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Evaluating safety and efficacy of migraine preventive treatment for children, adolescents

Cephalalgia, the official journal of the International Headache Society, published the article entitled "Cinnarizine and sodium valproate as the preventive agents of pediatric migraine: A randomized double-blind placebo-controlled trial", by Man Amanat, and Mahmoud Reza Ashrafi from the Tehran University of Medical Sciences, Tehran, Iran.

10 Dec 2019

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia that has relapsed.

10 Dec 2019

Pairing chemotherapy azacitidine with enasidenib boosts complete remission in AML patients

A multi-institutional, Phase II study led by The University of Texas MD Anderson Cancer Center showed that pairing standard chemotherapy azacitidine (AZA) with a drug called enasidenib (ENA) measurably boosts complete remission in patients newly diagnosed with a specific form of acute myeloid leukemia (AML).

9 Dec 2019

Study shows safety of palbociclib for advanced breast cancer patients with unique gene alteration

Women who receive palbociclib (Ibrance) to treat their advanced breast cancer and have a gene alteration that can lead to a condition known as benign ethnic neutropenia (BEN), can safely receive the drug without major concerns of developing infections associated with neutropenia, or low white blood cell counts, say Georgetown Lombardi Comprehensive Cancer Center researchers.

9 Dec 2019

$Experimental immunotherapy can put patients with relapsed or refractory lymphoma into remission$

Experimental immunotherapy can put patients with relapsed or refractory lymphoma into remission

A new, experimental immunotherapy can put patients with B-cell non-Hodgkin lymphoma (NHL) that is resistant to or has come back after multiple other therapies, including CAR T therapy, into remission.

8 Dec 2019

Ibrutinib-based therapy provides superior clinical outcomes in majority of CLL patients

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) today announced results from an extended follow-up analysis of patients in its randomized Phase 3 clinical trial, E1912.

8 Dec 2019

Pilot clinical trial tests new treatment for type 1 diabetes

Type 1 diabetes is a chronic condition in which the body's own immune system attacks and destroys beta cells in the pancreas. Once the beta cells are destroyed, the pancreas can no longer produce insulin. Currently, there is no cure for T1D and treatment focuses on managing blood sugar levels.

6 Dec 2019

Clinical trial demonstrates safety and effectiveness of oral drug to treat NASH

Patients with nonalcoholic steatohepatitis, a chronic liver disease and a leading cause for liver transplantation in the U.S., currently lack an approved drug therapy, but this may soon change.

6 Dec 2019

Drug used to treat Parkinson’s shows potential as a dementia treatment

Drug used to treat hallucinations and delusions in Parkinson's shows promise as treatment for dementia-related psychosis (DRP).

5 Dec 2019

A major step toward preventing GvHD in patients receiving bone marrow transplants

A drug used for rheumatoid arthritis has moved a step closer to FDA approval for a desperately needed new use.

4 Dec 2019

Experimental drug better for repeat kidney cancer patients than FDA-approved equivalent

Kidney cancer patients who had already tried two or three different treatments had improved chances of preventing cancer progression with an experimental drug called tivozanib compared to an alternative approved by the U.S. Food and Drug Administration, according to a City of Hope-led study.

4 Dec 2019

Study finds it may be possible to treat endometriosis using an investigational cancer drug

Researchers have shown that painful endometriosis symptoms could be alleviated using an investigational cancer drug.

3 Dec 2019

Experimental therapies offer patients a greater chance of surviving Ebola virus disease

The investigational therapeutics mAb114 and REGN-EB3 offer patients a greater chance of surviving Ebola virus disease compared to the investigational treatment ZMapp, according to published results from a clinical trial conducted in the Democratic Republic of the Congo.

2 Dec 2019

New medicine could reduce number of infants dying from AIDS

A new, strawberry-flavored, granule-form medicine may be a solution for treating infants with AIDs.

2 Dec 2019

New medicine could reduce number of infant deaths from AIDS

A new, strawberry-flavored, granule-form medicine may be a solution for treating infants with AIDs.

2 Dec 2019

Study shows potential of hydromethylthionine treatment for Alzheimer's disease

In a paper published in today's online issue of the Journal of Alzheimer's Disease (DOI 10.3233/JAD-190772), TauRx has reported unexpected results of a pharmacokinetic analysis of the relationship between treatment dose, blood levels and pharmacological activity of the drug hydromethylthionine on the brain in over 1,000 patients with mild-to-moderate Alzheimer's disease.

27 Nov 2019

Scientists record assembly of ribosomes in real time

A team of scientists from Scripps Research and Stanford University has recorded in real time a key step in the assembly of ribosomes--the complex and evolutionarily ancient "molecular machines" that make proteins in cells and are essential for all life forms.

22 Nov 2019

Combination therapy improves survival in patients with hepatocellular carcinoma

Combination therapy with the PD-L1 inhibitor atezolizumab and the VEGF inhibitor bevacizumab significantly improves overall survival and progression-free survival in patients with unresectable hepatocellular carcinoma compared to standard of care, showed results from a phase 3 study reported at the ESMO Asia 2019 Congress.

22 Nov 2019

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

The trastuzumab biosimilar HLX02 achieved similar overall response rate to reference trastuzumab in women with human epidermal growth factor receptor 2-positive (HER2+) recurrent or previously untreated metastatic breast cancer, according to a large, randomized phase III study reported at the ESMO Asia 2019 Congress.

22 Nov 2019

BrainStorm publishes NurOwn ALS Phase 2 randomized clinical trial results in Neurology

BrainStorm Cell Therapeutics Inc., a leader in the development of innovative autologous cellular therapies for highly debilitating neurodegenerative diseases, today announced publication of "NurOwn Phase 2 Randomized Clinical Trial in ALS: Safety, Clinical and BioMarker Results," in the international, peer-reviewed journal Neurology.

20 Nov 2019

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Drug Trial News

Evaluating safety and efficacy of migraine preventive treatment for children, adolescents

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

Pairing chemotherapy azacitidine with enasidenib boosts complete remission in AML patients

Study shows safety of palbociclib for advanced breast cancer patients with unique gene alteration

Experimental immunotherapy can put patients with relapsed or refractory lymphoma into remission

Ibrutinib-based therapy provides superior clinical outcomes in majority of CLL patients

Pilot clinical trial tests new treatment for type 1 diabetes

Clinical trial demonstrates safety and effectiveness of oral drug to treat NASH

Drug used to treat Parkinson’s shows potential as a dementia treatment

A major step toward preventing GvHD in patients receiving bone marrow transplants

Experimental drug better for repeat kidney cancer patients than FDA-approved equivalent

Study finds it may be possible to treat endometriosis using an investigational cancer drug

Experimental therapies offer patients a greater chance of surviving Ebola virus disease

New medicine could reduce number of infants dying from AIDS

New medicine could reduce number of infant deaths from AIDS

Study shows potential of hydromethylthionine treatment for Alzheimer's disease

Scientists record assembly of ribosomes in real time

Combination therapy improves survival in patients with hepatocellular carcinoma

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

BrainStorm publishes NurOwn ALS Phase 2 randomized clinical trial results in Neurology

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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