Genomics

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Neutral or awkward behavior of mothers with infants linked to an epigenetic change in children

Adding evidence to the importance of early development, a new study links neutral maternal behavior toward infants with an epigenetic change in children related to stress response.

2 Mar 2023

Study results provide strong evidence for association of genetic markers to long COVID mappable to fatigue

Researchers analyzed polygenic risk scores in whole genome sequences obtained from blood samples of long COVID patients to determine genomic predictors of long COVID.

2 Mar 2023

Gene variant found in individuals of African ancestry dramatically boosts Alzheimer's risk

Stanford Medicine scientists and their colleagues have discovered that a gene variant found almost exclusively in the genomes of individuals of African ancestry dramatically boosts Alzheimer's risk. About 4% of African Americans carry this variant.

1 Mar 2023

Key 'traffic light' mechanism controlling genetic activity within cells revealed

A major new study in the journal Nature reveals a 'traffic light' mechanism controlling genetic activity within cells – a system which could potentially be targeted by cancer drugs already in development.

1 Mar 2023

Largest genomic study focuses on the prognosis of metastatic pheochromocytomas

Pheochromocytoma is a rare tumor, with an incidence of three to eight cases per million population per year.

28 Feb 2023

Brain over-activation could be causing seizures and social deficits in genetic subtype of autism

Northwestern Medicine scientists have identified the cause of a genetic subtype of autism and schizophrenia that results in social deficits and seizures in mice and humans.

28 Feb 2023

Mutation in a single non-coding gene found to be the source of multisystemic smooth muscle dysfunction syndrome

A team of investigators from Massachusetts General Hospital, a founding member of Mass General Brigham and Mass General for Children has identified - for the first time - the mutation in a single non-coding gene of a young patient responsible for the extremely rare disease known as multisystemic smooth muscle dysfunction syndrome, which causes profound cerebrovascular, gastrointestinal and urologic impairment.

28 Feb 2023

Study finds unique epigenetic biosignature in individuals with post-COVID syndrome

A reprogramming of which genes are active, and which are not, is visible in post-COVID sufferers. This is shown in a study from Linköping University, Sweden, on a small group of individuals.

28 Feb 2023

Study reveals new mechanism in the arms race between bacteria and viruses

UT Southwestern biochemist Zhijian "James" Chen, Ph.D., famously identified the cGAS enzyme pathway that alerts the human immune system to disease-causing invaders like viruses.

28 Feb 2023

Tecan and Oxford Nanopore build alliance to create automated, seamless and fully compatible nanopore sequencing library preparation for any-length fragments of native DNA/RNA

The Tecan Group and Oxford Nanopore Technologies plc (Oxford Nanopore) today announce their collaboration to drive easier high-throughput nanopore library preparation in an automated, hands-free fashion.

From Tecan 27 Feb 2023

Introducing Tecan’s MagicPrep™ NGS – the walkaway solution for your NGS library prep needs

Tecan has launched the MagicPrep NGS, an automated benchtop library preparation system that transforms time-consuming and error-prone procedures into a simple, robust experience.

From Tecan 27 Feb 2023

New insights into how amino acids shaped the genetic code of ancient microorganisms

By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today - including plants, animals, and humans.

27 Feb 2023

The relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality

Researchers assessed the association between deoxyribonucleic acid methylation (DNAm)-based clocks or aging measures and demographic and serological parameters in estimating health-associated outcomes, including deaths.

24 Feb 2023

Predicting the likelihood of kidney cancer recurrence by looking at DNA mutations

A decade-long international study into kidney cancer has shown that doctors can predict the likelihood of a patient's disease returning by looking at DNA mutations in their tumors.

24 Feb 2023

A network of interacting proteins created to aid drug discovery

Scientists at Open Targets, EMBL's European Bioinformatics Institute, and GSK are revealing the shared basis of diseases using a map of interacting human proteins.

24 Feb 2023

Cryo-EM imaging reveals molecular machine’s secret weapon

RNAs are having a moment. The foundation of COVID-19 vaccines, they've made their way from biochemistry textbooks into popular magazines and everyday discussions. Entire companies have launched dedicated to RNA research.

24 Feb 2023

DNA sequencing may help predict a patient’s risk of kidney cancer recurrence

Studying the mutations in kidney cancer after surgery could help to better predict the risk of the disease coming back, according to the latest results of a decade-long international study.

23 Feb 2023

Study may elucidate metformin's potential role in longevity through DNA methylation

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 3, entitled, "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity."

22 Feb 2023

Scientists identify mechanisms underlying autoimmunity in Down syndrome

Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome.

22 Feb 2023

New model contributes to the understanding of huge variety of genome sizes in nature

A new model developed at Tel Aviv University offers a possible solution to the scientific question of why neutral sequences, sometimes referred to as "junk DNA", are not eliminated from the genome of living creatures in nature and continue to exist within it even millions of years later.

22 Feb 2023

Genomics

Neutral or awkward behavior of mothers with infants linked to an epigenetic change in children

Study results provide strong evidence for association of genetic markers to long COVID mappable to fatigue

Gene variant found in individuals of African ancestry dramatically boosts Alzheimer's risk

Key 'traffic light' mechanism controlling genetic activity within cells revealed

Largest genomic study focuses on the prognosis of metastatic pheochromocytomas

Brain over-activation could be causing seizures and social deficits in genetic subtype of autism

Mutation in a single non-coding gene found to be the source of multisystemic smooth muscle dysfunction syndrome

Study finds unique epigenetic biosignature in individuals with post-COVID syndrome

Study reveals new mechanism in the arms race between bacteria and viruses

Tecan and Oxford Nanopore build alliance to create automated, seamless and fully compatible nanopore sequencing library preparation for any-length fragments of native DNA/RNA

Introducing Tecan’s MagicPrep™ NGS – the walkaway solution for your NGS library prep needs

New insights into how amino acids shaped the genetic code of ancient microorganisms

The relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality

Predicting the likelihood of kidney cancer recurrence by looking at DNA mutations

A network of interacting proteins created to aid drug discovery

Cryo-EM imaging reveals molecular machine’s secret weapon

DNA sequencing may help predict a patient’s risk of kidney cancer recurrence

Study may elucidate metformin's potential role in longevity through DNA methylation

Scientists identify mechanisms underlying autoimmunity in Down syndrome

New model contributes to the understanding of huge variety of genome sizes in nature

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