancer diagnosis is low, despite the fact that enrollment may increase life expectancy, according to researchers at Penn State.

20 Jan 2020

First randomized clinical trial compares targeted therapies for acute lymphoblastic leukemia

Researchers from St. Jude Children's Research Hospital and the Chinese Children's Cancer Group led the first randomized, Phase III clinical trial comparing targeted therapies for acute lymphoblastic leukemia (ALL) driven by the Philadelphia chromosome.

17 Jan 2020

UK-wide trial aims to find treatments that can slow or reverse MND

Hundreds of people living with motor neurone disease are being invited to take part in one of the UK's most comprehensive clinical trials in a generation.

16 Jan 2020

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Drug Trial News

New clinical trial to examine the safety of dapivirine vaginal ring and PrEP in pregnant women

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

Common drug could mitigate risk of 'a broken heart' during bereavement

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

Hendra antibody trial shows promise in a world-first human clinical trial

Promising HIV vaccine fails in a large-scale clinical trial

Investigational HIV vaccine not effective in preventing HIV

FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

Zinc acetate lozenges did not reduce duration of common cold in randomized trial

Clinical trial to test safety, effectiveness of mAb against malaria in healthy volunteers

Daratumumab proves effective in patients with relapsed AL amyloidosis

FDA approves new drug that could aid MS diagnoses for clinical trials

First glioblastoma patient treated with genetically modified poliovirus at UH

GW expands clinical trial of neoadjuvant immunotherapy for high-risk cutaneous squamous cell carcinoma

Taking high dose of vitamin D linked lower blood pressure in overweight children

Lab tests reveal that newly discovered T-cell can kill various types of cancer

Patient enrollment in potentially life-extending clinical trials is low

First randomized clinical trial compares targeted therapies for acute lymphoblastic leukemia

UK-wide trial aims to find treatments that can slow or reverse MND

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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