Genomics

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Using unsupervised machine learning algorithms to classify osteosarcoma

A new editorial paper was published in Oncotarget's Volume 14 on February 11, 2023, entitled, "Unlocking the potential of molecular-driven stratification for osteosarcoma treatment and prognosis."

20 Mar 2023

Hox genes control stem cells involved in forming and repairing bone

Genes long known to control the formation of bones before birth also control bone healing later in life, a new study found.

20 Mar 2023

Decreased viral infection severity in females may be due to extra copy of X chromosome-linked gene

It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery – until possibly now.

17 Mar 2023

CRISPR-based genome editing restores the vision of mice with retinitis pigmentosa

Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans.

17 Mar 2023

Genomic analysis of Ashaninka individuals reveals an unexpected amount of underlying diversity

The Ashaninka are the most numerous Indigenous people living in the rainforests of Peru and Brazil where they inhabit a crucial area between the Andes and sources of the Amazon River. And yet, despite the size of the population and their importance in the past and present, their genetic history has remained understudied.

17 Mar 2023

Computational analysis of large genetic datasets reveals rare disease etiologies

Using a new computational approach they developed to analyze large genetic datasets from rare disease cohorts, researchers at the Icahn School of Medicine at Mount Sinai and colleagues have discovered previously unknown genetic causes of three rare conditions: primary lymphedema (characterized by tissue swelling), thoracic aortic aneurysm disease, and congenital deafness.

17 Mar 2023

Bacteria require phase separation to thrive in the mammalian gut

The common commensal gut bacterium Bacteroides thetaiotaomicron uses phase separation of the transcription termination factor Rho to colonize and thrive in the mammalian gut, according to a new study in mice.

17 Mar 2023

Automata LINQ; Unlocking open, integrated lab automation

In this interview, we speak to Mostafa ElSayed, CEO of Automata, about their new, accessible, lab automation platform Automata Labs and its benefits for scientific research.

From Automata 16 Mar 2023

Scientists develop genetically defined mouse models for multiple myeloma subtypes

A team of scientists led by Martin Janz and Klaus Rajewsky at the Max Delbrück Center has successfully generated genetically defined mouse models for two subtypes of multiple myeloma.

16 Mar 2023

Scientists discover mechanism used by cancer cells to repair DNA damage induced by radiotherapy

A team of scientists led by Dr. Kei-ichi TAKATA from the Center for Genomic Integrity within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover from next-generation cancer radiation therapy.

16 Mar 2023

Study provides strong support for AAV.NT-3 gene therapy in the management of sarcopenia

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "AAV1.NT-3 gene therapy prevents age-related sarcopenia."

16 Mar 2023

Researchers uncover new clue as to how "whole genome doubling" drives cancer

A single cell contains 2-3 meters of DNA, meaning that the only way to store it is to package it into tight coils.

15 Mar 2023

‘Glow-in-the-dark’ proteins could make disease diagnosis quicker and easier

Despite recent advancements, many highly sensitive diagnostic tests for viral diseases still require complicated techniques to prepare a sample or interpret a result, making them impractical for point-of-care settings or areas with few resources.

15 Mar 2023

Researchers design a virus-resistant, more useful E. coli bacteria

In a step forward for genetic engineering and synthetic biology, researchers have modified a strain of Escherichia coli bacteria to be immune to natural viral infections while also minimizing the potential for the bacteria or their modified genes to escape into the wild.

15 Mar 2023

Genomics

Using unsupervised machine learning algorithms to classify osteosarcoma

Hox genes control stem cells involved in forming and repairing bone

Decreased viral infection severity in females may be due to extra copy of X chromosome-linked gene

CRISPR-based genome editing restores the vision of mice with retinitis pigmentosa

Genomic analysis of Ashaninka individuals reveals an unexpected amount of underlying diversity

Computational analysis of large genetic datasets reveals rare disease etiologies

Bacteria require phase separation to thrive in the mammalian gut

Automata LINQ; Unlocking open, integrated lab automation

Scientists develop genetically defined mouse models for multiple myeloma subtypes

Scientists discover mechanism used by cancer cells to repair DNA damage induced by radiotherapy

Study provides strong support for AAV.NT-3 gene therapy in the management of sarcopenia

Researchers uncover new clue as to how "whole genome doubling" drives cancer

‘Glow-in-the-dark’ proteins could make disease diagnosis quicker and easier

Researchers design a virus-resistant, more useful E. coli bacteria

A convergent coexpression approach identifies novel genes associated with autism

Study identifies link between oral and gut microbiomes and depression

New genetic animal model may inform potential therapeutic options for Down syndrome

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Hyperinflammation triggers long COVID headaches

Study reveals the shared genetic basis for endometriosis and other pain conditions

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