Genomics

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TGen opens tissue donation portal to advance DIPG research

A tissue donation portal opened today at the Translational Genomics Research Institute (TGen), which will advance research towards new treatments for an aggressive brain cancer that mostly strikes young children.

19 Jul 2018

Study uncovers new protein complex that shields broken DNA ends

Scientists have made a major discovery about how cells repair broken strands of DNA that could have huge implications for the treatment of cancer.

19 Jul 2018

Study finds link between DNA methylation and non-alcoholic fatty liver disease

DNA methylation is a molecular process that helps enable our bodies to repair themselves, fight infection, get rid of environmental toxins, and even to think. But sometimes this process goes awry.

19 Jul 2018

Study identifies RNA molecules that regulate male hormones in prostate cancer

In most cases of prostate cancer, tumor cell growth is stimulated by the action of male hormones, or androgens, such as testosterone and dihydrotestosterone.

19 Jul 2018

Researchers identify subtypes of retinal ganglion cells using single-cell RNA sequencing

Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center and The Jackson Laboratory have identified 40 subtypes of retinal ganglion cells along with the genetic markers and transcription factors that differentiate them.

19 Jul 2018

Deleting single gene in gut bacteria affects metabolism, reduces weight gain in mice

Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice, according to a study in the journal eLife.

18 Jul 2018

Researchers identify key protein involved in irregular brain cell activity

In a new study in mice, researchers have identified a key protein involved in the irregular brain cell activity seen in autism spectrum disorders and epilepsy. The protein, p53, is well-known in cancer biology as a tumor suppressor.

17 Jul 2018

Large international study finds new risk genes for hay fever

In a large international study involving almost 900,000 participants, researchers from the University of Copenhagen and COPSAC have found new risk genes for hay fever. It is the largest genetic study so far on this type of allergy, which affects millions of people around the world.

17 Jul 2018

FAU and partners receive NIH research grant to shed light on sleep loss and metabolic disorders

A neuroscientist from Florida Atlantic University's Jupiter Life Science Initiative and collaborators from the University of Minnesota and Stowers Institute for Medical Research recently a received a four-year, $1.68 million R01 research grant from the National Institutes of Health's National Institute of General Medical Sciences for a project titled, "Understanding Complex Trait Architecture through Population Genomics."

17 Jul 2018

Study reveals new risk genes for allergic rhinitis

An international team of scientists led by Helmholtz Zentrum München and University of Copenhagen has presented the largest study so far on allergic rhinitis in the journal 'Nature Genetics'.

17 Jul 2018

Researchers develop machine learning method to predict unknown gene functions of microbes

An international team led by computational biologist Fran Supek at IRB Barcelona develop a machine learning method to predict unknown gene functions of microbes.

17 Jul 2018

Study identifies new genes linked to heart function and development

A new study from an international research team, led by Dr Yalda Jamshidi at St George's, University of London, has identified new genes associated with heart function and development.

17 Jul 2018

Scientists identify hidden signals in RNAs that control protein synthesis

Scientists have long known that RNA encodes instructions to make proteins. The building blocks that comprise RNA-;A, U, C, and Gs-;form a blueprint for the protein-making machinery in cells. To make proteins, the machinery latches on RNA at one end and then scans along the RNA until it reaches an AUG string, which is the signal to start translating the genetic code into a protein.

17 Jul 2018

New machine learning framework predicts effects of genetic mutations in ‘dark matter’ regions

A new machine learning framework, dubbed ExPecto, can predict the effects of genetic mutations in the so-called "dark matter" regions of the human genome.

17 Jul 2018

CRISPR/Cas9 gene editing can cause greater genetic damage than previously thought

Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells.

16 Jul 2018

Researchers solve mystery of final blood group system

Ever since the blood type was discovered in 1962, no one has been able to explain why some people become Xga positive while others are Xga negative.

16 Jul 2018

Researchers seek to understand role of APOE mutation in Alzheimer's disease

If you had your genome sequenced and the report says you have the APOEε4 mutation, it does not mean you are definitely going to get Alzheimer's disease.

16 Jul 2018

Research sheds on how new species may arise from rapid mitochondrial evolution

Genetic research at Oregon State University has shed new light on how isolated populations of the same species evolve toward reproductive incompatibility and thus become separate species.

13 Jul 2018

Researchers reveal massive genome havoc in breast cancer

In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations -- larger-scale rearrangements of DNA that can encompass large chunks of chromosomes -- disturb carefully balanced mechanisms that have evolved to regulate cell growth.

13 Jul 2018

Whole genome sequencing shows tight clustering between bacterial isolates in returning travelers

Thirteen patients with OXA-48-producing Klebsiella pneumoniae ST392 have been reported by Sweden and Norway between January and April 2018 - all returning travellers with prior hospital admission in Gran Canaria, Spain.

13 Jul 2018