Genomics

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Using CRISPR-Cas9 genome editing to correct mutation responsible for sickle cell disease

Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells. Prior to adoption as a medical therapeutic, safety concerns relating to off-target effects must be minimized to mitigate risks that may arise from the unintended action of this system at sites similar, but not identical, to the desired gene target site.

From Integrated DNA Technologies 10 Aug 2018

New approach identifies genes that help microbes to survive in the human gut

Trillions of tiny microbes and bacteria live in your gut, each with their own set of genes. These gut microbes can have both beneficial and harmful effects on your health, from protecting you against inflammation to causing life-threatening infections.

10 Aug 2018

Study identifies key role of TLK1 and TLK2 enzymes in DNA replication

During cell growth, cells copy their DNA through a process called DNA replication. For this process to be accurate, the genetic and epigenetic information must be copied flawlessly.

9 Aug 2018

ETH scientists discover new cancer-specific molecular changes in tumor tissues

A research team led by Gunnar Raetsch, Professor of Biomedical Informatics at ETH Zurich, has evaluated the largest set of genetic data in cancer medicine: The Cancer Genome Atlas in the United States.

9 Aug 2018

Defects in RNA modification can cause altered smooth muscle contraction

Genetic information is stored in DNA and is passed on in a very stable manner from one cell to the next or from one generation to the next.

9 Aug 2018

Researchers provide new insight on origins and global spread of HBV

Researchers have provided new insight on the geographical origins and global spread of two classes of the hepatitis B virus (HBV), according to a study in eLife.

7 Aug 2018

Study identifies key gene to accelerate sugarcane growth

Despite international breeding efforts, advanced agronomy and effective management of pests and diseases, sugarcane yields have been static for decades owing to constraints on culm development.

6 Aug 2018

Research highlights how heritable and environmental factors can influence epigenetic variations

New research highlights the extent to which epigenetic variation is influenced by both inherited and environmental factors.

3 Aug 2018

Discovery of new epithelial lung cell type may affect cystic fibrosis therapy

Scientists have discovered a new type of cell in the human respiratory tract called the pulmonary ionocyte, and linked it to cystic fibrosis.

3 Aug 2018

UW-Madison researcher explores how female fertility is affected by development of the ovary in mice

When Joan Jorgensen was an undergraduate at the University of Wisconsin–Madison, her roommate confided that she had just one period before going through menopause in high school.

3 Aug 2018

Genome-wide association study identifies 151 genes for atrial fibrillation

Drawing on genomic data from more than one million individuals, researchers from the University of Michigan have led a large collaborative effort to discover as-yet unknown genetic risk factors for atrial fibrillation: an irregular, often rapid heart rate affecting millions of Americans and more than 30 million people worldwide.

3 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma - the second most common bone cancer in children and young adults - unleashes tumor growth.

2 Aug 2018

Researchers use DNA editing tool to reveal mechanisms behind autoimmune diseases

A group of researchers at the University of São Paulo in Brazil used a DNA editing tool called CRISPR/Cas9 to manipulate on of the genes associated to the autoaggressive T lymphocytes responsible for inducing autoimmune diseases such as autoimmune polyglandular syndrome type 1 and type 1 diabetes.

2 Aug 2018

Innovative 'EvolvR' system lets scientists shuffle genes until they get right variation

Scientists at the Innovative Genomics Institute have concocted a transformative new way to harness the power of evolution.

2 Aug 2018

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

In an article published July 17, 2018 by Nature Communications, a highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report that normal breast cells can prevent successful radiation treatment of breast cancer due to dysregulation between tumor suppressors and oncogenes.

2 Aug 2018

Breakthrough in stem cell research could lead to cure for cystic fibrosis

Researchers have successfully proved that gene therapy can be used to convert adult stem cells into functioning lung cells for the treatment of cystic fibrosis

2 Aug 2018

Researchers reveal molecular mechanisms that make people with EV prone to ß-HPVs

Keratinocyte skin cells are common targets of the beta subtype of human papilloma virus. This usually harmless infection causes skin disease in people with rare gene mutations.

2 Aug 2018

New method tags breast implants with tomato DNA to prevent counterfeiting

For years, a French company sold breast implants made of cheap industrial silicone components. Headline news when it broke in 2010, this scandal is still keeping the courts busy today.

2 Aug 2018

Computer simulations can accurately predict transmission of HIV

In a recently published study in the journal Nature Microbiology, researchers at Los Alamos National Laboratory show that computer simulations can accurately predict the transmission of HIV across populations, which could aid in preventing the disease.

1 Aug 2018

Genomics

Using CRISPR-Cas9 genome editing to correct mutation responsible for sickle cell disease

New approach identifies genes that help microbes to survive in the human gut

Study identifies key role of TLK1 and TLK2 enzymes in DNA replication

ETH scientists discover new cancer-specific molecular changes in tumor tissues

Defects in RNA modification can cause altered smooth muscle contraction

Researchers provide new insight on origins and global spread of HBV

Study identifies key gene to accelerate sugarcane growth

Research highlights how heritable and environmental factors can influence epigenetic variations

Discovery of new epithelial lung cell type may affect cystic fibrosis therapy

UW-Madison researcher explores how female fertility is affected by development of the ovary in mice

Genome-wide association study identifies 151 genes for atrial fibrillation

Scientists map regulatory landscape of mouse genome at single-cell resolution

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

Researchers use DNA editing tool to reveal mechanisms behind autoimmune diseases

Innovative 'EvolvR' system lets scientists shuffle genes until they get right variation

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

Breakthrough in stem cell research could lead to cure for cystic fibrosis

Researchers reveal molecular mechanisms that make people with EV prone to ß-HPVs

New method tags breast implants with tomato DNA to prevent counterfeiting

Computer simulations can accurately predict transmission of HIV

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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