Genomics

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New computational strategy used to identify genes associated with childhood cancer

Using a new computational strategy, researchers at UT Southwestern Medical Center have identified 29 genetic changes that can contribute to rhabdomyosarcoma, an aggressive childhood cancer.

3 Jul 2018

Researchers develop switch that can control genome editing

Researchers have developed a biological switch that reliably triggers protein expression and enables the control of genome editing tools.

3 Jul 2018

New biomarker paves way for personalized bladder cancer treatments

Researchers have identified a potential new target for the treatment of a particularly aggressive form of bladder cancer, in the form of microRNA.

2 Jul 2018

Simple DNA test can predict risk of bad side effects to thiopurine drugs

Screening a tiny section of DNA could help East Asian patients avoid severe reactions to some medications.

2 Jul 2018

Researchers discover gene that plays role in regulating body's immune response to infection

Australia's national science agency CSIRO has identified a new gene that plays a critical role in regulating the body's immune response to infection and disease.

2 Jul 2018

Timing may be key to evading destruction for bacteria facing antibiotics

For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.

30 Jun 2018

Individuals may react differently to environmental chemicals based upon genetic profile

Why do individuals respond differently to the same environment? Researchers from North Carolina State University and Oregon State University have pinpointed a genetic difference in zebrafish tied to differing responses to the same environmental chemical.

30 Jun 2018

Study: Administration of endocrine disruptor causes epigenetic changes in pregnant sow's DNA

The public debate on endocrine disrupting chemicals- exogenous substances that have the same or similar effects as endogenous hormones - has been going on for some time.

30 Jun 2018

Lamin proteins organize a cell's genetic material from the sidelines

A tremendous amount of genetic material must be packed into the nucleus of every cell--a tiny compartment.

29 Jun 2018

Only one of 21 genes in BrS genetic test found to be associated with Brugada Syndrome

Clinical laboratories often rely on medical articles and public information on gene disease associations in determining the genes to include on genetic testing panels for specific conditions or the specific results to return to patients.

29 Jun 2018

Genes associated with autism interact to modulate variable symptoms of disease

Genes located in a large chromosomal aberration associated with autism interact with each other to modulate the variable symptoms of the disease, according to new research.

29 Jun 2018

Human leukemia virus increases disease risk by changing the way DNA loops inside our cells

A human virus that causes a rare form of leukemia increases the risk of disease by changing the way DNA loops inside our cells.

29 Jun 2018

Researchers find link between mutations in TRAF7 gene and multisystem disorder

A group of seven patients presenting with a similar disorder of unknown origin now know of a possible genetic root of their condition.

28 Jun 2018

DNA methylation predicts survival outcome in patients with glioma

A new study has shown that survival rates among patients with glioma double if the tumor carries a methylated MGMT gene.

28 Jun 2018

Rethinking current method paves way for new, personalized cancer diagnostics

All diseases have a genetic component. Advances in understanding the genetic mechanisms behind these disease enables the development of early diagnostic tests, new treatments, or interventions to prevent disease onset or minimize disease severity.

28 Jun 2018

Texas A&M research paves way for more DNA studies

Dr. Wonmuk Hwang, associate professor in the Department of Biomedical Engineering at Texas A&M University, is researching the mechanics of DNA, the blueprint of the human body.

27 Jun 2018

UPMC and Pitt announce launch of advanced genome sequencing center

UPMC and the University of Pittsburgh today announced the launch of an advanced genome sequencing center to support clinical diagnostics and research initiatives in precision medicine and immunotherapy.

27 Jun 2018

Error in most widely used method in epigenetics can cause misleading results

An error in one of the most widely used methods in epigenetics, DIP-seq, can cause misleading results, researchers at Linköping University, Sweden, have shown. This may have major significance in the research field, where "big data" and advanced methods of DNA analysis are used to study vast amounts of epigenetic data.

26 Jun 2018

Special collection of papers highlights research on craniofacial genetics

Our faces can reveal a lot about us, and now scientists are revealing a lot about faces. PLOS Genetics announces a special collection of papers to highlight recent advances in our understanding of how faces form, curated by Seth Weinberg of the University of Pittsburgh, and colleagues.

26 Jun 2018