Genomics

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The Achilles heel of APC-mutated colon tumors identified

In almost all cases of colon cancer, a specific gene is mutated – this offers opportunities to develop broadly effective therapeutic approaches. Research teams in Würzburg have taken this a step further.

5 Nov 2019

Researchers find genes from 'fossil' virus in human DNA to be active

Genes from a virus that was stitched into the human genome thousands of years ago are active, producing proteins in the human brain and other tissues, according to researchers at the University of Washington School of Medicine and the Laval University School of Medicine in Quebec, Canada.

5 Nov 2019

New, open-source database improves genomics research collaboration

Sharing datasets that reveal the function of genomic variants in health and disease has become easier, with the launch of a new, open-source database developed by Australian and North American researchers.

3 Nov 2019

UI scientists are developing new delivery tools for gene editing

News of advances in gene-editing technology raises the prospect of actually using this approach to treat disease in patients. But one of the hurdles that remains is how to deliver these tools to the right cells in the patients safely and efficiently.

31 Oct 2019

New signaling systems discovered in human cells

The human cell has a wide variety of receptors on its surface that many molecules and therapeutic drugs can bind to in order to activate signals inside the cell to regulate different physiological functions. GPCRs are the largest - and a very important - family of receptors on human cells.

31 Oct 2019

NTU study: Microorganisms show a precise daily rhythm in tropical air

Scientists from the Singapore Centre for Environmental Life Sciences Engineering at Nanyang Technological University, Singapore have found that the air in the tropics is teeming with a rich and diverse range of at least 725 different microorganisms.

30 Oct 2019

Scientists modify a toxic protein to create a biosensor

Researchers have shown that the pore-forming toxin (PFT), aerolysin, could be used as a biosensor in the sequencing of DNA and proteins.

30 Oct 2019

Improved Cas9 enzyme reduces chance of off-target CRISPR mutations

Genomics experts have discovered that when guide RNAs (gRNA) are designed properly, the risk of off-target mutations induced by the cas9 enzyme is very rare.

30 Oct 2019

Novel, cost-effective method successfully identifies aggressive tumors

Researchers have developed a novel, cost-effective genomic method that can identify highly heterogenous tumors that are typically aggressive in nature.

30 Oct 2019

Landmark study pinpoints the birthplace of modern humans

A landmark study led by Sydney researchers pinpoints the birthplace of modern humans in southern Africa and suggests how climate change may have driven the first migrations.

29 Oct 2019

Researchers develop new genomic analysis method for identifying Yersinia strains

The Yersinia genus covers a vast range of bacteria that are distinguished by criteria such as whether or not they are able to cause disease (their pathogenicity).

29 Oct 2019

Researchers reconstruct the evolutionary history of metabolism

By analyzing how metabolic enzymes are built and organized, researchers have reconstructed the evolutionary history of metabolism. Their study shows how metabolic networks - which drive every cellular process from protein building to DNA repair - became less random, more modular and more hierarchical over time, the researchers say.

29 Oct 2019