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First randomized clinical trial compares targeted therapies for acute lymphoblastic leukemia

Researchers from St. Jude Children's Research Hospital and the Chinese Children's Cancer Group led the first randomized, Phase III clinical trial comparing targeted therapies for acute lymphoblastic leukemia (ALL) driven by the Philadelphia chromosome.

17 Jan 2020

UK-wide trial aims to find treatments that can slow or reverse MND

Hundreds of people living with motor neurone disease are being invited to take part in one of the UK's most comprehensive clinical trials in a generation.

16 Jan 2020

Flash Radiotherapy could Deliver all the Radiation Needed in One Rapid Treatment

Researchers at the University of Pennsylvania have demonstrated that a new approach to delivering radiation could one day mean that cancer patients will be able to receive their entire course of radiotherapy within less than a second as opposed to several weeks.

10 Jan 2020

Siah2 Gene Control could Help Treat Melanomas More Effectively

To develop improved cancer immunotherapies, it is essential to understand how cancers shut down the natural immune response to foreign antigens. This current study demonstrates how mice lacking the Siah2 gene, fail to develop BRAF-mutation carrying melanoma from the corresponding cells, completely rejecting them. This could help in boosting the anticancer effect of existing specific immune checkpoint inhibitors, such as anti-PD-1 drugs.

10 Jan 2020

Rejuvenating the BCG Vaccine

A new primate study published in the journal Nature in January 2020, reports that the almost century-old BCG vaccine against tuberculosis, may be used differently to achieve better protection against lung tuberculosis. While more work remains to be carried out before the findings can be accepted as the basis for clinical practice, they are extremely promising in the fight against this killer.

10 Jan 2020

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis.

10 Jan 2020

First patient recruited for UK-wide Parkinson's disease trial

The first patient has been recruited for a UK-wide trial into tackling one of the most disabling complications of Parkinson's disease, led by the Royal United Hospitals Bath NHS Foundation Trust and the University of Bristol.

9 Jan 2020

Clinical trial tests experimental stem cell treatment against best available drugs for MS

A clinical trial has begun testing an experimental stem cell treatment against the best available biologic therapies for severe forms of relapsing multiple sclerosis.

7 Jan 2020

AI Therapeutics reports considerable progress on LAM-001 and LAM-004 clinical trials

AI Therapeutics is a clinical-stage biopharmaceutical company that has created an artificial intelligence-driven drug development platform for matching drugs to new indications.

7 Jan 2020

New antibody-drug conjugate shows promising activity in salivary gland tumors

The antibody-drug conjugate ado-trastuzumab emtansine (T-DM1) has promising activity in HER2 amplified salivary gland tumors, according to data published in the Annals of Oncology.

7 Jan 2020

Phase II case-control trial initiated for four types of terminal cancers

The Alexandrov National Cancer Centre begins phase II case-control clinical trial of its immuno-oncology agent, Elenagen.

7 Jan 2020

Drug trial seeking treatment option for hyperphagia in patients with Prader-Willi Syndrome

One in every 15,000 children is affected by Prader-Willi syndrome (PWS), a complex, genetic endocrine condition caused by a disorder of chromosome 15. It's non-inheritable, meaning the condition isn't passed down from a family member.

3 Jan 2020

Data results of NCI-MATCH trial in tumors with DNA mismatch repair deficiencies

Final results are published from an evaluation of 42 patients treated with the immune checkpoint inhibitor nivolumab in the large multi-arm precision medicine trial, NCI-Molecular Analysis for Therapy Choice (NCI-MATCH or EAY131).

20 Dec 2019

FDA approves new drug to treat adults with advanced urothelial or bladder cancer

The U.S. Food & Drug Administration granted accelerated approval to the drug enfortumab vedotin (EV) to treat adult patients with advanced urothelial or bladder cancer.

19 Dec 2019

New standards needed for improving the design of clinical trials for MS patients

How can the perspectives of patients with multiple sclerosis (MS) be given more consideration in clinical trials? This question was investigated and corresponding recommendations were developed by a working group of the Drug Commission of the German Medical Association, the Charité University Hospital Berlin, and the Institute for Quality and Efficiency in Health Care.

17 Dec 2019

Novel drug shows efficacy against advanced ROS1 and NTRK fusion-positive NSCLC

Pooled analysis of three phase 1 and 2 clinical trials published online ahead of print in the journal Lancet Oncology show that the drug entrectinib is effective and well-tolerated against advanced ROS1 and NTRK fusion-positive non-small cell lung cancers (NSCLC).

14 Dec 2019

10-year results from clinical trial of extended letrozole therapy for women with HR+ breast cancer

In the updated results from NRG Oncology/NSABP B-42 trial through 10 years of observation, extending letrozole therapy for additional five years after five years of adjuvant endocrine therapy resulted in a statistically significant improvement in the 10-year disease-free survival (DFS) of postmenopausal women with hormone-receptor-positive breast cancer.

12 Dec 2019

Anastrozole can be preventive drug-of-choice for women with high breast cancer risk

The Queen Mary University of London professor leading an international breast cancer study says anastrozole - rather than tamoxifen - should be the preventive drug-of-choice for post-menopausal women at increased risk of developing the disease.

12 Dec 2019

Treatment combination improves survival in advanced HER2-positive breast cancer patients

Researchers from The University of Texas MD Anderson Cancer Center today reported study results showing the addition of tucatinib to capecitabine (Xeloda) and trastuzumab (Herceptin) significantly improved progression-free survival (PFS) and overall survival (OS) in patients with advanced HER2-positive breast cancer, with and without brain metastasis according to results of the HER2CLIMB clinical trial.

11 Dec 2019

UMSOM researchers to test the safety, tolerability of prototype Shigella-ETEC vaccine

Each year, millions of people contract serious diarrheal illnesses typically from contaminated food and water. Among the biggest causes of diarrheal diseases are the bacteria Shigella and enterotoxigenic Escherichia coli, and researchers at the University of Maryland School of Medicine are testing a vaccine designed to offer protection against these serious pathogens.

10 Dec 2019

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Drug Trial News

First randomized clinical trial compares targeted therapies for acute lymphoblastic leukemia

UK-wide trial aims to find treatments that can slow or reverse MND

Flash Radiotherapy could Deliver all the Radiation Needed in One Rapid Treatment

Siah2 Gene Control could Help Treat Melanomas More Effectively

Rejuvenating the BCG Vaccine

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

First patient recruited for UK-wide Parkinson's disease trial

Clinical trial tests experimental stem cell treatment against best available drugs for MS

AI Therapeutics reports considerable progress on LAM-001 and LAM-004 clinical trials

New antibody-drug conjugate shows promising activity in salivary gland tumors

Phase II case-control trial initiated for four types of terminal cancers

Drug trial seeking treatment option for hyperphagia in patients with Prader-Willi Syndrome

Data results of NCI-MATCH trial in tumors with DNA mismatch repair deficiencies

FDA approves new drug to treat adults with advanced urothelial or bladder cancer

New standards needed for improving the design of clinical trials for MS patients

Novel drug shows efficacy against advanced ROS1 and NTRK fusion-positive NSCLC

10-year results from clinical trial of extended letrozole therapy for women with HR+ breast cancer

Anastrozole can be preventive drug-of-choice for women with high breast cancer risk

Treatment combination improves survival in advanced HER2-positive breast cancer patients

UMSOM researchers to test the safety, tolerability of prototype Shigella-ETEC vaccine

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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