Genomics

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New CRISPR approach is a leap forward in developing personalized treatment for cancer

For the first time, scientists have used CRISPR technology to insert genes that allow immune cells to focus their attack on cancer cells, potentially leaving normal cells unharmed and increasing the effectiveness of immunotherapy.

10 Nov 2022

Proteomics approach helps identify protein signatures that can improve detection of prediabetes

Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes.

10 Nov 2022

High-quality reference genome assembly of the Nile rat facilitates diabetes research

Model organisms are essential for biomedical research and have enabled many important scientific discoveries. The ability to sequence the genomes of these models is a powerful tool to study the genetic factors that impact human health.

9 Nov 2022

Researchers unravel neurobiological mechanisms impacted by early life adversity

Using cutting edge molecular techniques in rodent models, researchers are dissecting the neurobiological mechanisms impacted by early life adversity.

9 Nov 2022

Scientists determine 5,072 essential human genes

In a recent study published in the journal Cell, researchers examined the phenotypic landscape of multiple elusive essential human genes to create a detailed genotype-phenotype resource outlining the phenotypic consequences of disrupting fundamental cellular processes.

8 Nov 2022

Protein complex may present strong therapeutic target for lethal breast cancer

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that a protein complex that governs gene expression (called CoREST) sometimes gets rewired during breast cancer to help estrogen receptor positive (ER+) tumors resist endocrine therapies and become more aggressive.

8 Nov 2022

Genetic variant associated with slimness estimated to be present in almost 60% of the Europeans

How much do genes influence our body weight? For the general population this influence is around 20%, according to studies that in recent years have analyzed the complete genome of tens of thousands of people.

8 Nov 2022

Study shows the added value of genetic information in measuring inherited disease risk

A new study from the University of Helsinki demonstrates the added value of genetic information in measuring inherited disease risk, alongside the widely used assessment of family history.

8 Nov 2022

Researchers unravel genetic changes in a region that controls the activity of the genome

Scientists have discovered the cause of a rare condition within a part of the genome that has been largely unexplored in medical genetics. A team at the University of Exeter has found genetic changes in a region that controls the activity of the genome, turning on or off genes, and in doing so they have found a key that could unlock other causes of rare conditions.

8 Nov 2022

Chromosomal microarray analysis could help identify the cause of SIDS or SUDC in older children

A genetic test known as chromosomal microarray analysis (CMA) could help identify the cause of sudden infant death syndrome (SIDS) or its counterpart in older children, known as sudden unexplained death in childhood (SUDC), finds a study led by Boston Children's Hospital.

7 Nov 2022

DNA barcoding shows how cancer cells evade the immune system's defenses

Some cancer cells can deploy parallel mechanisms to evade the immune system's defences as well as resist immunotherapy treatment, according to a new study from the Garvan Institute of Medical Research.

7 Nov 2022

Personalized whole genome sequencing approach could double the diagnostic rates of rare diseases

Tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases, finds a new study led by UCL researchers.

7 Nov 2022

UAB researchers report lack of predictability for fecal microbial transplants without prior antibiotic therapy

A fecal microbial transplant -; giving a recipient fecal matter from a donor to change the recipient's gut microbial community in the colon -; has been a successful last resort therapy for people with recurrent Clostridium difficile infection after multiple rounds of suppressive antibiotics have eliminated the recipient microbial community.

4 Nov 2022

New evaluation data shows the clinical utility of SOPHiA DDM Dx HRD Solution

SOPHiA GENETICS, a cloud-native software company in the healthcare space, debuted new data at the European Society of Gynaecological Oncology (ESGO) Congress as part of a poster (#PA-065) presented by Prof. Alexandre Harlé of the Institut de Cancérologie de Lorraine, France.

3 Nov 2022

Parental discord linked to children's genetic risk for alcohol problems

Parents can transmit a genetic risk for alcohol problems to their children not only directly, but also indirectly via genetically influenced aspects of the home environment, such as marital discord or divorce, according to a Rutgers researcher.

3 Nov 2022

Whole-genome sequencing is a more comprehensive prenatal test l BGI Perspectives

BGI-Research and the Maternal and Child Health Hospital of Hubei Province (MCHH) published whole-genome sequencing research results in npj Genomic Medicine.

From BGI Genomics 3 Nov 2022

Research reveals how whole-genome sequencing may enhance detection of fetal CNS anomalies

BGI-Research and the Maternal and Child Health Hospital of Hubei Province (MCHH) published whole-genome sequencing research results in npj Genomic Medicine.

3 Nov 2022

New control system could be used to finely tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

1 Nov 2022

Study provides more nuanced insights into RNA modifications by A-to-I editing during brain development

Mount Sinai researchers have cataloged thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.

1 Nov 2022

Ancient genomes shed light on previously unknown aspect of human evolution

The use of ancient DNA, including samples of human remains around 45,000 years old, has shed light on a previously unknown aspect of human evolution.

31 Oct 2022

Genomics

New CRISPR approach is a leap forward in developing personalized treatment for cancer

Proteomics approach helps identify protein signatures that can improve detection of prediabetes

High-quality reference genome assembly of the Nile rat facilitates diabetes research

Researchers unravel neurobiological mechanisms impacted by early life adversity

Scientists determine 5,072 essential human genes

Protein complex may present strong therapeutic target for lethal breast cancer

Genetic variant associated with slimness estimated to be present in almost 60% of the Europeans

Study shows the added value of genetic information in measuring inherited disease risk

Researchers unravel genetic changes in a region that controls the activity of the genome

Chromosomal microarray analysis could help identify the cause of SIDS or SUDC in older children

DNA barcoding shows how cancer cells evade the immune system's defenses

Personalized whole genome sequencing approach could double the diagnostic rates of rare diseases

UAB researchers report lack of predictability for fecal microbial transplants without prior antibiotic therapy

New evaluation data shows the clinical utility of SOPHiA DDM Dx HRD Solution

Parental discord linked to children's genetic risk for alcohol problems

Whole-genome sequencing is a more comprehensive prenatal test l BGI Perspectives

Research reveals how whole-genome sequencing may enhance detection of fetal CNS anomalies

New control system could be used to finely tune the production of useful proteins

Study provides more nuanced insights into RNA modifications by A-to-I editing during brain development

Ancient genomes shed light on previously unknown aspect of human evolution

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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